Dehydroevodiamine

ChemicalBook > CAS DataBase List > Dehydroevodiamine

Product Name: Dehydroevodiamine
CAS No.: 67909-49-3
Chemical Name: Dehydroevodiamine
Synonyms: dehydrovodiamine;Dehydroevodiamine;14-Methyl-5(7H)-oxo-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazoline-14-ium;8,13-Dihydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolinium inner salt;5,7,8,13-Tetrahydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolin-14-ium;14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]pyrido[2,1-b]quinazolin-14-ium-13-ide;Indolo[2',3':3,4]pyrido[2,1-b]quinazolinium,8,13-dihydro-14-methyl-5-oxo-, inner salt;14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]-pyrido[2,1-b]quinazolin-14-ium-13-ide
CBNumber: CB51180199
Molecular Formula: C19H15N3O
Formula Weight: 301.35
MOL File: 67909-49-3.mol

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Dehydroevodiamine Property

Melting point:: 190-192℃
storage temp.: 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder
color: Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 361774
Product name: Dehydroevodiamine
Packaging: 20mg
Price: $263
Updated: 2021/12/16

ChemScene

Product number: CS-0018627
Product name: Dehydroevodiamine
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0018627
Product name: Dehydroevodiamine
Packaging: 10mg
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD74260
Product name: Dehydroevodiamine
Packaging: 25mg
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD74260
Product name: Dehydroevodiamine
Packaging: 50mg
Price: $136
Updated: 2021/12/16

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Dehydroevodiamine Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dried near-ripe fruit of Evodia sclerosus.

Uses

Dehydroevodiamine is a novel alkaloid which displays butyrylcholinesterase inhibitory activity in vivo.

Biological Activity

Dehydroevodiamine, a quinazoline alkaloid isolated from Evodiae Fructus, has antiarrhythmic effects on guinea pig ventricular myocytes. It inhibits LPS-induced expression of iNOS, COX-2, PGE2 and NF-κB in mouse macrophages.

Physiological effects

Dehydroevodiamine has an antihypertensive and antitumor effects.

in vitro

Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS -induced increase in the iNOS and COX-2 mRNA expression.

Western Blot Analysis

Cell Line: td>	RAW 264.7 macrophage cells
Concentration:	10 μM, 30 μM, 50 μM
Incubation Time:	pretreated 2 hours
Result:	Reduced iNOS and COX-2 expression and increased IκB-α expression.

RT-PCR

< td class="col1"> Cell Line: td>

RAW 264.7 macrophage cells
Concentration:	10 μM, 30 μM, 50 μM
Incubation Time:	pretreated 2 hours
Result:	Reduced iNOS and COX-2 mRNA expression.

target

Target	Value
NF-κB ()
COX-2 ()
iNOS ()
PGE2 ()

Dehydroevodiamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dehydroevodiamine manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Dehydroevodiamine 67909-49-3
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-09

Career Henan Chemical Co

Product: Dehydroevodiamine 67909-49-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-03

67909-49-3, DehydroevodiamineRelated Search:

Evodol Nomilin EVOLITRINE 14-ForMyldihydrorutaecarpine 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one Evodine RUTAEVIN Dehydrocorydaline Rutaecarpine Evodiamine

Dehydroevodiamine

14-Methyl-5(7H)-oxo-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazoline-14-ium

5,7,8,13-Tetrahydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolin-14-ium

8,13-Dihydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolinium inner salt

14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]-pyrido[2,1-b]quinazolin-14-ium-13-ide

Indolo[2',3':3,4]pyrido[2,1-b]quinazolinium,8,13-dihydro-14-methyl-5-oxo-, inner salt

dehydrovodiamine

14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]pyrido[2,1-b]quinazolin-14-ium-13-ide

67909-49-3

reagent

standard substance