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Methyl 5-fluoropicolinate

Product Name
Methyl 5-fluoropicolinate
CAS No.
107504-07-4
Chemical Name
Methyl 5-fluoropicolinate
Synonyms
Methyl 5-fluoropicolinate;Methyl 5-fluoropyridine-2-carboxylate;5-fluoropyridine methyl formate;5-fluoropyridolinate methyl ester;methyl 5-fluoro-2-pyridinecarboxylate;5-fluoro-2-pyridinecarboxylic acid methy;5-Fluoropyridine-2-carboxylic acid methyl ester;5-fluoro-2-pyridinecarboxylic acid methyl ester;2-PYRIDINECARBOXYLIC ACID, 5-FLUORO-, METHYL ESTER;2-Pyridinecarboxylicacid,5-fluoro-,methylester(9CI)
CBNumber
CB51289580
Molecular Formula
C7H6FNO2
Formula Weight
155.13
MOL File
107504-07-4.mol
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Methyl 5-fluoropicolinate Property

Boiling point:
217.2±20.0 °C(Predicted)
Density 
1.243±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
-0.73±0.10(Predicted)
form 
solid
color 
Off-white
InChI
InChI=1S/C7H6FNO2/c1-11-7(10)6-3-2-5(8)4-9-6/h2-4H,1H3
InChIKey
KCMBKUFSDZMQEM-UHFFFAOYSA-N
SMILES
C1(C(OC)=O)=NC=C(F)C=C1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
M305388
Product name
Methyl5-fluoropicolinate
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
M305388
Product name
Methyl5-fluoropicolinate
Packaging
1g
Price
$75
Updated
2021/12/16
TRC
Product number
M305388
Product name
Methyl5-fluoropicolinate
Packaging
500mg
Price
$65
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
35716
Product name
Methyl5-fluoropicolinate
Purity
95+%
Packaging
5G
Price
$1050
Updated
2021/12/16
ChemScene
Product number
CS-0018830
Product name
Methyl5-fluoropicolinate
Packaging
10g
Price
$296
Updated
2021/12/16
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Methyl 5-fluoropicolinate Chemical Properties,Usage,Production

Uses

Methyl 5-fluoropicolinate is a fluoroorganic heterocyclic compound that can be used in the preparation of BTK inhibitors or degradation agents for the treatment of BTK-related diseases such as tumours or autoimmune system disorders.

Synthesis

107504-08-5

67-56-1

107504-07-4

General procedure for the synthesis of methyl 5-fluoropyridinecarboxylate: 5 g of 5-fluoropyridine-2-carboxylic acid was added to 50 mL of methanol and 2.7 mL of thionyl chloride was added slowly and dropwise. The reaction mixture was transferred to a sealed microwave reaction flask and the reaction was stirred at 65 °C for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in a solvent mixture of dichloromethane and methanol and filtered through a silica gel column. The filtrate was collected and concentrated under reduced pressure to give 5.9 g of the target compound, methyl 5-fluoropyridinecarboxylate. Thin layer chromatography showed an Rf value of 0.77 (Method K). Mass spectrometry analysis showed a molecular ion peak (M + H)+ of 156.

References

[1] Patent: WO2013/79460, 2013, A1. Location in patent: Page/Page column 46
[2] Patent: US2013/137688, 2013, A1. Location in patent: Paragraph 0239; 0240; 0241
[3] Patent: CN108003161, 2018, A. Location in patent: Paragraph 0628; 0630-0632

Methyl 5-fluoropicolinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 5-fluoropicolinate Suppliers

China 117 Europe 1 Germany 1 India 1 United Kingdom 2 United States 10 Global 132
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
Atlantic Research Chemicals Ltd.
Tel
--
Fax
--
Email
info@atlantic-chemicals.com
Country
United Kingdom
ProdList
5618
Advantage
63
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View Lastest Price from Methyl 5-fluoropicolinate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Methyl 5-fluoro-2-pyridinecarboxylate 107504-07-4
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-24
Career Henan Chemical Co
Product
2-Pyridinecarboxylicacid,5-fluoro-,methylester(9CI) 107504-07-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-05-25

107504-07-4, Methyl 5-fluoropicolinateRelated Search:

2-Pyridinecarboxylic acid, 4-bromo-5-chloro-, methyl ester 2-Pyridinecarboxylic acid, 4-chloro-5-(1,3-dioxolan-2-yl)- 2-Pyridinecarboxamide,5-fluoro-(9CI) 5-Fluoro-2-forMylpyridine METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE 3-FLUORO-5-FORMYLPYRIDINE 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE

  • 2-Pyridinecarboxylicacid,5-fluoro-,methylester(9CI)
  • 5-Fluoropyridine-2-carboxylic acid methyl ester
  • Methyl 5-fluoropicolinate
  • Methyl 5-fluoropyridine-2-carboxylate
  • 5-fluoro-2-pyridinecarboxylic acid methy
  • 2-PYRIDINECARBOXYLIC ACID, 5-FLUORO-, METHYL ESTER
  • 5-fluoro-2-pyridinecarboxylic acid methyl ester
  • methyl 5-fluoro-2-pyridinecarboxylate
  • 5-fluoropyridine methyl formate
  • 5-fluoropyridolinate methyl ester
  • 107504-07-4
  • HALIDE