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LEVCROMAKALIM

Product Name
LEVCROMAKALIM
CAS No.
94535-50-9
Chemical Name
LEVCROMAKALIM
Synonyms
brl38227;lemakalim;Brn 3622889;levcromakelim;LEVCROMAKALIM;LevkroMakaliM;(3s-trans)-yrrolidinyl);Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim;(3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile;(3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
CBNumber
CB5104507
Molecular Formula
C16H18N2O3
Formula Weight
286.33
MOL File
94535-50-9.mol
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LEVCROMAKALIM Property

Melting point:
242-244°
alpha 
D26 -52.2° (c = 1 in chloroform)
Boiling point:
482.3±45.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: ≤10 mM, soluble
form 
solid
pka
13.18±0.60(Predicted)
color 
White to off-white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
DJ2177500
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1378
Product name
Levcromakalim
Purity
≥99%(HPLC)
Packaging
10
Price
$259
Updated
2021/12/16
Tocris
Product number
1378
Product name
Levcromakalim
Purity
≥99%(HPLC)
Packaging
50
Price
$1071
Updated
2021/12/16
TRC
Product number
L331300
Product name
Levcromakalim
Packaging
10mg
Price
$185
Updated
2021/12/16
ChemScene
Product number
CS-6950
Product name
Levcromakalim
Purity
99.79%
Packaging
5mg
Price
$132
Updated
2021/12/16
ChemScene
Product number
CS-6950
Product name
Levcromakalim
Purity
99.79%
Packaging
10mg
Price
$180
Updated
2021/12/16
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LEVCROMAKALIM Chemical Properties,Usage,Production

Uses

Anti-asthmatic; antihypertensive.

Uses

Levcromakalim is a potassium channel activator and vasorelaxant used in the management of hypertension in diabetes mellitus.

Definition

ChEBI: Levcromakalim is a 1-benzopyran.

Biological Activity

Active enantiomer of the prototypical K ATP channel opener cromakalim (trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile ). Hypotensive and airways relaxant. IC 50 = 490 nM in guinea pig trachea.

storage

Store at RT

LEVCROMAKALIM Preparation Products And Raw materials

Raw materials

Preparation Products

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LEVCROMAKALIM Suppliers

China 37 China Hong Kong 1 Germany 1 Switzerland 1 United Kingdom 4 United States 10 Global 54
Tocris Bioscience
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Email
customerservice@tocris.co.uk
Country
United Kingdom
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Leancare Ltd.
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enquiry@leancare.co.uk
Country
United Kingdom
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CARBONE SCIENTIFIC CO.,LTD
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sales@carbonesci.com
Country
United Kingdom
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6666
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UK GREEN SCIENTIFIC CO.,LIMITED
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Email
sales@gs-chem.com
Country
United Kingdom
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6098
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47

94535-50-9, LEVCROMAKALIMRelated Search:

4-TERT-BUTOXYBENZONITRILE 3-(methylaminomethyl)benzonitrile LEVCROMAKALIM 3-M-TOLYL-DL-BETA-ALANINOL 3-CYANOBENZYLAMINE (S)-3-Dimethylamino-3-phenylpropanol 1-Benzyl-2-pyrrolidinone CROMAKALIM (S)-3-(1-Aminoethyl)benzonitrile 4-(2-hydroxyethoxy)benzonitrile 2-(3-CYANO-PHENYL)ETHANOL (2S)-(-)-1-AMINO-3-PHENOXY-2-PROPANOL 4-isopropoxybenzonitrile 1-(3-HYDROXYPROPYL)-2-PYRROLIDONE 3-PYRROLIDINO-1,2-PROPANEDIOL 1-(3-METHOXYPROPYL)-2-PYRROLIDINONE 6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE 4-[3-(Dimethylamino)propoxy]benzonitrile

  • (3S,4R)-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE
  • (3s-trans)-yrrolidinyl)
  • LEVCROMAKALIM
  • 2h-1-benzopyran-6-carbonitrile,3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-p
  • brl38227
  • lemakalim
  • levcromakelim
  • (3S,4R)-3β-Hydroxy-4-(2-oxopyrrolizino)-2,2-dimethyl-3,4-dihydro-6-cyano-2H-1-benzopyran
  • (3β,4α)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-6-carbonitrile
  • (3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
  • 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,trans)-
  • Brn 3622889
  • LevkroMakaliM
  • (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
  • 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,4R)-
  • Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim
  • 94535-50-9
  • Ion Channels
  • Monovalent Ion Channels
  • Potassium Channel Modulators
  • Voltage-gated Ion Channels
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical