ISOTHIAZOLINE 1,1-DIOXIDE
- Product Name
- ISOTHIAZOLINE 1,1-DIOXIDE
- CAS No.
- 5908-62-3
- Chemical Name
- ISOTHIAZOLINE 1,1-DIOXIDE
- Synonyms
- IsothiazoL;idine 1,1-dioxide;ISOTHIAZOLINE 1,1-DIOXIDE;1,2-thiazolidine-1,1-dione;1,2-thiazolidine 1,1-dioxide;ISOTHIAZOLINE 1,1-DIOXIDE, 10 mM in DMSO;ISOTHIAZOLINE 1,1 DIOXIDE,ISOTHIAZOLINE 1,1DIOXIDE
- CBNumber
- CB51502322
- Molecular Formula
- C3H7NO2S
- Formula Weight
- 121.16
- MOL File
- 5908-62-3.mol
ISOTHIAZOLINE 1,1-DIOXIDE Property
- Melting point:
- 145-146 °C
- Boiling point:
- 128-132 °C(Press: 0.18 Torr)
- Density
- 1.326±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 11.52±0.20(Predicted)
- form
- liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C3H7NO2S/c5-7(6)3-1-2-4-7/h4H,1-3H2
- InChIKey
- XGYCWCIGCYGQFU-UHFFFAOYSA-N
- SMILES
- S1(=O)(=O)CCCN1
Safety
- WGK Germany
- 3
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P835288
- Product name
- PropaneSultam
- Packaging
- 100mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- CHM0073370
- Product name
- 1,1-DIOXO-ISOTHIAZOLIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $736.12
- Updated
- 2021/12/16
- Product number
- CHM0073370
- Product name
- 1,1-DIOXO-ISOTHIAZOLIDINE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1011.6
- Updated
- 2021/12/16
- Product number
- CHM0073370
- Product name
- 1,1-DIOXO-ISOTHIAZOLIDINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1210.63
- Updated
- 2021/12/16
- Product number
- CS-W001194
- Product name
- 1,1-Dioxoisothiazolidine
- Purity
- ≥98.0%
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
ISOTHIAZOLINE 1,1-DIOXIDE Chemical Properties,Usage,Production
Uses
Propane Sultam is a reactant used in the synthesis of orally bioavailable hebatits B caspid inhibitors as well as in the preparation of cryptochrome imhibitors as antidiabetic agents.
Synthesis
35578-28-0
5908-62-3
At room temperature, 3-chloropropane-1-sulfonamide (27 g, 170 mmol, 1 eq.) was dissolved in ethanol (250 ml), followed by addition of sodium ethoxide (11.7 g, 170 mmol, 1 eq.). The reaction mixture was heated to reflux for 5 h. After completion of the reaction it was cooled to room temperature and concentrated under reduced pressure. The residual solid was fully extracted with dichloromethane, the organic phases were combined and concentrated under reduced pressure to give 1,1-dioxoisothiazolidine (20 g, 100% yield).
References
[1] Patent: WO2004/50619, 2004, A1. Location in patent: Page 24
[2] Journal of the American Chemical Society, 2015, vol. 137, # 17, p. 5638 - 5641
[3] Journal of Organic Chemistry, 1987, vol. 52, # 11, p. 2162 - 2166
[4] Patent: WO2012/3283, 2012, A1. Location in patent: Page/Page column 206-207
[5] Patent: US2012/316147, 2012, A1. Location in patent: Page/Page column 62-63
ISOTHIAZOLINE 1,1-DIOXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ISOTHIAZOLINE 1,1-DIOXIDE Suppliers
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- Ukraine
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View Lastest Price from ISOTHIAZOLINE 1,1-DIOXIDE manufacturers
- Product
- 1,3-Propanesultam 5908-62-3
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19