(R)-(-)-1-Methyl-3-pyrrolidinol

Product Name: (R)-(-)-1-Methyl-3-pyrrolidinol
CAS No.: 104641-60-3
Chemical Name: (R)-(-)-1-Methyl-3-pyrrolidinol
Synonyms: (R)-1-METHYLPYRROLIDIN-3-OL;(R)-1-METHYL-3-PYRROLIDINOL;UNII:CGW2AL7PQ7;Glycopyrrolate Impurity 9;Glycopyrrolate Impurity 22;(R)-N-Methyl-3-pyrrolidinol;(3R)-1-Methylpyrrolidin-3-ol;(S)-3-Hydroxy-1-methylpyr...;(3R)-1-Methyl-3-pyrrolidinol;-(-)-1-Methyl-3-pyrrolidinol
CBNumber: CB5104299
Molecular Formula: C5H11NO
Formula Weight: 101.15
MOL File: 104641-60-3.mol

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(R)-(-)-1-Methyl-3-pyrrolidinol Property

Boiling point:: 50-52 °C1 mm Hg(lit.)
alpha: -7 º (c=1%, chloroform)
Density: 0.921 g/mL at 25 °C(lit.)
refractive index: n20/D 1.4640(lit.)
Flash point:: 159 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid
pka: 14.95±0.20(Predicted)
color: Colorless to yellow to brown
optical activity: [α]20/D -7°, c = 1% in chloroform
Sensitive: Air Sensitive & Hygroscopic
BRN: 4349393
InChIKey: FLVFPAIGVBQGET-RXMQYKEDSA-N
CAS DataBase Reference: 104641-60-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: NA 1993 / PGIII
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 647241
Product name: (R)-(?)-1-Methyl-3-pyrrolidinol
Purity: 97%
Packaging: 1g
Price: $134
Updated: 2023/06/20

TCI Chemical

Product number: M1937
Product name: (R)-1-Methyl-3-pyrrolidinol
Purity: >98.0%(GC)
Packaging: 1g
Price: $92
Updated: 2025/07/31

TCI Chemical

Product number: M1937
Product name: (R)-1-Methyl-3-pyrrolidinol
Purity: >98.0%(GC)
Packaging: 5g
Price: $315
Updated: 2025/07/31

TRC

Product number: M329030
Product name: (R)-1-Methyl-3-pyrrolidinol
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Chem-Impex

Product number: 41538
Product name: (R)-(-)-1-Methyl-3-pyrrolidinol,98%(GC)
Purity: 98%(GC)
Packaging: 1G
Price: $128.8
Updated: 2021/12/16

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(R)-(-)-1-Methyl-3-pyrrolidinol Chemical Properties,Usage,Production

Chemical Properties

Brown liquid

Uses

(R)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used for asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.

Synthesis

50-00-0

40499-83-0

104641-60-3

In a 100 mL round bottom flask, 2 g of (R)-3-hydroxypyrrolidine, 25 mL of tetrahydrofuran (THF), 0.49 g of paraformaldehyde, and 1.5 g of 90% formic acid were added sequentially. The reaction mixture was stirred under reflux conditions for 5 h (until all solids were completely dissolved), after which the reaction system was cooled to 0 °C and the pH was adjusted to about 10 by slow addition of 10 mL of 10 N sodium hydroxide solution. the organic phase was separated and dried over anhydrous magnesium sulfate. After filtration to remove the desiccant, the solvent (THF) was removed by distillation under reduced pressure to afford the oily product (R)-1-methyl-3-hydroxypyrrolidine (1.5 g, 92% yield). The product was characterized by 1H NMR (CDCl3, 300 MHz): δ 1.50-1.60 (m, 1H), 1.98-2.10 (m, 1H), 2.25 (s, 3H), 2.25-2.40 (m, 2H), 2.50-2.60 (m, 1H), 2.61-2.70 (m, 1H), 3.80 (brs, 1H), and 4.20-4.30 (m, 1H).

References

[1] Patent: US2007/123557, 2007, A1. Location in patent: Page/Page column 16
[2] Patent: WO2003/87094, 2003, A2. Location in patent: Page/Page column 34

(R)-(-)-1-Methyl-3-pyrrolidinol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-(-)-1-Methyl-3-pyrrolidinol manufacturers

Anhui Dexinjia Biopharm Co., Ltd

Product: (R)-1-Methyl-3-pyrrolidinol 104641-60-3
Price: US $200.00-4000.00/KG
Min. Order: 100KG
Purity: no less than 98%
Supply Ability: 1MT per month
Release date: 2024-07-09

Zibo Hangyu Biotechnology Development Co., Ltd

Product: (R)-(-)-1-Methyl-3-pyrrolidinol 104641-60-3
Price: US $90.00-900.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-08

Career Henan Chemical Co

Product: (R)-(-)-1-Methyl-3-pyrrolidinol 104641-60-3
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-05

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(R)-(?)-1-Methyl-3-pyrrolidinol (R-HNMP)

NMDP =1-Methylpyrrolidin-3-ol Purity:98% (1.5 Kg X 4 batches)

104641-60-3

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Asymmetric Synthesis

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