5-Amino-2-bromo-6-picoline
- Product Name
- 5-Amino-2-bromo-6-picoline
- CAS No.
- 126325-47-1
- Chemical Name
- 5-Amino-2-bromo-6-picoline
- Synonyms
- EOS-60356;3-Amino-6-bromo-2-methyL;6-Bromo-5-amino-2-picoline;3-AMINO-6-BROMO-2-PICOLINE;5-AMINO-2-BROMO-6-PICOLINE;6-Bromo-2-methyl-3-pyridinamine;6-broMo-2-Methyl-3-aMinopyridine;3-AMINO-6-BROMO-2-METHYLPYRIDINE;6-bromo-2-methylpyridine-3-amine;2-Bromo-5-amino-6-methylpyridine
- CBNumber
- CB5137022
- Molecular Formula
- C6H7BrN2
- Formula Weight
- 187.04
- MOL File
- 126325-47-1.mol
5-Amino-2-bromo-6-picoline Property
- Melting point:
- 110-111℃
- Boiling point:
- 284.4±35.0 °C(Predicted)
- Density
- 1.593±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.45±0.10(Predicted)
- form
- Solid
- color
- Off-white
- CAS DataBase Reference
- 126325-47-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-41-37/38-22
- Safety Statements
- 26-36-39
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A2928
- Product name
- 3-Amino-6-bromo-2-methylpyridine
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $44
- Updated
- 2025/07/31
- Product number
- A2928
- Product name
- 3-Amino-6-bromo-2-methylpyridine
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $132
- Updated
- 2025/07/31
- Product number
- A594935
- Product name
- 5-Amino-2-bromo-6-picoline
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 040412
- Product name
- 5-Amino-2-bromo-6-picoline
- Purity
- 98%
- Packaging
- 10g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FA40236
- Product name
- 5-AmiNo-2-bromo-6-picoliNe
- Packaging
- 2g
- Price
- $79.4
- Updated
- 2021/12/16
5-Amino-2-bromo-6-picoline Chemical Properties,Usage,Production
Chemical Properties
crystalline powder
Uses
5-Amino-2-bromo-6-picoline is a useful research intermediate.
Synthesis
22282-96-8
126325-47-1
General procedure for the synthesis of 2-bromo-5-amino-6-methylpyridine from 2-bromo-5-nitro-6-methylpyridine: 6-bromo-2-methyl-3-nitropyridine (XIV) (250 g, 1.15 mol, 1.00 equiv) and NH4Cl (300 g, 5.61 mol, 4.88 equiv) were suspended in a mixture of EtOH (3.50 L) and water ( 150 mL) in a solvent mixture. The suspension was heated to 65 °C under stirring. Subsequently, Fe (130 g, 2.33 mol, 2.02 eq.) and HCl (15.3 g, 419 mmol, 0.36 eq.) were added to the reaction system. The reaction mixture was heated to 80 °C and maintained at this temperature for 3 hours. After completion of the reaction, the mixture was cooled to 25 °C and filtered through a diatomaceous earth plug. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was dissolved in EtOAc (1 L x 3) and washed with brine. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 6-bromo-2-methylpyridin-3-amine (XV) as a brown solid (373 g, 1.99 mol, 86.7% yield), which could be used in the next reaction without further purification.1H NMR (DMSO-d6, 400 MHz) δ ppm: 6.01 (dd, J = 2.3, 7.9 Hz, 2H). 7.9 Hz, 2H), 7.03 (d, J = 8.2 Hz, 1H); ESIMS m/z: 186.8 ([M + H]+).
References
[1] Patent: WO2017/23993, 2017, A1. Location in patent: Paragraph 0615; 0616
[2] Patent: WO2017/24004, 2017, A1. Location in patent: Paragraph 0610-0611
[3] Patent: WO2017/24025, 2017, A1. Location in patent: Paragraph 0611
[4] Patent: WO2017/24003, 2017, A1. Location in patent: Paragraph 0610; 0611
[5] Patent: US2016/347717, 2016, A1. Location in patent: Paragraph 0593; 0594
5-Amino-2-bromo-6-picoline Preparation Products And Raw materials
Raw materials
Preparation Products
5-Amino-2-bromo-6-picoline Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 5-Amino-2-bromo-6-picoline manufacturers
- Product
- 5-Amino-2-bromo-6-picoline 126325-47-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-04
- Product
- 5-Amino-2-bromo-6-picoline 126325-47-1
- Price
- US $6.00-0.20/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-03
- Product
- 5-Amino-2-bromo-6-picoline 126325-47-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-25