ChemicalBook > CAS DataBase List > 4-vinyl-2，3-dihydrobenzofurane

4-vinyl-2，3-dihydrobenzofurane

Product Name: 4-vinyl-2，3-dihydrobenzofurane
CAS No.: 230642-84-9
Chemical Name: 4-vinyl-2，3-dihydrobenzofurane
Synonyms: 4-Vinyl-2,4-dihydrobenzofuran;4-Vinyl-2,3-dihydrobenzofuran;4-ethenyl-2,3-dihydrobenzofuran;Benzofuran, 4-ethenyl-2,3-dihydro-;4-Vinyl-2,3-dihydrobenzofuran(VBF);4-ethenyl-2,3-dihydro-1-benzofuran;4-Ethenyl-2,3-dihydrobenzofuran,98% (stabilized with TBC);Imtermediate tasimelteon(4-ethenyl-2,3-dihydrobenzofuran)
CBNumber: CB51235183
Molecular Formula: C10H10O
Formula Weight: 146.19
MOL File: 230642-84-9.mol

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4-vinyl-2，3-dihydrobenzofurane Property

Boiling point:: 244.3±25.0 °C(Predicted)
Density: 1.078±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: V390000
Product name: 4-Vinyl-2,3-dihydrobenzofuran
Packaging: 5g
Price: $1260
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 62593
Product name: 4-Vinyl-2,3-dihydrobenzofuran
Packaging: 5G
Price: $2200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0078216
Product name: 4-VINYL-2,3-DIHYDROBENZOFURAN
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

Apolloscientific

Product number: OR925611
Product name: 4-Vinyl-2,3-dihydrobenzofuran
Purity: 95%
Packaging: 250mg
Price: $125
Updated: 2021/12/16

AK Scientific

Product number: X4826
Product name: 4-Vinyl-2,3-dihydrobenzofuran
Packaging: 250mg
Price: $153
Updated: 2021/12/16

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4-vinyl-2，3-dihydrobenzofurane Chemical Properties,Usage,Production

Uses

4-Vinyl-2,3-dihydrobenzofuran is an intermediate in the synthesis of tasimelteon (T007740). Tasimelteon is a novel drug, used in the treatment of non-24 hour sleep-wake disorder. It helps to correct the circadian rhythm disorder often seen in patients who are visually impaired.

Synthesis

230642-83-8

230642-84-9

General procedure for the synthesis of 4-vinyl-2,3-dihydrobenzofuran from the compound (CAS: 230642-83-8): dissolve toluene sulfonate of part C (100 g, 314 mmol) in THF (1200 mL) in a 2000 mL three-necked round-bottomed flask equipped with a mechanical stirrer, a digital thermometer, and a homogeneous-pressure charging funnel. Room temperature was maintained. The reaction mixture was cooled to 0 °C via an ice water bath. A THF solution of t-BuOK (1 M, 345.5 mL) was slowly added dropwise at 0 °C for 110 min. The reaction mixture was gradually warmed to ambient temperature and stirring was continued for 2 hours. Upon completion of the reaction, water (350 mL) and EtOAc (600 mL) were added to separate the organic and aqueous layers. The aqueous layer was further extracted with EtOAc (2 x 150 mL). All EtOAc layers were combined, washed with brine (2 × 150 mL), dried over MgSO4 and filtered. The solvent was removed by distillation under reduced pressure to give 46 g of the target product 4-vinyl-2,3-dihydrobenzofuran in 100% yield.

References

[1] Patent: EP1041980, 2005, B1. Location in patent: Page/Page column 33
[2] Journal of Chemical Research, 2016, vol. 40, # 11, p. 667 - 669
[3] Patent: CN106542973, 2017, A. Location in patent: Paragraph 0098-0101

4-vinyl-2，3-dihydrobenzofurane Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-vinyl-2，3-dihydrobenzofurane manufacturers

PNP Biotech Co. Ltd

Product: 4-VINYL-2,3-DIHYDROBENZOFURAN 230642-84-9
Price: US $0.00/KG
Min. Order: 25KG
Purity: 95% HPLC 98%
Supply Ability: Inquiry
Release date: 2023-05-31

Career Henan Chemical Co

Product: 4-vinyl-2，3-dihydrobenzofurane 230642-84-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-20

230642-84-9, 4-vinyl-2，3-dihydrobenzofuraneRelated Search:

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230642-84-9