ChemicalBook > CAS DataBase List > 4-(CHLOROSULFONYL)BENZOIC ACID

4-(CHLOROSULFONYL)BENZOIC ACID

Product Name
4-(CHLOROSULFONYL)BENZOIC ACID
CAS No.
10130-89-9
Chemical Name
4-(CHLOROSULFONYL)BENZOIC ACID
Synonyms
AKOS BB-9471;ClSO2C6H4COOH;RARECHEM AL BO 0540;4-(CHLOROSULFONYL)BE;OTAVA-BB BB7020430958;4-(Chlorsulfonyl)benzoesure;(Chlorosulfonyl)benzoic Acid;4-(chlorosulfonyl)-benzoicaci;P-(CHLOROSULFONYL)BENZOIC ACID;4-(CHLOROSULFONYL)BENZOIC ACID
CBNumber
CB5109294
Molecular Formula
C7H5ClO4S
Formula Weight
220.63
MOL File
10130-89-9.mol
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4-(CHLOROSULFONYL)BENZOIC ACID Property

Melting point:
230 °C
Boiling point:
379.1±25.0 °C(Predicted)
Density 
1.5116 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
soluble in DMSO, Methanol
pka
3.09±0.10(Predicted)
form 
Powder
color 
Off-white to beige
Water Solubility 
Reacts with water.
Sensitive 
Moisture Sensitive
CAS DataBase Reference
10130-89-9(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 4-(chlorosulfonyl)- (10130-89-9)
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Safety

Hazard Codes 
C
Risk Statements 
34-29-22
Safety Statements 
8-45-36/37/39-26
RIDADR 
3261
WGK Germany 
3
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29173990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
252700
Product name
4-(Chlorosulfonyl)benzoic acid
Purity
96%
Packaging
1g
Price
$35.62
Updated
2025/07/31
Sigma-Aldrich
Product number
252700
Product name
4-(Chlorosulfonyl)benzoic acid
Purity
96%
Packaging
5g
Price
$47.88
Updated
2025/07/31
Sigma-Aldrich
Product number
252700
Product name
4-(Chlorosulfonyl)benzoic acid
Purity
96%
Packaging
25g
Price
$104.3
Updated
2025/07/31
TRC
Product number
C383100
Product name
(Chlorosulfonyl)benzoicAcid
Packaging
2.5g
Price
$60
Updated
2021/12/16
AK Scientific
Product number
J96715
Product name
4-(Chlorosulfonyl)benzoic acid
Packaging
10g
Price
$75
Updated
2021/12/16
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4-(CHLOROSULFONYL)BENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

off-white to beige powder

Uses

4-(Chlorosulfonyl)benzoic acid was used in the preparation of polymer bound transfer hydrogenation catalyst and 4-(carboxymethyl-sulfamoyl)-benzoyladenosine. It was also used as a reagent in the sulfonation of γ-cyclodextrin.

Synthesis

104-15-4

10130-89-9

The general procedure for the synthesis of 4-(chlorosulfonyl)benzoic acid from 4-methylphenylsulfonic acid was as follows: a solution of potassium permanganate (KMnO4, 1.6 g) in water (H2O, 13 mL) was added slowly and dropwise at 80 °C to a solution of 4-methylphenylsulfonic acid (1.7 g, 10 mmol) and potassium hydroxide (KOH, 0.68 g, 12 mmol) in water (H2O, a 15 mL) solution. Upon completion of the reaction, the mixture was poured into ethanol (EtOH, 20 mL), filtered and concentrated to give potassium 4-carboxybenzenesulfonate (1.2 g). This intermediate was used directly in the next reaction without further purification. At room temperature, chlorosulfonic acid (4 mL) was slowly added dropwise to a stirring solution of potassium 4-carboxybenzenesulfonate (1.2 g). The reaction mixture was continued to be stirred for 2 hours and then poured into crushed ice. The resulting solid product was collected by filtration and washed with water (H2O) to give 4-(chlorosulfonyl)benzoic acid (0.22 g) as a white solid in 20% yield. The melting point of the product was 230-232 °C (literature value: 228-232 °C); 1H-NMR (CDCl3, 400 MHz) data: δ 8.30 (d, J=8.0 Hz, 2H), 8.42 (d, J=8.0 Hz, 2H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 958 - 962

4-(CHLOROSULFONYL)BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(CHLOROSULFONYL)BENZOIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-(Chlorosulfonyl)benzoic acid 10130-89-9
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-19
Zibo Hangyu Biotechnology Development Co., Ltd
Product
4-(CHLOROSULFONYL)BENZOIC ACID 10130-89-9
Price
US $85.00-850.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-13
Career Henan Chemical Co
Product
4-(Chlorosulfonyl)Benzoic Acid 10130-89-9
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

10130-89-9, 4-(CHLOROSULFONYL)BENZOIC ACIDRelated Search:

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  • 10130-89-9
  • Organic Building Blocks
  • Sulfonyl Halides
  • Sulfur Compounds
  • Building Blocks
  • Organic Building Blocks
  • Sulfonyl Halides
  • Sulfur Compounds