3-isobutylglutaric acid

Product Name: 3-isobutylglutaric acid
CAS No.: 75143-89-4
Chemical Name: 3-isobutylglutaric acid
Synonyms: Pregabalin IMpurity I;Pregabalin Diacid-Imp;3-Isobutylglutaricaci;Isobutyl Glutaric Acid;3-isobutylglutaric acid;Pregabalin Impurity B(EP);3-ISOBUTYLPENTANEDIOC ACID;Pregabalin Impurity (IBGA);3-Isobutylpentanedioic acid;3-Isobutylglutaric acid 99%
CBNumber: CB51458214
Molecular Formula: C9H16O4
Formula Weight: 188.22
MOL File: 75143-89-4.mol

More

Less

3-isobutylglutaric acid Property

Melting point:: 47 °C
Boiling point:: 326.2±15.0 °C(Predicted)
Density: 1.126±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
pka: 4.19±0.10(Predicted)
color: White to Pale Brown
Major Application: pharmaceutical small molecule
InChI: InChI=1S/C9H16O4/c1-6(2)3-7(4-8(10)11)5-9(12)13/h6-7H,3-5H2,1-2H3,(H,10,11)(H,12,13)
InChIKey: UATSLDZQNXAKMA-UHFFFAOYSA-N
SMILES: C(O)(=O)CC(CC(C)C)CC(O)=O

More

Less

Safety

HS Code: 2917198090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

More

Less

N-Bromosuccinimide Price

TRC

Product number: M326335
Product name: 3-(2-Methylpropyl)pentanedioicAcid
Packaging: 5g
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: J50695
Product name: 3-Isobutylglutaricacid
Packaging: 25g
Price: $20
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2121-1-46
Product name: 3-Isobutylglutaric acid
Packaging: 25g
Price: $21
Updated: 2021/12/16

AK Scientific

Product number: 1684AC
Product name: 3-Isobutylglutaricacid
Packaging: 25g
Price: $27
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2121-1-46
Product name: 3-Isobutylglutaric acid
Packaging: 100g
Price: $52
Updated: 2021/12/16

More

Less

3-isobutylglutaric acid Chemical Properties,Usage,Production

Chemical Properties

Pale Brown Solid

Uses

An impurity of Pregabalin (P704800) with anticonvulsant properties.

Application

3-Butylglutaric acid is an intermediate in the synthesis of pregabalin.Pregabalin is approved by the United States Food and Drug Administration (FDA) to treat neuropathic pain associated with diabetic peripheral neuropathy, spinal cord injury, and postherpetic neuralgia. Pregabalin is FDA-approved for the treatment of fibromyalgia. Pregabalin also has FDA approval as adjunctive therapy for partial-onset seizures in adults with epilepsy.

Synthesis

3-isobutylglutaric acid, a potential impurity which is base hydrolyzed product during Hofmann reaction, was synthesized by the reaction of (R)-(-)-3-carbamoylmethyl-5-methylhexanoic acid with excess of sodium hydroxide at elevated temperature^[1].

References

[1] Sripathi, S., Somesetti, N. R., Veeramalla, R., Challa, N. R., Peddi, S., Karnati, V. R. (2010). Synthesis and characterization of impurities of an anticonvulsant drug, Pregabalin. Arkivoc, 2010 1. https://doi.org/10.3998/ARK.5550190.0011.A22

3-isobutylglutaric acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-isobutylglutaric acid Suppliers

Canada 1 China 266 India 20 United Kingdom 2 United States 10 Global 299

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 0371-0371-13526885213 15637198702
Fax: 0371-63709726
Email: hsyykjchem@163.com
Country: China
ProdList: 3910
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44802
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 15618770481
Fax: 021-64823266
Email: yhx@titansci.com
Country: China
ProdList: 14100
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13770331960
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16059
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527621225; 15527621225
Email: 1791901229@qq.com
Country: China
ProdList: 6870
Advantage: 52

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7440
Advantage: 65

More

Less

View Lastest Price from 3-isobutylglutaric acid manufacturers

Chongqing Soarwin Technology Co., Ltd

Product: 3-isobutylglutaric acid 75143-89-4
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2025-04-11

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 3-isobutylglutaric acid 75143-89-4
Price: US $990.00-800.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-19

Henan Aochuang Chemical Co.,Ltd.

Product: 3-isobutylglutaric acid 75143-89-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-13

75143-89-4, 3-isobutylglutaric acidRelated Search:

Hexanoic acid,3-(aminomethyl)-5-methyl-, (3R)- Pregabalin Impurity 4 5,6-Dehydropregabalin Glutaric acid 4-(NAPHTHALEN-1-YL)PHENYLBORONIC ACID 3-Isomangostin hydrate 3-Isomangostin hydrate formate Tetramethyl glutaric aciduria Pregabalin Impurity 28 PD 312236 4-Isobutyl-2-pyrrolidinone Pregabalin Impurity 49 Pregabalin Impurity PD0224377 Isovaleraldehyde 4,9-diisobutyl-1,6-diazecane-2,7-dione 3-((methoxycarbonyl)methyl)-5-methylhexanoic acid 2,4-Dicyano-3-(2-Methylpropyl)-pentanediaMide Pregabalin Impurity D: Pregabalin-2-ene

3-isobutylglutaric acid

3-(2-Methylpropyl)pentanedioic Acid

3-Isobutylglutaric acid 99%

Pentanedioic acid,3-(2-Methylpropyl)-

Pregabalin IMpurity I

3-Isobutylpentanedioic acid

3-Isobutylglutaric acid(99%)

Pregabalin Impurity B(3-IsoButylglutaricAcid)

Isobutyl Glutaric Acid

Pregabalin Diacid-Imp

Pregabalin Isobutylglutaric acid

3-ISOBUTYLPENTANEDIOC ACID

Pregabalin 3-Carboxymethyl Impurity

Isobutyl glutaric Acid(Pregablin)

Pregabalin Diacid Impurity (Pregabalin 3-Carboxy Impurity)

Factory supply 3-Isobutylglutaric Acid CAS 75143-89-4 high quality

Pregabalin Impurity BQ: What is Pregabalin Impurity B Q: What is the CAS Number of Pregabalin Impurity B Q: What is the storage condition of Pregabalin Impurity B Q: What are the applications of Pregabalin Impurity B

Pregabalin Impurity B(EP)

3-(2-Methylpropyl)pentanedioic Acid (3-Isobutylglutaric Acid)

Pregabalin Impurity 2(3-Isobutylglutaric Acid)

Pregabalin Impurity 80 (3-Isobutylglutaric Acid)

3-Isobutylglutaric acid or CMH Diacid

Pregabalin Impurity (IBGA)

Pregabalin Impurity 4/Pregabalin Impurity B (3-Isobutylglutaric Acid)

3-Isobutylglutaricaci

75143-89-4

Aliphatics

Impurities

Intermediates & Fine Chemicals

Pharmaceuticals

intermidiate of Pregablin

bc0001