ChemicalBook > CAS DataBase List > 2,2,2-Trifluoroethyl trifluoromethanesulfonate

2,2,2-Trifluoroethyl trifluoromethanesulfonate

Product Name
2,2,2-Trifluoroethyl trifluoromethanesulfonate
CAS No.
6226-25-1
Chemical Name
2,2,2-Trifluoroethyl trifluoromethanesulfonate
Synonyms
2,2,2-TRIFLUOROETHYL TRIFLUOROMETHANESULPHONATE;2,2,2-TRIFLUOROETHYL TRIFLATE;TFOL-TF;2,2,2-Trifluoroethyl Triflante;2,2,2-Trifluoroethyl trifluoromethanesulf;2-Trifluoroethyl trifluoromethanesulfonate;2,2,2-Trifluoroethytrifluoromethanesulfonate;2,2,2-Trifluoroethyl trifluoromethanesulfote;2,2,2-Trifluoroethyl trifluoroMethylsulfonate;2,2,2-TRIFLUOROETHYL TRIFLUOROMETHANESULFONATE
CBNumber
CB5142808
Molecular Formula
C3H2F6O3S
Formula Weight
232.1
MOL File
6226-25-1.mol
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2,2,2-Trifluoroethyl trifluoromethanesulfonate Property

Boiling point:
89-91°C
Density 
1,61 g/cm3
refractive index 
1.3037
RTECS 
PB2775000
Flash point:
>110°(230°F)
storage temp. 
2-8°C
solubility 
Chloroform, Methanol (Slightly)
form 
Liquid
color 
Colorless to yellow
Water Solubility 
Slightly soluble in water.
Sensitive 
Moisture Sensitive
InChI
InChI=1S/C3H2F6O3S/c4-2(5,6)1-12-13(10,11)3(7,8)9/h1H2
InChIKey
RTMMSCJWQYWMNK-UHFFFAOYSA-N
SMILES
C(F)(F)(F)S(OCC(F)(F)F)(=O)=O
CAS DataBase Reference
6226-25-1(CAS DataBase Reference)
EPA Substance Registry System
Methanesulfonic acid, trifluoro-, 2,2,2-trifluoroethyl ester (6226-25-1)
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Safety

Hazard Codes 
Xi,T,C
Risk Statements 
36/37/38-34-23/25
Safety Statements 
26-36/37/39-45
RIDADR 
3265
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
TOXIC, CORROSIVE
HazardClass 
8
PackingGroup 
Ⅱ
HS Code 
29055900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
752924
Product name
2,2,2-Trifluoroethyl trifluoromethanesulfonate
Purity
95%
Packaging
5g
Price
$132.05
Updated
2025/07/31
TCI Chemical
Product number
T1604
Product name
2,2,2-Trifluoroethyl Trifluoromethanesulfonate
Purity
>97.0%(GC)
Packaging
5g
Price
$142
Updated
2025/07/31
TCI Chemical
Product number
T1604
Product name
2,2,2-Trifluoroethyl Trifluoromethanesulfonate
Purity
>97.0%(GC)
Packaging
25g
Price
$354
Updated
2025/07/31
TRC
Product number
T790300
Product name
2,2,2-TrifluoroethylTriflate
Packaging
25g
Price
$275
Updated
2021/12/16
TRC
Product number
T790300
Product name
2,2,2-TrifluoroethylTriflate
Packaging
100g
Price
$545
Updated
2021/12/16
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2,2,2-Trifluoroethyl trifluoromethanesulfonate Chemical Properties,Usage,Production

Uses

A fluorine-containing alkyl alkanesulfonate with cyctotoxity towards cultured leukemia L1210 cells.

Uses

2,2,2-Trifluoroethyl trifluoromethanesulfonate is a powerful trifluoroethylating agent which is useful for synthesis of fluorinated amino acids. It is used as a reagent in thenantioselective preparation of cyclic N-aryl hydroxamic acids via phase-transfer catalyzed alkylation of nitrobenzyl bromides to give nirophenylalanines.

Uses

Reagent used in thenantioselective preparation of cyclic N-aryl hydroxamic acids via phase-transfer catalyzed alkylation of nitrobenzyl bromides to give nirophenylalanines

Synthesis

In a 100-ml flask equipped with a stirrer, a thermometer, a nitrogen introducing pipe, and a condenser, 50 ml (0.297 mol) of trifluoromethane sulfonic anhydride and 25 ml (0.342 moles) of 2,2,2-trifluoroethanol were placed at room temperature and stirred for 30 minutes in a nitrogen atmosphere, followed by reflux for 3 hours. After distillation, 50.3 g of 2,2,2-trifluoroethyl trifluoromethanesulfonate was obtained in a yield of 73%.

References

[1] Patent: US2014/249162, 2014, A1. Location in patent: Paragraph 0423; 0424; 0425
[2] Patent: EP2781519, 2014, A1. Location in patent: Paragraph 0404; 0405; 0406
[3] Tetrahedron, 1988, vol. 44, # 17, p. 5375 - 5387
[4] Journal of Organic Chemistry, 1984, vol. 49, # 12, p. 2258 - 2273
[5] Journal of Fluorine Chemistry, 2016, vol. 192, p. 131 - 140

2,2,2-Trifluoroethyl trifluoromethanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2,2-Trifluoroethyl trifluoromethanesulfonate Suppliers

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View Lastest Price from 2,2,2-Trifluoroethyl trifluoromethanesulfonate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2,2,2-Trifluoroethyl trifluoromethanesulfonate 6226-25-1
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-17
Shaanxi Dideu New Materials Co. Ltd
Product
2,2,2-Trifluoroethyl trifluoromethanesulfonate 6226-25-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-07-07
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2,2,2-Trifluoroethyl trifluoromethanesulfonate 6226-25-1
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-13

6226-25-1, 2,2,2-Trifluoroethyl trifluoromethanesulfonateRelated Search:

Trifluoromethanesulfonic acid DIBUTYLBORON TRIFLUOROMETHANESULFONATE YTTERBIUM(III) TRIFLUOROMETHANESULFONATE HYDRATE COPPER(II) TRIFLUOROMETHANESULFONATE BUPIRIMATE Lithium trifluoromethanesulfonate FLUOROSULFONIC ACID Sodium isethionate Sodium trifluoromethanesulfonate Levofloxacin Methylate Trifluoromethanesulfonic anhydride Pefloxacin mesylate Ethyl methanesulfonate Methanesulfonic acid Methyl trifluoromethanesulfonate Trimethylsilyl trifluoromethanesulfonate Ethyl trifluoromethanesulfonate HEXAFLUOROISOPROPYL TRIFLUOROMETHANESULFONATE

  • 2,2,2-trifluoroethyltrifluorometanesulfonicacid
  • methanesulfonicacid,trifluoro-,2,2,2-trifluoroethylester
  • TRIFLUOROMETHANESULFONIC ACID 2,2,2-TRIFLUOROETHYL ESTER
  • TFOL-TF
  • 2,2,2-TRIFLUOROETHYL TRIFLATE
  • 2,2,2-TRIFLUOROETHYL TRIFLUOROMETHANESULFONATE
  • 2,2,2-TRIFLUOROETHYL TRIFLUOROMETHANESULPHONATE
  • 2,2,2-Trifluoroethyltrifluoromethanesulphonate97%
  • TRIFLUOROMETHANESULPHONICACID2,2,2-TRIFLUOROETHYLESTER
  • 2,2,2 Trifluoroethyl TrifluoroMathane sulfonate
  • 2,2,2-Trifluoroethyl trifluoromethanesulphonate 97%
  • 2,2,2-Trifluoroethanol TrifluoroMethanesulfonate
  • 2,2,2-Trifluoroethyl trifluoroMethylsulfonate
  • 2,2,2-Trifluoroethyl Triflate Trifluoromethanesulfonic Acid 2,2,2-Trifluoroethyl Ester
  • Trifluoromethane sulfonate trifluoroethyl ester
  • 2,2,2-Trifluoroethytrifluoromethanesulfonate
  • 2,2,2-Trifluoroethyl trifluoromethanesulfote
  • 2-Trifluoroethyl trifluoromethanesulfonate
  • 1,1,1-Trifluoro-2,2,2-trifluoroethyl Ester Methanesulfonic Acid
  • Methanesulfonic acid, 1,1,1-trifluoro-, 2,2,2-trifluoroethyl ester
  • High purity CAS 6226-25-1 2,2,2-Trifluoroethyl trifluoromethanesulfonate in stock
  • 2,2,2-TRIFLUOROETHYL TRIFLATE 2,2,2-Trifluoroethyl Trifluoromethanesulfonate
  • 2,2,2-Trifluoroethyl Triflante
  • 2,2,2-Trifluoroethyl trifluoromethanesulf
  • 6226-25-1
  • 56226-25-1
  • C3H2F6O3S
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