ChemicalBook > CAS DataBase List > 3-Chlorobenzyl cyanide

3-Chlorobenzyl cyanide

Product Name
3-Chlorobenzyl cyanide
CAS No.
1529-41-5
Chemical Name
3-Chlorobenzyl cyanide
Synonyms
3-Chlorobenzyl;3-Chlorobenzyl cyani;3-Chloroacetonitrile;m-Chlorobenzyl nitrile;3-CHLOROBENZYL CYANIDE;LABOTEST-BB LT00159490;M-CHLOROBENZYL CYANIDE;3-ChlorobenzylCyanide99%;3-CHLOROPHENYLACETONITRILE;3-Chlorobenzyl Cyanide >
CBNumber
CB5115138
Molecular Formula
C8H6ClN
Formula Weight
151.59
MOL File
1529-41-5.mol
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3-Chlorobenzyl cyanide Property

Melting point:
11-13 °C(lit.)
Boiling point:
134-136 °C10 mm Hg(lit.)
Density 
1.283 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.544(lit.)
Flash point:
>230 °F
storage temp. 
Store at room temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
clear liquid
color 
Colorless to Light yellow to Light orange
Specific Gravity
1.280～1.282
BRN 
2042965
Exposure limits
NIOSH: IDLH 25 mg/m3
Stability:
Stable. Incompatible with strong acids, strong bases, strong oxidizing agents, strong reducing agents.
InChIKey
GTIKLPYCSAMPNG-UHFFFAOYSA-N
CAS DataBase Reference
1529-41-5(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetonitrile, 3-chloro-(1529-41-5)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25-36/37/38
Safety Statements 
36/37/39-45-28B
RIDADR 
UN 3276 6.1/PG 1
WGK Germany 
3
RTECS 
AL8240000
HazardClass 
6.1
PackingGroup 
II
HS Code 
29269090
Toxicity
mouse,LD50,intraperitoneal,38mg/kg (38mg/kg),PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGEBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Pesticide Biochemistry and Physiology. Vol. 2, Pg. 95, 1972.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C27808
Product name
(3-Chlorophenyl)acetonitrile
Purity
99%
Packaging
25g
Price
$47.4
Updated
2023/06/20
Sigma-Aldrich
Product number
C27808
Product name
(3-Chlorophenyl)acetonitrile
Purity
99%
Packaging
100g
Price
$168
Updated
2023/06/20
TCI Chemical
Product number
C1091
Product name
3-Chlorobenzyl Cyanide
Purity
>98.0%(GC)
Packaging
25g
Price
$70
Updated
2025/07/31
TRC
Product number
C364455
Product name
3-Chlorobenzyl Cyanide
Packaging
50g
Price
$210
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK141160
Product name
3-Chlorobenzyl Cyanide
Packaging
100g
Price
$214
Updated
2021/12/16
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3-Chlorobenzyl cyanide Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

3-Chlorobenzyl Cyanide is a useful synthetic intermediate. It was used to design EGFR Tyrosine Kinase Inhibitors. It can also be used to synthesize imidoyl thioureas as non-nucleoside reverse transcriptase inhibitors.

Synthesis

773837-37-9

620-20-2

1529-41-5

GENERAL METHOD: 3-chlorobenzyl chloride (1.0 mmol) and sodium cyanide (2 mmol) were dissolved in water (5 mL) and polyethylene glycol modified diisocyanate (PEG-MDIL, 0.2 g) was added. The reaction suspension was magnetically stirred under reflux conditions for the reaction time shown in Table 2. After completion of the reaction, the mixture was extracted with ether (2 × 10 mL). The organic extracts were combined and dried with anhydrous calcium chloride and subsequently concentrated under reduced pressure. By this method, the target product 3-chlorobenzeneacetonitrile was obtained in good to excellent yields (Scheme 3).

References

[1] Journal of Molecular Liquids, 2015, vol. 202, p. 34 - 39

3-Chlorobenzyl cyanide Preparation Products And Raw materials

Raw materials

Preparation Products

2-(3-Chlorophenyl)ethylamine
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3-Chlorobenzyl cyanide Suppliers

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View Lastest Price from 3-Chlorobenzyl cyanide manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
3-Chlorobenzyl cyanide 1529-41-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-27
Hebei Chuanghai Biotechnology Co,.LTD
Product
3-Chlorobenzyl cyanide 1529-41-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-21
Henan Fengda Chemical Co., Ltd
Product
3-Chlorobenzyl cyanide 1529-41-5
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-15

1529-41-5, 3-Chlorobenzyl cyanideRelated Search:

4-(Diethylamino)salicylaldehyde Cyhalothrin Pralmorelin 3-Chlorobenzyl chloride Copper(I) Cyanide 5-Chlorovaleric acid Diphenolic acid DL-α-Tocopherol BETA-CYPERMETHRIN theta-Cypermethrin λ-Cyhalothrin Lorcaserin 5-Methyl Isomer HCl 3-(3-CHLOROPHENYLETHYL)PYRIDINE N-OXIDE 3-Pyridineacrylonitrile, α-(m-chlorophenyl)-β-hydroxy- (8CI) 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride Lorcaserin Impurity 3 Lorcaserin Sulfamate Lorcaserin Impurity 3

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