Mazdutide
- Product Name
- Mazdutide
- CAS No.
- 2259884-03-0
- Chemical Name
- Mazdutide
- Synonyms
- Mazdutide;Mazdutide acetate
- CBNumber
- CB512574545
- Formula Weight
- 0
- MOL File
- Mol file
Mazdutide Chemical Properties,Usage,Production
Description
Mazdutide (also known as IBI362 or LY3305677), a novel once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist, achieved 12-week body weight loss of up to 6.4% at doses up to 6 mg in Chinese adults with overweight or obesity. It is the first GLP-1R/GCGR dual agonist to succeed in Phase 3 trials. As mazdutide's first registrational trial for weight management, the results of GLORY-1 not only further confirm the efficacy and safety of the mazdutide in a large population but also provide high-quality clinical evidence of long-term pharmacotherapy weight management specifically for the Chinese population with overweight or obesity[1].
Biological Functions
As a mammalian oxyntomodulin (OXM) analog, in addition to the effects of GLP-1 receptor agonists on promoting insulin secretion, lowering blood glucose, and reducing body weight, mazdutide may also increase energy expenditure and improve hepatic fat metabolism through the activation of glucagon receptor. Mazdutide has demonstrated robust weight loss and glucose-lowering effects in clinical studies, as well as multiple cardio-metabolic benefits, including reducing waist circumference, blood lipids, blood pressure, blood uric acid, liver enzymes, liver fat content and improving insulin sensitivity.
References
[1] Linong Ji. “Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple-ascending-dose phase 1b trial.” EClinicalMedicine (2022): 101691.
Mazdutide Preparation Products And Raw materials
Raw materials
Preparation Products
Mazdutide Suppliers
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- 17326133519
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- Country
- China
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- 025-025-58361106-805-805 13082558573
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- 025-58361106-806
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- China
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- China
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- 1-631-614-7828
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- United States
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- 0571-88211921 13355716090
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- China
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- 0571-87213919 17306812703
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- Country
- China
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- 5950
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View Lastest Price from Mazdutide manufacturers
- Product
- mazdutide 2259884-03-0
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20ton
- Release date
- 2024-03-29
- Product
- Mazdutide 2259884-03-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >99%
- Supply Ability
- 5kg
- Release date
- 2024-01-13
- Product
- Mazdutide 2259884-03-0
- Price
- US $20.00-9000.00/vial
- Min. Order
- 10vial
- Purity
- 99.99%
- Supply Ability
- 90000kit
- Release date
- 2023-08-24