licoricidin
- Product Name
- licoricidin
- CAS No.
- 30508-27-1
- Chemical Name
- licoricidin
- Synonyms
- licoricidin;Licorisoflavan B;LICORICIDIN (LCD);7-O-Demethyllicorisoflavan A;1,3-Benzenediol,4-[(3R)-3,4-dihydro-7-hydroxy-5-methoxy-6-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-3-yl]-2-(3-methyl-2-buten-1-yl)-
- CBNumber
- CB51380788
- Molecular Formula
- C26H32O5
- Formula Weight
- 424.53
- MOL File
- 30508-27-1.mol
licoricidin Property
- Melting point:
- 161.0-162.5℃
- Boiling point:
- 610.8±55.0 °C(Predicted)
- Density
- 1.171±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 10.10±0.40(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CFN96389
- Product name
- Licoricidin
- Packaging
- 5mg
- Price
- $388
- Updated
- 2021/12/16
- Product number
- CD32001693
- Product name
- Licoricidin
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $723
- Updated
- 2021/12/16
licoricidin Chemical Properties,Usage,Production
Definition
ChEBI: Licoricidin is a member of the class of hydroxyisoflavans that is R-isoflavan with hydroxy groups at positions 7, 2' and 4', a methoxy group at position 5 and prenyl groups at positions 6 and 3'. Isolated from Glycyrrhiza uralensis, it exhibits antibacterial activity. It has a role as an antibacterial agent and a plant metabolite. It is a member of hydroxyisoflavans, an aromatic ether and a methoxyisoflavan.
Biological Activity
Licoricidin (LCD), isolated from Glycyrrhiza uralensis Fisch, has anticancer activity. It (LCD) can be used in the study of colorectal cancer by inducing cycle arrest, apoptosis and autophagy. Licoricidin (LCD) inhibits lung metastasis by inhibiting tumor angiogenesis and lymphangiogenesis and changes in the local microenvironment of tumor tissue. Licoricidin (LCD) enhances gemcitabine-induced cytotoxicity of osteosarcoma (OS) cells through inactivation of Akt and NF-κB pathways in vitro and in vivo.
in vitro
Licoricidin (LCD) (0-20 μM; 24 hours) dose-dependently inhibits the viability of colon cancer cell lines with various pathological and genetic characters, namely SW480, HCT116, SW620 and LoVo cells, with IC < sub> 50 values of 7.2, 5.4, 4.5 and 5.1 μM, respectively. Licoricidin (LCD) (0-20 μM; 0-12 hours) induces cell apoptosis was accompanied with the activation of caspase-3 by cleavage in a time- and dose-dependent manner. Licoricidin (LCD) (0-20 μM; 0-12 hours) induces autophagy of SW480 cells, increases the cleavage of LC3-I to LC3-II and the degradation of p62 in a time and Dose dependent manner. Licoricidin (LCD) (0-5 μg/ml; 18 hours) inhibits cell migration, MMP-9 secretion, and VCAM expression in 4T1 cells.
< /p>
Cell Viability Assay
| Cell Line: | SW480, HCT116, SW620 and LoVo cells | Concentration: | 0-20 μM |
| Incubation Time: | 24 hours |
| Result: | Decreased colon cancer cell lines viability. |
Western Blot Analysis < /p>
| Cell Line: | SW480 cells |
| Concentration: | 0 μM, 2.5 μM, 5 μM, 10 μM, 20 μM |
| Incubation Time: | 0 hours, 1 hour, 3 hours, 6 hours, 12 hours |
| Result: | Induced cell apoptosis. |
in vivo
Licoricidin (LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 15 days) significantly inhibited the growth of SW480 xenografts in nude mice with an inhibitory rate of 43.5%. Licoricidin ( LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days) reduces pulmonary metastasis and the expression of CD45, CD31, HIF-1α, iNOS, COX-2, and VEGF-A in tumor tissues , additionally, decreased protein expression of VEGF-R2, VEGF-C, VEGF-R3, and LYVE-1 in tumor tissues of licoricidin-treated mice.
| Animal Model: | SW480 xenografted tumor growth in nude mice |
| Dosage: | 5, 10, or 20 mg/kg |
| Administration: | Intraperitoneal injection; once daily; 15 days |
| Result: | Decreased tumor volumes. |
| Animal Model: | BALB/c mouse orthotopic model |
| Dosage: | 5, 10, or 20 mg/kg |
| Administration: | Intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days |
| Result: | Inhibited Lung Metastasis of 4T1 Murine Mammary Carcinoma cells. |
licoricidin Preparation Products And Raw materials
Raw materials
Preparation Products
licoricidin Suppliers
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5653
- Advantage
- 65
- Tel
- 400-400-186-5138 13341702378
- Fax
- QQ：190129269
- winherb@126.com
- Country
- China
- ProdList
- 1007
- Advantage
- 58
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7887
- Advantage
- 56
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 18607101326 15172504745
- Fax
- +86-27-84254680
- aileen@chemfaces.com
- Country
- China
- ProdList
- 7057
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27313
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 021-36031160 13311776681
- 3338195766@QQ.com
- Country
- China
- ProdList
- 5175
- Advantage
- 55
- Tel
- 021-69955236-807 13918189704
- Fax
- 021-65211385
- chinaruji@chinaruji.com
- Country
- China
- ProdList
- 5176
- Advantage
- 55
- Tel
- 028-85370565-229 18080489829
- 3004654993@qq.com
- Country
- China
- ProdList
- 8907
- Advantage
- 60
- Tel
- 010-010-010-62971590 18548936886
- Fax
- 010-62340519
- jack@oka-vip.com
- Country
- China
- ProdList
- 6897
- Advantage
- 58
- Tel
- 025-025-51191215 18013836722
- Fax
- 025-51191215
- 2399235533@qq.com
- Country
- China
- ProdList
- 4933
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- 18871490254
- Fax
- 027-59599243
- linda@hubeijusheng.com
- Country
- CHINA
- ProdList
- 28172
- Advantage
- 58
- Tel
- 028-028-85142057 19983342022
- Fax
- 028-85142057
- 3005359975@qq.com
- Country
- China
- ProdList
- 1950
- Advantage
- 58
- Tel
- 021-54721350 13524668266
- Fax
- 021-5
- 2881505714@qq.com
- Country
- China
- ProdList
- 7872
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- wulan@absin.cn
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 021-57763112 13585886131
- 3004987436@qq.com
- Country
- China
- ProdList
- 9693
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14081
- Advantage
- 58
- Tel
- 021-57886085 17317861055
- shhebio@126.com
- Country
- CHINA
- ProdList
- 7974
- Advantage
- 58
- Tel
- 027-59223108 15972152991
- Fax
- 027-59223108
- 1248580099@qq.com
- Country
- China
- ProdList
- 9988
- Advantage
- 58
- Tel
- 027-59223025 15107168801
- Fax
- 027-59223025
- 1718480011@qq.com
- Country
- China
- ProdList
- 9865
- Advantage
- 58
- Tel
- 0757-85921206 18520245316
- 2329783215@qq.com
- Country
- China
- ProdList
- 12661
- Advantage
- 58
- Tel
- 18661161657
- yaoxiangqiu2021@163.com
- Country
- China
- ProdList
- 9996
- Advantage
- 58
- Tel
- 18080489829
- 3004654993@qq.com
- Country
- China
- ProdList
- 9209
- Advantage
- 58
- Tel
- 021-38218169 13341702378
- 190129269@qq.com
- Country
- China
- ProdList
- 9126
- Advantage
- 58
- Tel
- 0512-65118909 15162312715
- sales@szzxbio.com
- Country
- China
- ProdList
- 2990
- Advantage
- 58
- Tel
- 021-69985186 13611928337
- 3427709316@qq.com
- Country
- China
- ProdList
- 7979
- Advantage
- 58
- Tel
- 4001-009266 17349750668
- product@sci-e.com
- Country
- China
- ProdList
- 2808
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- rose.shi@synzest.com
- Country
- China
- ProdList
- 6210
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9272
- Advantage
- 58
- Tel
- 18162791556
- 3152548389@qq.com
- Country
- China
- ProdList
- 4351
- Advantage
- 58
- Tel
- 18672534757
- xiaoxue.hu@fuorain.cn
- Country
- China
- ProdList
- 1850
- Advantage
- 58
- Tel
- 28-86-28-8543-3893 13260669172
- sales@biocrick.com
- Country
- China
- ProdList
- 5020
- Advantage
- 58
- Tel
- 029-86107037 13289246953
- info@konochemical.com
- Country
- China
- ProdList
- 2993
- Advantage
- 58
- Tel
- 18017610038
- zheyansh@163.com
- Country
- CHINA
- ProdList
- 3619
- Advantage
- 58
- Tel
- +8613817748580
- Fax
- 021-50175322
- cooperation@kean-chem.com
- Country
- China
- ProdList
- 40066
- Advantage
- 58
- Tel
- +undefined18621343501
- product@acmec-e.com
- Country
- China
- ProdList
- 33338
- Advantage
- 58
- Tel
- +86-0371-63689365 +8618638391208
- sales@aochuangchem.com
- Country
- China
- ProdList
- 9237
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@mail.biobiopha.com
- Country
- CHINA
- ProdList
- 6463
- Advantage
- 58
- Tel
- --
- Fax
- --
- 2090855807@qq.com
- Country
- CHINA
- ProdList
- 6063
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- 3245176082@qq.com
- Country
- CHINA
- ProdList
- 6134
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6333
- Advantage
- 58
- Tel
- --
- Fax
- --
- shhebio@126.com
- Country
- CHINA
- ProdList
- 6137
- Advantage
- 58
- Tel
- --
- Fax
- --
- shxiyuanbio@163.com
- Country
- CHINA
- ProdList
- 6906
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1562893815@qq.com
- Country
- CHINA
- ProdList
- 6936
- Advantage
- 58
- Tel
- --
- Fax
- --
- yiji01@foxmail.com
- Country
- China
- ProdList
- 6289
- Advantage
- 50
- Tel
- --
- Fax
- --
- 2836767067@qq.com
- Country
- CHINA
- ProdList
- 6970
- Advantage
- 58