DPQ

ChemicalBook > CAS DataBase List > DPQ

Product Name: DPQ
CAS No.: 129075-73-6
Chemical Name: DPQ
Synonyms: DPQ;DMEM(Low Glucose);PARP Inhibitor III, DPQ;PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem;3,4-DIHYDRO-5[4-(1-PIPERINDINYL)BUTOXY]-1(2H)-ISOQUINOLINE;3,4-DIHYDRO-5[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINE;5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one;3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXY]-1(2H)-ISOQUINOLINONE;3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINONE;1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-
CBNumber: CB5126204
Molecular Formula: C18H26N2O2
Formula Weight: 302.41
MOL File: 129075-73-6.mol

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DPQ Property

Melting point:: 107-109°
Boiling point:: 528.8±50.0 °C(Predicted)
Density: 1.096±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: Soluble
form: solid
pka: 14.54±0.20(Predicted)
color: White to off-white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D5314
Product name: DPQ
Purity: ≥98% (HPLC), solid
Packaging: 1mg
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: 300270
Product name: PARP Inhibitor III, DPQ
Packaging: 1mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 14450
Product name: DPQ
Purity: ≥99%
Packaging: 1mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 14450
Product name: DPQ
Purity: ≥99%
Packaging: 5mg
Price: $201
Updated: 2024/03/01

Sigma-Aldrich

Product number: D5314
Product name: DPQ
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $443
Updated: 2024/03/01

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DPQ Chemical Properties,Usage,Production

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC₅₀ value of 40 nM. It is approximately 10-fold less potent against PARP2. DPQ can be used in either cells or in animals.

Uses

DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.

Uses

3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone is a potent inhibitor of poly(ADP-ribose) polymerases, a family of enzymes that plays a crucial role in DNA repair and apoptosis in respons e to reactive oxygen and nitrogen species.

Uses

Reagent for inhibition of PARP.

Biochem/physiol Actions

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.

storage

+4°C

DPQ Preparation Products And Raw materials

Raw materials

Preparation Products

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DPQ Suppliers

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129075-73-6, DPQRelated Search:

4-AMINO-1,8-NAPHTHALIMIDE 3-Aminobenzamide NU1025 DMEM/F12 medium DMEM medium 4-Hydroxyquinazoline Rucaparib ABT-888 1,5-ISOQUINOLINEDIOL 1(2H)-Isoquinolinone, 5-aMino-, Monohydrochloride 5-Benzoyloxy-1(2H)-isoquinolinone 3-(4-CHLORO-PHENYL)-QUINOXALINE-5-CARBOXYLIC ACID AMIDE TIQ-A 5-METHOXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE DPQ 5-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 1,2,3,4-TETRAHYDRO-ISOQUINOLIN-5-OL DULBECCO'S MODIFIED EAGLE'S MEDIUM W/L-&

PARP Inhibitor III, DPQ

5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one

DPQ

3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXY]-1(2H)-ISOQUINOLINONE

3,4-DIHYDRO-5[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINE

3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINONE

3,4-DIHYDRO-5[4-(1-PIPERINDINYL)BUTOXY]-1(2H)-ISOQUINOLINE

5-[4-(1-PIPERIDINYL)-BUTYLOXY]-1,2,3,4-TETRAHYDROISOQUINOLIN-1-ONE

PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem

1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-

DMEM(Low Glucose)

129075-73-6

BioChemical

Apoptosis and Cell Cycle

Cell Biology

Cell Signaling and Neuroscience

PARP Regulators

PARP