ChemicalBook > CAS DataBase List > Dehydroevodiamine
Dehydroevodiamine
- Product Name
- Dehydroevodiamine
- CAS No.
- 67909-49-3
- Chemical Name
- Dehydroevodiamine
- Synonyms
- dehydrovodiamine;Dehydroevodiamine;14-Methyl-5(7H)-oxo-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazoline-14-ium;8,13-Dihydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolinium inner salt;5,7,8,13-Tetrahydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolin-14-ium;Indolo[2',3':3,4]pyrido[2,1-b]quinazolinium,8,13-dihydro-14-methyl-5-oxo-, inner salt;14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]-pyrido[2,1-b]quinazolin-14-ium-13-ide
- CBNumber
- CB51180199
- Molecular Formula
- C19H15N3O
- Formula Weight
- 301.35
- MOL File
- 67909-49-3.mol
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Dehydroevodiamine Property
- Melting point:
- 190-192℃
- storage temp.
- 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- powder
- color
- Yellow
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N-Bromosuccinimide Price
Usbiological
- Product number
- 361774
- Product name
- Dehydroevodiamine
- Packaging
- 20mg
- Price
- $263
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD74260
- Product name
- Dehydroevodiamine
- Packaging
- 100mg
- Price
- $231
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb593872
- Product name
- Dehydroevodiamine
- Packaging
- 100mg
- Price
- $306
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- INB0002661
- Product name
- 14-METHYL-5-OXO-7,8-DIHYDRO-5H-INDOLO-[2',3',3,4]-PYRIDO[2,1-B]QUINAZOLIN-14-IUM-13-IDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $403.06
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0018627
- Product name
- Dehydroevodiamine
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
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Dehydroevodiamine Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dried near-ripe fruit of Evodia sclerosus.
Uses
Dehydroevodiamine is a novel alkaloid which displays butyrylcholinesterase inhibitory activity in vivo.
Biological Activity
Dehydroevodiamine, a quinazoline alkaloid isolated from Evodiae Fructus, has antiarrhythmic effects on guinea pig ventricular myocytes. It inhibits LPS-induced expression of iNOS, COX-2, PGE2 and NF-κB in mouse macrophages.
Physiological effects
Dehydroevodiamine has an antihypertensive and antitumor effects.
in vitro
Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS -induced increase in the iNOS and COX-2 mRNA expression.
Western Blot Analysis
| Cell Line: td> | RAW 264.7 macrophage cells |
| Concentration: | 10 μM, 30 μM, 50 μM |
| Incubation Time: | pretreated 2 hours |
| Result: | Reduced iNOS and COX-2 expression and increased IκB-α expression. |
RT-PCR
| RAW 264.7 macrophage cells | |
| Concentration: | 10 μM, 30 μM, 50 μM | td>
| Incubation Time: | pretreated 2 hours |
| Result: | Reduced iNOS and COX-2 mRNA expression. |
target
| Target | Value |
| NF-κB () | |
| COX-2 () | |
| iNOS () | |
| PGE2 () |
Dehydroevodiamine Preparation Products And Raw materials
Raw materials
Preparation Products
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Dehydroevodiamine Suppliers
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View Lastest Price from Dehydroevodiamine manufacturers
Shanghai Standard Technology Co., Ltd.
- Product
- Dehydroevodiamine 67909-49-3
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-05-09
Career Henan Chemical Co
- Product
- Dehydroevodiamine 67909-49-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-03
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