2-Hydroxy-5-methylpyridine

Product Name: 2-Hydroxy-5-methylpyridine
CAS No.: 1003-68-5
Chemical Name: 2-Hydroxy-5-methylpyridine
Synonyms: 5-Methylpyridin-2(1H)-one;2(1H)-Pyridinone, 5-methyl-;5-methyl-2-pyridone;2-HYDROXY-5-PICOLINE;AKOS BBS-00002970;2-Hydroxy-5-methyL;5-METHYL-2-PYRIDINOL;6-HYDROXY-3-PICOLINE;5-METHYL-PYRIDIN-2-OL;2-Hydroxy-5-Piocoline
CBNumber: CB5114924
Molecular Formula: C6H7NO
Formula Weight: 109.13
MOL File: 1003-68-5.mol

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2-Hydroxy-5-methylpyridine Property

Melting point:: 183-187 °C (lit.)
Boiling point:: 304.2±15.0 °C(Predicted)
Density: 1.053±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Solid
pka: 12.43±0.10(Predicted)
color: Pale Yellow to Light Yellow
BRN: 107074
InChI: InChI=1S/C6H7NO/c1-5-2-3-6(8)7-4-5/h2-4H,1H3,(H,7,8)
InChIKey: SOHMZGMHXUQHGE-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(C)C=C1
CAS DataBase Reference: 1003-68-5(CAS DataBase Reference)
NIST Chemistry Reference: 2(1H)-pyridinone, 5-methyl-(1003-68-5)

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41-36/37/39
Safety Statements: 26-36-37
WGK Germany: 3
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T162647
Product name: 5-METHYL-2(1H)-PYRIDINONE
Purity: AldrichCPR
Packaging: 1MG
Price: $139
Updated: 2024/03/01

Sigma-Aldrich

Product number: 593427
Product name: 2-Hydroxy-5-methylpyridine
Purity: 97%
Packaging: 1g
Price: $53.8
Updated: 2024/03/01

TCI Chemical

Product number: H1167
Product name: 2-Hydroxy-5-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $22
Updated: 2024/03/01

TCI Chemical

Product number: H1167
Product name: 2-Hydroxy-5-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $69
Updated: 2024/03/01

Alfa Aesar

Product number: L19528
Product name: 2-Hydroxy-5-methylpyridine, 98%
Packaging: 5g
Price: $58.65
Updated: 2024/03/01

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2-Hydroxy-5-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides. 2-hydroxy-5-methylpyridine and Iodobenzene were the impurities present in Pirfenidone (PFD) drug substance. PFD is a novel antifibrotic agent approved for mild to moderate Idiopathic pulmonary fibrosis (IPF) as orphan drug[1].

Definition

ChEBI: 5-Methyl-2-pyridinol is a member of methylpyridines.

Synthesis

3-cyano-6-hydroxypyridine and sodium lauryl sulfate were added to a mixed solvent of n-butanol and water. Subsequently, the temperature was raised to 50 °C., and sulfuric acid water obtained by dissolving 98% sulfuric acid in water was added dropwise at the temperature. After stirring for about 20 minutes, the mixture was cooled to room temperature, and 5% Pd / C was added. The system was replaced with hydrogen, and hydrogenation was carried out at atmospheric pressure for 6 hours. After the reaction was completed, the catalyst was removed by filtration, and the solution was washed with 10% sodium hydroxide aqueous solution. After partially neutralizing to H = 5 and extraction with n-butanol, a solution of crude 3-methyl-6-hydroxypyridine in butanol was obtained. When this solution was quantified by liquid chromatography, the pass-through rate was 99.2%, and the yield of 2-hydroxy-5-methylpyridine was 83%.

References

[1] Suresh Babu Bodempudi, ;K. S. Reddy, Ravichandra Babur. “Development and Substantiation of a RP-HPLC Method for Monitoring of Impurities in Pirfenidone Drug Substance.” 美国分析化学(英文) 6 1 (2015): 1019–1029.

2-Hydroxy-5-methylpyridine Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 2-Hydroxy-5-methylpyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Hydroxy-5-methylpyridine 1003-68-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10kg/month
Release date: 2022-12-28

Suzhou Nordica Biopharma CO.,LTD

Product: 5-methylpyridin-2-ol 1003-68-5
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 0.99
Supply Ability: 1 tons
Release date: 2024-11-15

Shanghai Yongzeng Technology Co.,Ltd

Product: 2-Hydroxy-5-methylpyridine 1003-68-5
Price: US $0.00/gm
Min. Order: 100gm
Purity: 99%min
Supply Ability: 100kgs
Release date: 2024-09-04

1003-68-5, 2-Hydroxy-5-methylpyridineRelated Search:

2-Hydroxypyridine Kresoxim-methyl 2-Hydroxy-5-nitropyridine Methyl acetate 2,6-Lutidine METSULFURON METHYL Tribenuron methyl Azamethiphos CHLOROPHOSPHONAZO III Methyl propyl carbonate Pirimiphos-methyl 4-Methylpyridine 3-Hydroxypyridine 2-Chloro-5-chloromethylpyridine Methyl salicylate Thiophanate-methyl 2,4,6-Collidine 3-Amino-6-hydroxypyridine

6-HYDROXY-3-PICOLINE

5-METHYL-2(1H)PYPRIDINONE

5-METHYL-2(1H)-PYRIDINONE

5-METHYL-2(1H)PYRIDONE

5-METHYL-2-PYRIDINOL

5-METHYL-PYRIDIN-2-OL

5-METHYLPYRIDINE-2-ONE

AKOS BBS-00002970

2-HYDROXY-5-METHYLPYRIDINE

2-HYDROXY-5-PICOLINE

5-methyl-2-pyridone

2-Hydroxy-5-Picoline 2-Hydroxy-5-Methyl Pyridine

2-HYDROXY-5-METHYLPYRIDINE 98%

2-Hydroxy-5-Piocoline

2(1H)-Pyridinone, 5-methyl-

2(1H)-Pyridone, 5-methyl-

2-Methyl-6-hydroxypyridine

5-Methyl-1,2-dihydropyridine-2-one

5-Methylpyridin-2(1H)-one

5-Methylpyridine-2-ol

2-Hydroxy-5-methylpyridine 5-Methyl-2(1H)pypridinone 2-Hydroxy-5-picoline

2-Hydroxy-5-methylpyridine ,98%

1,2-Dihydro-5-methyl-2-oxopyridine

5-Methyl-2-oxopyridine

6-Hydroxy-3-picoline 5-Methyl-2-pyridinol 5-Methyl-2(1H)-pyridinone

Hydroxy-5-Methylpyrid

5-methyl-(1H)pyridinone

Pirfenidone Impurity 2（Pirfenidone EP Impurity B）

2-Hydroxy-5-methyL

(91914-06-6) 2-hydroxy-5-methylpyridine

Perfenidone Impurity 1

5-Methylpyridin-2(1H)-one 98%

2-Hydroxy-5-methylpyridine&gt

2-Hydro-5-methylpyridine

2-Hydroxy-5-methylpyridine ISO 9001：2015 REACH

Big Discount Purity 99% 2-Hydroxy-5-Methylpyridine CAS 1003-68-5 with Best Quality

5-methyl-1,2-dihydropyridin-2-one

2-HYDROXY-5-METHYLPYRIDINEE

Pirfenidone EP Impurity B 5-methylpyridin-2(1H)-one

1003-68-5

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