5-BROMOINDOLINE

Product Name: 5-BROMOINDOLINE
CAS No.: 22190-33-6
Chemical Name: 5-BROMOINDOLINE
Synonyms: AKOS BC-0891;5-BROMOINDOLINE;5-Bromoindoline >5-Bromoindoline 97%;5-Bromoindoline,97%;5-bromodihydroindole;5-Bromoindoline,98+%;Zopiclone Impurity 34;5-BroMo-2,3-dihydroindole;5-BROMO-2,3-DIHYDRO-1H-INDOLE
CBNumber: CB5149584
Molecular Formula: C8H8BrN
Formula Weight: 198.06
MOL File: 22190-33-6.mol

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5-BROMOINDOLINE Property

Melting point:: 36-40 °C (lit.)
Boiling point:: 114-115°C 5mm
Density: 1.5240 g/cm3
refractive index: 1.63
Flash point:: >230 °F
storage temp.: -20°C
solubility: DMSO, Methanol
form: Solid
pka: 4.35±0.20(Predicted)
color: Off-White
BRN: 121590
InChI: InChI=1S/C8H8BrN/c9-7-1-2-8-6(5-7)3-4-10-8/h1-2,5,10H,3-4H2
InChIKey: QEDCHCLHHGGYBT-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(Br)C=C2)CC1
CAS DataBase Reference: 22190-33-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
PackingGroup: III
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 642371
Product name: 5-Bromoindoline
Purity: 97%
Packaging: 5g
Price: $90.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 642371
Product name: 5-Bromoindoline
Purity: 97%
Packaging: 1g
Price: $51.6
Updated: 2023/01/07

TCI Chemical

Product number: B3885
Product name: 5-Bromoindoline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: B3885
Product name: 5-Bromoindoline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $70
Updated: 2025/07/31

TRC

Product number: B684610
Product name: 5-Bromoindoline
Packaging: 50g
Price: $990
Updated: 2021/12/16

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5-BROMOINDOLINE Chemical Properties,Usage,Production

Chemical Properties

White to brown low melting solid

Uses

5-Bromoindoline is a brominated indoline derivative and a product of biocatalyzed halogenation of nucleobase analogs. 5-Bromoindoline is used in the synthetic preparation of biologically active compou nds such as selective human β3 adrenergic receptor agonists.

Synthesis

22190-38-1

22190-33-6

A) 38 g (0.16 mol) of 1-acetyl-5-bromoindoline, 31 g of concentrated hydrochloric acid and 41 g of ethanol were added to the reaction flask and stirred thoroughly to obtain reaction mixture I; B) reaction mixture I was reacted at 78 °C for 4 h. Complete disappearance of the raw materials was confirmed by chromatographic monitoring; C) the reaction mixture was neutralized using 55 g of sodium hydroxide solution; D) the organic phase J and the aqueous phase K were separated; E) the organic phase J was extracted three times using 445 g of chloroform. K; E) Organic phase J was extracted three times with 445 g of chloroform. The organic layers were combined and the solvent was recovered to give 30.74 g of 5-bromodihydroindole in 98.04% yield and ≥99% purity.

References

[1] Patent: CN106432040, 2017, A. Location in patent: Paragraph 0108-0113; 0135-0140; 0162-0167
[2] European Journal of Medicinal Chemistry, 2006, vol. 41, # 1, p. 88 - 100
[3] Tetrahedron Letters, 2004, vol. 45, # 25, p. 4827 - 4830
[4] Patent: CN106966950, 2017, A. Location in patent: Paragraph 0022
[5] Patent: US2011/98311, 2011, A1

5-BROMOINDOLINE Preparation Products And Raw materials

Raw materials

Acetic anhydride Cyclohexane Acetyl chloride Sodium Triethylamine Indoline Sodium bisulfite Tetrahydrofuran Ethyl acetate Hydrochloric acid Bromine Dichloromethane Acetic acid Methanol Sodium hydroxide Magnesium sulfate

Preparation Products

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5-BROMOINDOLINE Suppliers

Americas 1 Canada 1 China 211 Europe 3 Germany 5 India 20 Japan 1 Switzerland 1 Ukraine 2 United Kingdom 14 United States 30 Global 289

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View Lastest Price from 5-BROMOINDOLINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-BROMOINDOLINE 22190-33-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-BROMOINDOLINE 22190-33-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Chemwill Asia Co.,Ltd.

Product: 5-Bromoindoline 5-Bromo-2,3-dihydro-1H-indole in stock Factory 22190-33-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: TOP 3 Factory in China
Supply Ability: Top 3 production capacity Factory
Release date: 2019-04-03

22190-33-6, 5-BROMOINDOLINERelated Search:

5-Bromoisoquinoline 5-BroMo-2,3-dihydro-1H-indolehydrochloride 5-Bromo-2-oxindole 5-Bromoindazole 5-BROMOINDOLE-3-ACETIC ACID 5-Bromoindole-3-acetonitrile 5-Bromoindole-3-carboxaldehyde 1-Piperazinecarboxylicacid,4-methyl-,ethylester(6CI,9CI) 8-METHYLXANTHINE N-(5-Chloro-2-pyridinyl)-2-pyrazinecarboxaMide (Zopiclone IMpurity) Benzyl (3S,4R)-3-ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxylate N-(5-Chloro-2-pyridinyl)-3-(hydroxyMethyl)-2-pyrazinecarboxaMide 8-PHENYLTHEOPHYLLINE 3-(5-CHLOROPYRID-2-YL)CARBAMOYLPYRAZINE-2-CARBOXYLIC ACID(WXG01564) Substituted pyrazine 2-Acetamido-5-chloropyridine CHEMBRDG-BB 7613529 6-(5-Chloro-2-pyridyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione

5-BROMOINDOLINE

AKOS BC-0891

5-BROMO-2,3-DIHYDRO-1H-INDOLE

5-Bromoindoline,98+%

5-Bromoindoline,97%

5-bromodihydroindole

1H-Indole, 5-broMo-2,3-dihydro-

5-BroMo-2,3-dihydroindole

5-Bromoindoline 5-Bromo-2,3-dihydro-1H-indole in stock Factory

5-Bromoindoline 97%

5-Bromoindoline &gt

Zopiclone Impurity 34

22190-33-6

22190-33-67

C8H8BrN

Halogenated Heterocycles

Heterocyclic Building Blocks

Indolines

Building Blocks

Heterocycle-Indole series

Indoles and derivatives

Indoline & Oxindole

Halogenated Heterocycles

Heterocyclic Building Blocks

Indolines

IndolinesBuilding Blocks