5-Chlorofuran-2-carboxylic acid
- Product Name
- 5-Chlorofuran-2-carboxylic acid
- CAS No.
- 618-30-4
- Chemical Name
- 5-Chlorofuran-2-carboxylic acid
- Synonyms
- 5-Chloro-2-furoic acid;5-Chloropyromucic acid;5-chloro-2-furancarboxylate;5-CHLOROFURAN-2-CARBOXYLIC ACID;2-Furancarboxylic acid, 5-chloro-;5-chloro-2-furoic acid(SALTDATA: FREE)
- CBNumber
- CB51091079
- Molecular Formula
- C5H3ClO3
- Formula Weight
- 146.53
- MOL File
- 618-30-4.mol
5-Chlorofuran-2-carboxylic acid Property
- Melting point:
- 179-180 °C
- Boiling point:
- 246.8±20.0 °C(Predicted)
- Density
- 1.515±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO, Methanol (Slightly)
- form
- solid
- pka
- 2.84±0.10(Predicted)
- color
- Pale yellow
Safety
- RIDADR
- 3261
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 2932190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C368425
- Product name
- 5-Chlorofuran-2-carboxylicAcid
- Packaging
- 5g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- 092437
- Product name
- 5-Chlorofuran-2-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- FC140715
- Product name
- 5-Chlorofuran-2-carboxylic acid
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC140715
- Product name
- 5-Chlorofuran-2-carboxylic acid
- Packaging
- 2g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- OR951451
- Product name
- 5-Chloro-2-furoicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
5-Chlorofuran-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
Type of white solid
Uses
5-Chlorofuran-2-carboxylic Acid is used as a reagent in the synthesis of 3-(5-Chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane, a a4b2 nicotinic acetylcholine receptor agonist used for treatment of cognitive disorders.
Synthesis
21508-19-0
618-30-4
Example 7: Synthesis of N-(5-chlorofuran-2-ylcarbonyl)-3,7-diazabicyclo[3.3.0]octane trifluoroacetate Step 1: Preparation of 3,7-diazabicyclo[3.3.0]octane A solution of silver nitrate (8.0 g, 47 mmol) in water (20 mL) was added to 80 mL of 10% aqueous sodium hydroxide and stirred to form a suspension. A 30% aqueous ammonium hydroxide solution was added slowly until the suspension became clear. Step 2: Coupling reaction To the above clarified solution was added a methanol (5mL) solution of 5-chlorofuran-2-carbaldehyde (3.0g, 23mmol, Aldrich Chemical) and stirred for 30 minutes at room temperature. Step 3: Post-treatment The reaction mixture was filtered and the filtrate was washed with ether (100 mL). Subsequently, the aqueous filtrate was adjusted with cold 20% sulfuric acid to a pH of about 3. The acidic aqueous phase was extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, washed with saturated aqueous sodium chloride (100 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 3.2 g (95% yield) of a white solid product with a melting point of 178-179 °C. The product was extracted with ethyl acetate (3 x 100 mL). Remarks: The synthesis method is easy to scale up and has been successfully carried out in several experiments with scale over 10g.
References
[1] Patent: WO2008/57938, 2008, A1. Location in patent: Page/Page column 32
[2] Patent: WO2008/67644, 2008, A1. Location in patent: Page/Page column 36
5-Chlorofuran-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chlorofuran-2-carboxylic acid manufacturers
- Product
- 5-Chlorofuran-2-carboxylic acid 618-30-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-Chlorofuran-2-carboxylic acid 618-30-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-Chlorofuran-2-carboxylic acid 618-30-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09