4-Benzothiazolol

Product Name: 4-Benzothiazolol
CAS No.: 7405-23-4
Chemical Name: 4-Benzothiazolol
Synonyms: NSC 403244;4-Benzothiazolol;Benzothiazol-4-ol;benzo[d]thiazol-4-ol;1,3-benzothiazol-4-ol;4-hydroxy-benzothiazol;4-hydroxybenzothiazole;4-Benzothiazolol(6CI,8CI,9CI);4-Benzothiazolol(saMeasBTA-4-0651)
CBNumber: CB51040815
Molecular Formula: C7H5NOS
Formula Weight: 151.19
MOL File: 7405-23-4.mol

More

Less

4-Benzothiazolol Property

Melting point:: 143℃
Boiling point:: 312℃
Density: 1.444
Flash point:: 142℃
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 7.71±0.40(Predicted)
color: Light green to green
InChI: InChI=1S/C7H5NOS/c9-5-2-1-3-6-7(5)8-4-10-6/h1-4,9H
InChIKey: NZFKDDMHHUEVPI-UHFFFAOYSA-N
SMILES: S1C2=CC=CC(O)=C2N=C1

More

Less

Safety

HS Code: 2934208090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B410608
Product name: Benzo[d]thiazol-4-ol
Packaging: 100mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B410608
Product name: Benzo[d]thiazol-4-ol
Packaging: 500mg
Price: $220
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140775
Product name: Benzo[d]thiazol-4-ol
Packaging: 500mg
Price: $260
Updated: 2021/12/16

Matrix Scientific

Product number: 119028
Product name: Benzo[d]thiazol-4-ol
Purity: 95+%
Packaging: 250mg
Price: $324
Updated: 2021/12/16

AK Scientific

Product number: Z5086
Product name: Benzo[d]thiazol-4-ol
Packaging: 5g
Price: $398
Updated: 2021/12/16

More

Less

4-Benzothiazolol Chemical Properties,Usage,Production

Uses

Benzo[d]thiazol-4-ol is a constituent of pheomelanin; a polymeric skin-?centered pigment which acts as a natural photoprotector against harmful solar-?UV radiation.

Synthesis

3048-46-2

7405-23-4

General procedure for the synthesis of 4-hydroxybenzothiazole from 4-methoxybenzothiazole: Boron bromide (3.09 mL, 1M DCM solution, 3.09 mmol) was slowly added dropwise to a stirring solution of 4-methoxybenzothiazole (510 mg, 3.09 mmol) in anhydrous dichloromethane (30 mL) at 0 °C. The reaction mixture was gradually warmed to 40 °C and stirred continuously overnight. Upon completion of the reaction, the solution was concentrated under vacuum and subsequently diluted with water and 2N hydrochloric acid. The aqueous phase was neutralized to pH 7 with sodium bicarbonate and then extracted with ethyl acetate (3 x 100 mL). The organic extracts were combined, dried with magnesium sulfate, and the solvent was removed under vacuum. The resulting oil was purified by fast chromatography on a silica gel column with the eluent ratio tapered from hexane:ethyl acetate [4:1] to hexane:ethyl acetate [7:3], resulting in 4-hydroxybenzothiazole as a brown solid (730 mg, 80% yield). The NMR hydrogen spectrum (300 MHz, CDCl3) data were as follows: δ 7.59 (1H, s, hydrogen on the thiazole ring), 7.46 (1H, dd, aromatic hydrogen), 7.36 (1H, t, aromatic hydrogen), 7.02 (1H, dd, aromatic hydrogen).

References

[1] Patent: WO2004/43903, 2004, A1. Location in patent: Page 68 - 69
[2] Patent: WO2004/43904, 2004, A1. Location in patent: Page 64 - 65
[3] Patent: WO2004/43931, 2004, A1. Location in patent: Page 42-43
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 21, p. 6199 - 6202
[5] Helvetica Chimica Acta, 1938, vol. 21, p. 709

4-Benzothiazolol Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-Benzothiazolol Suppliers

China 86 Europe 1 Germany 1 India 3 United Kingdom 2 United States 8 Global 101

CHANGZHOU HARVECHEM LTD

Tel: 0519-88721112
Fax: 0519-88721112
Email: supporting@harvechem.com
Country: China
ProdList: 81
Advantage: 58

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Shanghai yirong biology science and technology co., ltd

Tel: 18049974220
Fax: +86 (21) 51062076
Email: 3060526242@qq.com
Country: China
ProdList: 995
Advantage: 60

Shanghai Synthfine Chemical Co.,Ltd

Tel: 15921303235
Fax: QQ489466966
Email: sales@synthfine.com
Country: China
ProdList: 1041
Advantage: 58

Chiba Pharmaceutical Science and technology Co, Ltd.

Tel: 0531-81313138 13066006660
Fax: QQ: 3366077777
Email: chibapharm@foxmail.com
Country: China
ProdList: 3991
Advantage: 55

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Shanghai ChriChem Co., Ltd.

Tel: 021-54880687
Fax: 021-54880687
Country: China
ProdList: 511
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

More

Less

View Lastest Price from 4-Benzothiazolol manufacturers

Career Henan Chemical Co

Product: 4-Benzothiazolol 7405-23-4
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

7405-23-4, 4-BenzothiazololRelated Search:

4-Methoxy-2-aminobenzothiazole 4-Benzothiazolol,2-amino-(6CI,7CI,9CI) 6-Benzothiazolol,2-methyl-(6CI,7CI,9CI) 6-Benzothiazolol(7CI,8CI,9CI) 2-AMINO-6-BENZOTHIAZOLOL HCL,2-AMINO-6-BENZOTHIAZOLOL HYDROCHLORIDE 5-Benzothiazolol,2-methyl-(6CI,9CI) 4-acetoxy-2-(4-methylphenyl)benzothiazole Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI) 4-METHOXY-6-NITRO-BENZOTHIAZOL-2-YLAMINE 2-AMINO-6-CHLORO-4,7-DIMETHOXYBENZOTHIAZOLE 4-METHOXY-BENZOTHIAZOLE-2,6-DIAMINE 2-Benzothiazolamine,4-ethoxy-(9CI) 2(3H)-Benzothiazolone,4-methoxy-,hydrazone(9CI) Benzothiazole, 4-methoxy-2-methyl- (7CI,8CI,9CI) 2-AMINO-6-NITRO-BENZOTHIAZOL-4-OL 6-Benzothiazolol,2-(methylthio)-(9CI) 4-Benzothiazolol,2,6-diamino-(9CI) 4-Benzothiazolol,2-amino-6-nitro-(9CI)

4-Benzothiazolol

Benzothiazol-4-ol

4-Benzothiazolol(6CI,8CI,9CI)

4-hydroxybenzothiazole

benzo[d]thiazol-4-ol

4-Benzothiazolol(saMeasBTA-4-0651)

1,3-benzothiazol-4-ol

4-hydroxy-benzothiazol

NSC 403244

7405-23-4

BENZOTHIAZOLE