5-Amino-o-cresol
Application- Product Name
- 5-Amino-o-cresol
- CAS No.
- 2835-95-2
- Chemical Name
- 5-Amino-o-cresol
- Synonyms
- 4-AMINO-2-HYDROXYTOLUENE;5-AMINO-2-METHYLPHENOL;3-HYDROXY-4-METHYLANILINE;JAROCOL 2M5AP;5-AMINO-ORTHO-CRESOL;2-hydroxy-p-toluidine;4-AMINO-2-HRYDROXYTOLUENE;2M5AP;Rodol PAOC;5- aMinocresol
- CBNumber
- CB5116645
- Molecular Formula
- C7H9NO
- Formula Weight
- 123.15
- MOL File
- 2835-95-2.mol
5-Amino-o-cresol Property
- Melting point:
- 160-162 °C(lit.)
- Boiling point:
- 229.26°C (rough estimate)
- Density
- 1.0877 (rough estimate)
- vapor pressure
- 0.002Pa at 25℃
- refractive index
- 1.5380 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 10.36±0.10(Predicted)
- form
- Powder
- color
- Pale brown
- Water Solubility
- 4.11g/L at 20℃
- BRN
- 2802317
- InChIKey
- DBFYESDCPWWCHN-UHFFFAOYSA-N
- LogP
- 0.53 at 20℃
- CAS DataBase Reference
- 2835-95-2(CAS DataBase Reference)
- EPA Substance Registry System
- 5-Amino-2-methylphenol (2835-95-2)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-37/39
- WGK Germany
- 1
- RTECS
- SJ6090000
- TSCA
- Yes
- HS Code
- 29222990
- Hazardous Substances Data
- 2835-95-2(Hazardous Substances Data)
- Toxicity
- bird - domestic,LD50,oral,562mg/kg (562mg/kg),Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 93886
- Product name
- 5-Amino-2-methylphenol
- Purity
- analytical standard
- Packaging
- 100 mg
- Price
- $63.4
- Updated
- 2025/07/31
- Product number
- 225088
- Product name
- 5-Amino-2-methylphenol
- Purity
- 97%
- Packaging
- 5g
- Price
- $81.1
- Updated
- 2025/07/31
- Product number
- 225088
- Product name
- 5-Amino-2-methylphenol
- Purity
- 97%
- Packaging
- 25g
- Price
- $87.1
- Updated
- 2025/07/31
- Product number
- A0925
- Product name
- 5-Amino-o-cresol
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $46
- Updated
- 2025/07/31
- Product number
- A0925
- Product name
- 5-Amino-o-cresol
- Purity
- >98.0%(T)
- Packaging
- 500g
- Price
- $592
- Updated
- 2025/07/31
5-Amino-o-cresol Chemical Properties,Usage,Production
Application
2-Methyl-5-aminophenol is a well-known intermediate among many phenol derivatives. Due to its good biological activity, it is often used as an important raw material or intermediate in the synthesis of pharmaceuticals and pesticides, playing an important role in the synthesis of phenolic drugs.
Chemical Properties
Beige crystals
General Description
Brown powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
5-Amino-o-cresol reacts with strong oxidizing agents.
Fire Hazard
Flash point data are not available for 5-Amino-o-cresol, but 5-Amino-o-cresol is probably combustible.
Flammability and Explosibility
Not classified
Synthesis
95-74-9
2835-95-2
General procedure for the synthesis of 2-methyl-5-aminophenol from 3-chloro-4-methylaniline: 1700 kg of 50% sodium hydroxide solution was added to a 4800 L autoclave, followed by 1850 kg of ethanol solution containing 1000 kg of 3-chloro-4-methylaniline. Then 50kg of cuprous chloride and 15kg of copper powder were added as catalyst. The reaction vessel was sealed and replaced with nitrogen five times to ensure an oxygen-free environment. The reaction mixture was heated to 175°C and maintained at this temperature for 4 hours, during which time it was sampled and analyzed to monitor the progress of the reaction. Upon completion of the reaction, the mixture was cooled to room temperature. Ethanol was recovered under reduced pressure and then the reaction mixture was filtered and transferred to an 8000 L tank. The pH was adjusted to weak acidity by adding 1450 kg of industrial hydrochloric acid to the filtrate. Extraction was carried out with 2000L of ethyl acetate for three times. The organic phases were combined and the ethyl acetate was recovered by distillation under reduced pressure to obtain the crude product. To the crude product, 1000kg of ethanol was added, heated to 60°C to dissolve, and then 50kg of activated carbon was added to decolorize. After stirring for 1 hour, the activated carbon was removed by hot filtration and the filtrate was cooled to 5°C for crystallization. Finally, 707kg of 2-methyl-5-aminophenol was obtained with a yield of 85.36% and a purity of 99.8%.
References
[1] Patent: CN107963974, 2018, A. Location in patent: Paragraph 0030-0032; 0036; 0037
5-Amino-o-cresol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Amino-o-cresol manufacturers
- Product
- 5-Amino-O-Cresol 2835-95-2
- Price
- US $1.00/kg
- Min. Order
- 10kg
- Purity
- 99 %
- Supply Ability
- 10000kg
- Release date
- 2025-06-09
- Product
- 5-Amino-o-cresol 2835-95-2
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%HPLC
- Supply Ability
- 10 TONS
- Release date
- 2021-06-17
- Product
- 5-Amino-o-cresol 2835-95-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-19