4-vinyl-2，3-dihydrobenzofurane
- Product Name
- 4-vinyl-2，3-dihydrobenzofurane
- CAS No.
- 230642-84-9
- Chemical Name
- 4-vinyl-2，3-dihydrobenzofurane
- Synonyms
- 4-Vinyl-2,4-dihydrobenzofuran;4-Vinyl-2,3-dihydrobenzofuran;4-ethenyl-2,3-dihydrobenzofuran;Benzofuran, 4-ethenyl-2,3-dihydro-;4-Vinyl-2,3-dihydrobenzofuran(VBF);4-ethenyl-2,3-dihydro-1-benzofuran;4-Ethenyl-2,3-dihydrobenzofuran,98% (stabilized with TBC);Imtermediate tasimelteon(4-ethenyl-2,3-dihydrobenzofuran)
- CBNumber
- CB51235183
- Molecular Formula
- C10H10O
- Formula Weight
- 146.19
- MOL File
- 230642-84-9.mol
4-vinyl-2，3-dihydrobenzofurane Property
- Boiling point:
- 244.3±25.0 °C(Predicted)
- Density
- 1.078±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- V390000
- Product name
- 4-Vinyl-2,3-dihydrobenzofuran
- Packaging
- 5g
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- 62593
- Product name
- 4-Vinyl-2,3-dihydrobenzofuran
- Packaging
- 5G
- Price
- $2200
- Updated
- 2021/12/16
- Product number
- CHM0078216
- Product name
- 4-VINYL-2,3-DIHYDROBENZOFURAN
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- OR925611
- Product name
- 4-Vinyl-2,3-dihydrobenzofuran
- Purity
- 95%
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- X4826
- Product name
- 4-Vinyl-2,3-dihydrobenzofuran
- Packaging
- 250mg
- Price
- $153
- Updated
- 2021/12/16
4-vinyl-2，3-dihydrobenzofurane Chemical Properties,Usage,Production
Uses
4-Vinyl-2,3-dihydrobenzofuran is an intermediate in the synthesis of tasimelteon (T007740). Tasimelteon is a novel drug, used in the treatment of non-24 hour sleep-wake disorder. It helps to correct the circadian rhythm disorder often seen in patients who are visually impaired.
Synthesis
230642-83-8
230642-84-9
General procedure for the synthesis of 4-vinyl-2,3-dihydrobenzofuran from the compound (CAS: 230642-83-8): dissolve toluene sulfonate of part C (100 g, 314 mmol) in THF (1200 mL) in a 2000 mL three-necked round-bottomed flask equipped with a mechanical stirrer, a digital thermometer, and a homogeneous-pressure charging funnel. Room temperature was maintained. The reaction mixture was cooled to 0 °C via an ice water bath. A THF solution of t-BuOK (1 M, 345.5 mL) was slowly added dropwise at 0 °C for 110 min. The reaction mixture was gradually warmed to ambient temperature and stirring was continued for 2 hours. Upon completion of the reaction, water (350 mL) and EtOAc (600 mL) were added to separate the organic and aqueous layers. The aqueous layer was further extracted with EtOAc (2 x 150 mL). All EtOAc layers were combined, washed with brine (2 × 150 mL), dried over MgSO4 and filtered. The solvent was removed by distillation under reduced pressure to give 46 g of the target product 4-vinyl-2,3-dihydrobenzofuran in 100% yield.
References
[1] Patent: EP1041980, 2005, B1. Location in patent: Page/Page column 33
[2] Journal of Chemical Research, 2016, vol. 40, # 11, p. 667 - 669
[3] Patent: CN106542973, 2017, A. Location in patent: Paragraph 0098-0101
4-vinyl-2，3-dihydrobenzofurane Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-vinyl-2，3-dihydrobenzofurane manufacturers
- Product
- 4-VINYL-2,3-DIHYDROBENZOFURAN 230642-84-9
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 95% HPLC 98%
- Supply Ability
- Inquiry
- Release date
- 2023-05-31
- Product
- 4-vinyl-2，3-dihydrobenzofurane 230642-84-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20