Broussonin A
- Product Name
- Broussonin A
- CAS No.
- 73731-87-0
- Chemical Name
- Broussonin A
- Synonyms
- Broussonin A;2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol;Phenol, 2-[3-(4-hydroxyphenyl)propyl]-5-methoxy-
- CBNumber
- CB51469522
- Molecular Formula
- C16H18O3
- Formula Weight
- 258.31
- MOL File
- 73731-87-0.mol
Broussonin A Property
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
N-Bromosuccinimide Price
- Product number
- CFN97694
- Product name
- BroussoninA
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $513
- Updated
- 2021/12/16
- Product number
- CD32000511
- Product name
- BroussoninA
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $810
- Updated
- 2021/12/16
Broussonin A Chemical Properties,Usage,Production
Description
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A and nyasol suppress lipopolysaccharide (LPS)-stimulated inducible nitric oxide synthase (iNOS) expression at the transcriptional level through modulating NF-κB and down-regulation of the Akt and ERK signaling pathways. 3. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. 4. Broussonin A can significantly inhibit adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay.
Uses
Broussonin A is a potent BChE inhibitor, with an IC50 of 4.16 μM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation[1][2][3].
target
NOS | Akt | ERK | Estrogen receptor | IFN-γ | IL Receptor | NF-kB | IkB | IKK | Progestogen receptor
IC 50
BChE: 4.16 μM (IC50)
References
[1] Kim JH, et al. Broussonin A- and B-mediated inhibition of angiogenesis by blockade of VEGFR-2 signalling pathways and integrin β1 expression. J Cell Mol Med. 2022 Feb;26(4):1194-1205. DOI:10.1111/jcmm.17173
[2] Lee JP, et al. Potent inhibition of acetylcholinesterase by sargachromanol I from Sargassum siliquastrum and by selected natural compounds. Bioorg Chem. 2019 Aug;89:103043. DOI:10.1016/j.bioorg.2019.103043
[3] Chang C F, et al. Bioactive compounds from the bark of Broussonetia papyrifera after solid fermentation with a white rot fungus Perenniporia tephropora[J]. Journal of Wood Chemistry and Technology, 2020:1-14.
Broussonin A Preparation Products And Raw materials
Raw materials
Preparation Products
Broussonin A Suppliers
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