Dehydroevodiamine

Product Name: Dehydroevodiamine
CAS No.: 67909-49-3
Chemical Name: Dehydroevodiamine
Synonyms: dehydrovodiamine;Dehydroevodiamine;14-Methyl-5(7H)-oxo-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazoline-14-ium;8,13-Dihydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolinium inner salt;5,7,8,13-Tetrahydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolin-14-ium;Indolo[2',3':3,4]pyrido[2,1-b]quinazolinium,8,13-dihydro-14-methyl-5-oxo-, inner salt;14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]-pyrido[2,1-b]quinazolin-14-ium-13-ide
CBNumber: CB51180199
Molecular Formula: C19H15N3O
Formula Weight: 301.35
MOL File: 67909-49-3.mol

More

Less

Dehydroevodiamine Property

Melting point:: 190-192℃
storage temp.: 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder
color: Yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Usbiological

Product number: 361774
Product name: Dehydroevodiamine
Packaging: 20mg
Price: $263
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD74260
Product name: Dehydroevodiamine
Packaging: 100mg
Price: $231
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb593872
Product name: Dehydroevodiamine
Packaging: 100mg
Price: $306
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0002661
Product name: 14-METHYL-5-OXO-7,8-DIHYDRO-5H-INDOLO-[2',3',3,4]-PYRIDO[2,1-B]QUINAZOLIN-14-IUM-13-IDE
Purity: 95.00%
Packaging: 5MG
Price: $403.06
Updated: 2021/12/16

ChemScene

Product number: CS-0018627
Product name: Dehydroevodiamine
Packaging: 5mg
Price: $50
Updated: 2021/12/16

More

Less

Dehydroevodiamine Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dried near-ripe fruit of Evodia sclerosus.

Uses

Dehydroevodiamine is a novel alkaloid which displays butyrylcholinesterase inhibitory activity in vivo.

Biological Activity

Dehydroevodiamine, a quinazoline alkaloid isolated from Evodiae Fructus, has antiarrhythmic effects on guinea pig ventricular myocytes. It inhibits LPS-induced expression of iNOS, COX-2, PGE2 and NF-κB in mouse macrophages.

Physiological effects

Dehydroevodiamine has an antihypertensive and antitumor effects.

in vitro

Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS -induced increase in the iNOS and COX-2 mRNA expression.

Western Blot Analysis

Cell Line: td>	RAW 264.7 macrophage cells
Concentration:	10 μM, 30 μM, 50 μM
Incubation Time:	pretreated 2 hours
Result:	Reduced iNOS and COX-2 expression and increased IκB-α expression.

RT-PCR

< td class="col1"> Cell Line: td>

RAW 264.7 macrophage cells
Concentration:	10 μM, 30 μM, 50 μM
Incubation Time:	pretreated 2 hours
Result:	Reduced iNOS and COX-2 mRNA expression.

target

Target	Value
NF-κB ()
COX-2 ()
iNOS ()
PGE2 ()

Dehydroevodiamine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Dehydroevodiamine Suppliers

China 116 Germany 1 India 1 United Kingdom 2 United States 7 Global 127

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5182
Advantage: 58

Huzhou ZhanShu Biotechnology Co.,Ltd

Tel: 0572-8889530 18167260939
Email: zsubio@163.com
Country: China
ProdList: 344
Advantage: 58

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4941
Advantage: 60

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19918
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Cheng Du Pufeide Biotechnology Co., Ltd.

Tel: 028-82610909 13388174823
Fax: 8171-1798
Email: scglp@glp-china.com
Country: China
ProdList: 1064
Advantage: 58

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9986
Advantage: 55

More

Less

View Lastest Price from Dehydroevodiamine manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Dehydroevodiamine 67909-49-3
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-09

Career Henan Chemical Co

Product: Dehydroevodiamine 67909-49-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-03

67909-49-3, DehydroevodiamineRelated Search:

Evodol Nomilin EVOLITRINE 14-ForMyldihydrorutaecarpine 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one Evodine RUTAEVIN Dehydrocorydaline Rutaecarpine Evodiamine

Dehydroevodiamine

14-Methyl-5(7H)-oxo-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazoline-14-ium

5,7,8,13-Tetrahydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolin-14-ium

8,13-Dihydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolinium inner salt

14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]-pyrido[2,1-b]quinazolin-14-ium-13-ide

Indolo[2',3':3,4]pyrido[2,1-b]quinazolinium,8,13-dihydro-14-methyl-5-oxo-, inner salt

dehydrovodiamine

67909-49-3

reagent

standard substance