Mazdutide

clinical trial

Product Name: Mazdutide
CAS No.: 2259884-03-0
Chemical Name: Mazdutide
Synonyms: Mazdutide;Mazdutide 10mg;Mazdutide acetate;Mazdutide 5mg 10mg
CBNumber: CB512574545
Formula Weight: 0
MOL File: Mol file

More

Less

Mazdutide Property

solubility: PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
form: Solid
color: White to off-white
Sequence: His-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys-{AEEA-AEEA-γGlu-Nonadecanoic acid}-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

Mazdutide Chemical Properties,Usage,Production

clinical trial

Mazdutide (IBI362 or LY3305677) is a synthetic peptide analogue of mammalian oxyntomodulin and a once-weekly GLP-1 and glucagon receptor dual agonist. In a 12-week multiple-ascending-dose phase 1b study in Chinese patients with type 2 diabetes (clinical trial reg. no. NCT04466904, clinicaltrials.gov), mean changes in HbA1c ranged from −1.46% to −2.23% with mazdutide (−1.98% with 1.5 mg dulaglutide and −0.87% with placebo). Mean changes in body weight were up to −5.4% with mazdutide, −0.9% with dulaglutide, and −1.1% with placebo. A 12- to 16-week phase 1b study in Western patients with type 2 diabetes (clinical trial reg. no. NCT03928379, clinicaltrials.gov) reported mean changes in HbA1c up to −2.16% with mazdutide (−0.70% with placebo) and mean changes in body weight up to −11.2 kg with mazdutide (−2.0 kg with placebo). In both studies, mazdutide was well tolerated, with gastrointestinal adverse events most frequently reported.

Description

Mazdutide (also known as IBI362 or LY3305677), a novel once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist, achieved 12-week body weight loss of up to 6.4% at doses up to 6 mg in Chinese adults with overweight or obesity. It is the first GLP-1R/GCGR dual agonist to succeed in Phase 3 trials. As mazdutide's first registrational trial for weight management, the results of GLORY-1 not only further confirm the efficacy and safety of the mazdutide in a large population but also provide high-quality clinical evidence of long-term pharmacotherapy weight management specifically for the Chinese population with overweight or obesity[1].

Uses

Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D)[1][2][3].

Biological Functions

As a mammalian oxyntomodulin (OXM) analog, in addition to the effects of GLP-1 receptor agonists on promoting insulin secretion, lowering blood glucose, and reducing body weight, mazdutide may also increase energy expenditure and improve hepatic fat metabolism through the activation of glucagon receptor. Mazdutide has demonstrated robust weight loss and glucose-lowering effects in clinical studies, as well as multiple cardio-metabolic benefits, including reducing waist circumference, blood lipids, blood pressure, blood uric acid, liver enzymes, liver fat content and improving insulin sensitivity.

Side effects

Compared to placebo, it was also associated with reductions in fasting plasma glucose and HbA1c among patients with diabetes. Mazdutide was associated with more side effects, primarily gastrointestinal-related disorders, such as decreased appetite, nausea, vomiting and diarrhea. Moreover, all participants on Mazdutide experienced an increase in heart rates. However, these side effects were transient and mild to moderate in severity, and no participant discontinued treatment due to the side effects[2].

in vivo

Mazdutide (15, 30 nmol/kg; sc; single dose) significantly reduces body weight and physical intake in diabetic mice with diet-induced obesity (DIO)^[3].

References

[1] Linong Ji. “Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple-ascending-dose phase 1b trial.” EClinicalMedicine (2022): 101691.
[2] LINONG JI. IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase 1b study.[J]. EClinicalMedicine, 2021: 101088. DOI: 10.1016/j.eclinm.2021.101088

Mazdutide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Mazdutide Suppliers

China 79 United States 3 Global 82

Zhejiang Jiekun Biotechnology Co., Ltd

Tel: 0571-88211951 13735575465
Email: sales1@gotopbio.com
Country: China
ProdList: 4880
Advantage: 58

Shaoxing Junyu Biotechnology Co., LTD

Tel: 0571-0571-88211921 19105816207
Email: sales4@gotopbio.com
Country: China
ProdList: 5144
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 15397062932
Email: sales1@gotopbio.com
Country: China
ProdList: 2923
Advantage: 58

Hangzhou Xinhai Pharmaceutical Technology Co., Ltd.

Tel: 0571-86758863 13867485072
Fax: 0571-86758863
Email: lulu@thinheal.com
Country: China
ProdList: 262
Advantage: 58

Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Tel: 0571-87213919 17306812703
Email: 3007955328@qq.com
Country: China
ProdList: 6979
Advantage: 58

Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd

Tel: 13770887460
Email: wenxi@jszkhy.com
Country: China
ProdList: 1354
Advantage: 58

Nanjing Yuanpeptide Biotech Co.，Ltd.

Tel: 18168071971
Email: support@yuan-peptide.com
Country: China
ProdList: 2983
Advantage: 58

Zhangzhou Sinobioway Peptide Co. Ltd.

Tel: 18750546777; 18750546777
Email: SINOPEPT@GMAIL.COM
Country: China
ProdList: 6093
Advantage: 58

Nanjing Typeptide Biotechnology Co.,Ltd.

Tel: 19941518170
Email: sales@typeptide.com
Country: China
ProdList: 3920
Advantage: 58

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

More

Less

View Lastest Price from Mazdutide manufacturers

Hebei Dangtong Import and export Co LTD

Product: Mazdutide 2259884-03-0
Price: US $485.00-4250.00/g
Min. Order: 0.1g
Purity: 99%
Supply Ability: 50g
Release date: 2025-10-31

Shanghai Yimeixin Technology Co., LTD

Product: Mazdutide 2259884-03-0
Price: US $0.00/box
Min. Order: 1box
Purity: 0.99
Supply Ability: 10tons
Release date: 2025-09-26

Hebei Lutong Import and Export Co., Ltd

Product: Mazdutide 2259884-03-0
Price: US $75.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-09-25

2259884-03-0, MazdutideRelated Search:

GLP-1 GLP-1（Glucagon-like peptide-1）(7-36) glucagon-like peptide 1 H-HIS-ASP-GLU-PHE-GLU-ARG-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-NH2 Utreglutide L-Threonine, L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-2-methylalanyl-L-alanyl-L-arginyl-L-alanyl-L-α-glutamyl-L-α-glutamyl-L-phenylalanyl-L-valyl-L-lysyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-seryl- GLUCAGON HYDROCHLORIDE(HUMAN) H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-TyrLeu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-LeuVal-Lys-Gly-Arg-Lys(biotinyl)-NH2 (MET(O)27)-GLUCAGON (1-29) (HUMAN, BOVINE, PORCINE) tLyP-1 peptide

Mazdutide

Mazdutide acetate

Mazdutide 10mg

Mazdutide 5mg 10mg

2259884-03-0