ChemicalBook > CAS DataBase List > 2H-1,4-BENZOXAZIN-3(4H)-ONE

2H-1,4-BENZOXAZIN-3(4H)-ONE

Product Name
2H-1,4-BENZOXAZIN-3(4H)-ONE
CAS No.
5466-88-6
Chemical Name
2H-1,4-BENZOXAZIN-3(4H)-ONE
Synonyms
AURORA KA-5421;4-AZA-3-CHROMANONE;OTAVA-BB BB7020041238;1,4-Benzoxazine-3-one;BENZO[B]MORPHOLIN-3-ONE;2H-1,4-Benzoxazin-3-one;4H-1,4-benzoxazin-3-one;4H-BENZO[1,4]OXAZIN-3-ONE;3-OXO-4H-BENZO[1,4]OXAZINE;2H-1,4-BENZOXAZIN-3(4H)-ONE
CBNumber
CB5111761
Molecular Formula
C8H7NO2
Formula Weight
149.15
MOL File
5466-88-6.mol
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2H-1,4-BENZOXAZIN-3(4H)-ONE Property

Melting point:
173-175 °C(lit.)
Boiling point:
337.7±31.0 °C(Predicted)
Density 
1.244±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
methanol: soluble25mg/mL, clear, colorless
pka
12.89±0.20(Predicted)
form 
Flakes or Powder
color 
White to yellow to tan
λmax
286nm(EtOH)(lit.)
CAS DataBase Reference
5466-88-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
DM3270000
HazardClass 
IRRITANT
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
383503
Product name
2H-1,4-Benzoxazin-3(4H)-one
Purity
99%
Packaging
25g
Price
$25.8
Updated
2024/03/01
Sigma-Aldrich
Product number
383503
Product name
2H-1,4-Benzoxazin-3(4H)-one
Purity
99%
Packaging
5g
Price
$48
Updated
2023/06/20
TCI Chemical
Product number
B4553
Product name
2H-1,4-Benzoxazin-3(4H)-one
Purity
>98.0%(GC)
Packaging
5g
Price
$23
Updated
2024/03/01
TCI Chemical
Product number
B4553
Product name
2H-1,4-Benzoxazin-3(4H)-one
Purity
>98.0%(GC)
Packaging
25g
Price
$69
Updated
2024/03/01
Alfa Aesar
Product number
H27622
Product name
2H-1,4-Benzoxazin-3(4H)-one, 99%
Packaging
5g
Price
$25.65
Updated
2024/03/01
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2H-1,4-BENZOXAZIN-3(4H)-ONE Chemical Properties,Usage,Production

Chemical Properties

white to almost white crystalline powder

Uses

2H-1,4-Benzoxazin-3-one is used to prepare benzoxazinone/benzothiazinone analogs of fluconazole with antifungal and anti-Candida activities. It is used to synthesize 1,?4-?benzoxazine derivatives with vasorelaxant activities.

Synthesis Reference(s)

Synthesis, p. 851, 1984 DOI: 10.1055/s-1984-30993

General Description

2H-1,4-Benzoxazin-3(4H)-one, a benzoxazine derivative, is a heterocyclic building block for various natural and synthetic organic compounds. It has been reported as an intermediate during the biogenesis of cyclic hydoxamic acids in maize. Its standard molar enthalpy of formation and tautomerization energy of its tautomers has been evaluated by calorimetric and computational methods. It has been synthesized by reacting o-aminophenol with chloroacetyl chloride in the presence of butanone and aqueous NaHCO3.

2H-1,4-BENZOXAZIN-3(4H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2H-1,4-BENZOXAZIN-3(4H)-ONE Suppliers

Americas 1 Austria 1 Belgium 1 China 108 Europe 1 France 1 Germany 4 India 34 Japan 2 South Korea 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 12 United States 27 USA 1 Global 197
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View Lastest Price from 2H-1,4-BENZOXAZIN-3(4H)-ONE manufacturers

Career Henan Chemical Co
Product
2H-1,4-BENZOXAZIN-3(4H)-ONE 5466-88-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

5466-88-6, 2H-1,4-BENZOXAZIN-3(4H)-ONERelated Search:

Azasetron hydrochloride 7-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE 2H-1,4-BENZOXAZIN-3(4H)-ONE 7-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE Lensiprazine 7-METHOXY-1,3-BENZOXAZINE-2,4-DIONE 5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE 6-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE 4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE 4-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE 6-CHLORO-2H-1,4-BENZOXAZIN-3(4H)-ONE ETHYL 2-(2,3-DIHYDRO-3-OXOBENZO[B][1,4]OXAZIN-4-YL)ACETATE 5-Nitro-2H-1,4-benzoxazin-3(4H)-one 8-Amino-2,4-dimethyl-2H-1,4-benzoxazin-3(4H)-one 8-Amino-2-methyl-2H-1,4-benzoxazin-3(4H)-one 8-Amino-2H-1,4-benzoxazin-3(4H)-one ETHYL 2-(6-CHLORO-2,3-DIHYDRO-3-OXOBENZO[B][1,4]OXAZIN-4-YL)ACETATE BUTTPARK 5\07-33

  • 4H-BENZO[1,4]OXAZIN-3-ONE
  • 4-AZA-3-CHROMANONE
  • 2H-1,4-BENZOXAZIN-3(4H)-ONE
  • 2H-1,4-BENZOXAZINE-3(4H)-ONE
  • 2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
  • OTAVA-BB BB7020041238
  • BENZO[B]MORPHOLIN-3-ONE
  • AURORA KA-5421
  • JRH-03201, 2H-Benzo[b][1,4]oxazin-3(4H)-one, 97%
  • 2H-1,4-Benzooxazin-3(4H)-one
  • 3-OXO-4H-BENZO[1,4]OXAZINE
  • 2H-1,4-Benzoxazin-3(4H)-one, (4-Aza-3-chromanone)
  • 2,4-Dihydro-3H-1,4-benzoxazine-3-one
  • 3,4-Dihydro-2H-1,4-benzoxazine-3-one
  • 2H-1,4-Benzoxazin-3(4H)-one,99%
  • 2H-1,4-BENZOXAZIN-3(4H)-ONE 99%
  • 3,4-Dihydro-2H-1,4-benzoxazin-3-one
  • 3,4-dihydro-2H-1,4-benzoxazin-3(4H)-one
  • 2H-1,4-Benzoxazin-3(4H)-one (8CI)(9CI)
  • 2H-1,4-Benzoxazin-3-one
  • 4H-1,4-benzoxazin-3-one
  • 2<i>H</i>-1,4-Benzoxazin-3(4<i>H</i>)-one
  • 1,4-Benzoxazine-3-one
  • 2H-1,4-Benzoxazin-3(4H)-one &gt
  • 5466-88-6 2H-1,4-BENZOXAZIN-3(4H)-ONE
  • 2H-1,4-Benzoxazin-3(4H)-one (6CI, 7CI, 8CI, 9CI, ACI)
  • 2H-1,4- 6-Benzoxazin-3(4H)-one
  • 5466-88-6
  • Heterocyclic Building Blocks
  • Building Blocks
  • Benzoxazines
  • pharmacetical
  • API intermediates
  • Miscellaneous
  • Benzoxazines
  • Building Blocks
  • Heterocyclic Building Blocks