Methyl 5-fluoropicolinate

Product Name: Methyl 5-fluoropicolinate
CAS No.: 107504-07-4
Chemical Name: Methyl 5-fluoropicolinate
Synonyms: Methyl 5-fluoropicolinate;Methyl 5-fluoropyridine-2-carboxylate;5-fluoropyridine methyl formate;5-fluoropyridolinate methyl ester;methyl 5-fluoro-2-pyridinecarboxylate;5-fluoro-2-pyridinecarboxylic acid methy;5-Fluoropyridine-2-carboxylic acid methyl ester;5-fluoro-2-pyridinecarboxylic acid methyl ester;2-PYRIDINECARBOXYLIC ACID, 5-FLUORO-, METHYL ESTER;2-Pyridinecarboxylicacid,5-fluoro-,methylester(9CI)
CBNumber: CB51289580
Molecular Formula: C7H6FNO2
Formula Weight: 155.13
MOL File: 107504-07-4.mol

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Methyl 5-fluoropicolinate Property

Boiling point:: 217.2±20.0 °C(Predicted)
Density: 1.243±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: -0.73±0.10(Predicted)
form: solid
color: Off-white
InChI: InChI=1S/C7H6FNO2/c1-11-7(10)6-3-2-5(8)4-9-6/h2-4H,1H3
InChIKey: KCMBKUFSDZMQEM-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC=C(F)C=C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M305388
Product name: Methyl5-fluoropicolinate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M305388
Product name: Methyl5-fluoropicolinate
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: M305388
Product name: Methyl5-fluoropicolinate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35716
Product name: Methyl5-fluoropicolinate
Purity: 95+%
Packaging: 5G
Price: $1050
Updated: 2021/12/16

ChemScene

Product number: CS-0018830
Product name: Methyl5-fluoropicolinate
Packaging: 10g
Price: $296
Updated: 2021/12/16

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Methyl 5-fluoropicolinate Chemical Properties,Usage,Production

Uses

Methyl 5-fluoropicolinate is a fluoroorganic heterocyclic compound that can be used in the preparation of BTK inhibitors or degradation agents for the treatment of BTK-related diseases such as tumours or autoimmune system disorders.

Synthesis

107504-08-5

67-56-1

107504-07-4

General procedure for the synthesis of methyl 5-fluoropyridinecarboxylate: 5 g of 5-fluoropyridine-2-carboxylic acid was added to 50 mL of methanol and 2.7 mL of thionyl chloride was added slowly and dropwise. The reaction mixture was transferred to a sealed microwave reaction flask and the reaction was stirred at 65 °C for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in a solvent mixture of dichloromethane and methanol and filtered through a silica gel column. The filtrate was collected and concentrated under reduced pressure to give 5.9 g of the target compound, methyl 5-fluoropyridinecarboxylate. Thin layer chromatography showed an Rf value of 0.77 (Method K). Mass spectrometry analysis showed a molecular ion peak (M + H)+ of 156.

References

[1] Patent: WO2013/79460, 2013, A1. Location in patent: Page/Page column 46
[2] Patent: US2013/137688, 2013, A1. Location in patent: Paragraph 0239; 0240; 0241
[3] Patent: CN108003161, 2018, A. Location in patent: Paragraph 0628; 0630-0632

Methyl 5-fluoropicolinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 5-fluoropicolinate Suppliers

China 117 Europe 1 Germany 1 India 1 United Kingdom 2 United States 10 Global 132

Accela ChemBio Inc.

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View Lastest Price from Methyl 5-fluoropicolinate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Methyl 5-fluoro-2-pyridinecarboxylate 107504-07-4
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-24

Career Henan Chemical Co

Product: 2-Pyridinecarboxylicacid,5-fluoro-,methylester(9CI) 107504-07-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-05-25

107504-07-4, Methyl 5-fluoropicolinateRelated Search:

2-Pyridinecarboxylic acid, 4-bromo-5-chloro-, methyl ester 2-Pyridinecarboxylic acid, 4-chloro-5-(1,3-dioxolan-2-yl)- 2-Pyridinecarboxamide,5-fluoro-(9CI) 5-Fluoro-2-forMylpyridine METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE 3-FLUORO-5-FORMYLPYRIDINE 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE

2-Pyridinecarboxylicacid,5-fluoro-,methylester(9CI)

5-Fluoropyridine-2-carboxylic acid methyl ester

Methyl 5-fluoropicolinate

Methyl 5-fluoropyridine-2-carboxylate

5-fluoro-2-pyridinecarboxylic acid methy

2-PYRIDINECARBOXYLIC ACID, 5-FLUORO-, METHYL ESTER

5-fluoro-2-pyridinecarboxylic acid methyl ester

methyl 5-fluoro-2-pyridinecarboxylate

5-fluoropyridine methyl formate

5-fluoropyridolinate methyl ester

107504-07-4

HALIDE