2-PHENYLETHANIMIDAMIDE HYDROCHLORIDE
- Product Name
- 2-PHENYLETHANIMIDAMIDE HYDROCHLORIDE
- CAS No.
- 2498-46-6
- Chemical Name
- 2-PHENYLETHANIMIDAMIDE HYDROCHLORIDE
- Synonyms
- 2-PhenylacetiMidaMide hydrochloride;2-phenylacetamidine hydrochloride;2-PHENYLETHANIMIDAMIDE HYDROCHLORIDE;1-amino-2-phenylethaniminium chloride;2-Phenylethanimidamide hydrochloride (1:1);Benzeneethanimidamide, hydrochloride (1:1)
- CBNumber
- CB51517032
- Molecular Formula
- C8H10N2.HCl
- Formula Weight
- 0
- MOL File
- 2498-46-6.mol
2-PHENYLETHANIMIDAMIDE HYDROCHLORIDE Property
- Melting point:
- 145-147 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P335588
- Product name
- 2-PhenylacetimidamideHydrochloride
- Packaging
- 1g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- 6808CT
- Product name
- 2-Phenylethanimidamidehydrochloride
- Packaging
- 250mg
- Price
- $138
- Updated
- 2021/12/16
- Product number
- CHM0097714
- Product name
- 2-PHENYLETHANIMIDAMIDE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $721.57
- Updated
- 2021/12/16
- Product number
- CHM0097714
- Product name
- 2-PHENYLETHANIMIDAMIDE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $983.88
- Updated
- 2021/12/16
- Product number
- CHM0097714
- Product name
- 2-PHENYLETHANIMIDAMIDE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1168.42
- Updated
- 2021/12/16
2-PHENYLETHANIMIDAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
2-Phenylacetimidamide Hydrochloride is useful for the preparation of trifluoromethyl pyrimido[1,3]diazepine compounds.
Synthesis
140-29-4
2498-46-6
The general procedure for the synthesis of 2-phenylacetamidine hydrochloride from phenylacetonitrile is as follows: ammonium chloride (2.9 g, 54 mmol) was suspended in 20 mL of anhydrous toluene, stirred under argon protection and cooled to 0 °C. To this suspension 25 mL (50 mmol) of 2 M trimethylaluminum in toluene was slowly added. After the reaction system was gradually warmed to room temperature, stirring was continued until the release of methane gas ceased (about 1 hour). Subsequently, 3.46 mL (30 mmol) of benzeneacetonitrile dissolved in 10 mL of anhydrous toluene was added and the reaction mixture was heated to 80°C and maintained for 18 hours. After completion of the reaction, it was cooled to room temperature and slowly poured into a slurry consisting of 15 g of silica gel with 50 mL of chloroform and stirred for 5 minutes. The silica gel was removed by filtration and washed with methanol. The filtrate was combined with the wash solution, concentrated to about 15 mL and filtered again. To the filtrate was added 18 mL (54 mmol) of 3 N methanolic hydrochloric acid solution followed by 400 mL of diethyl ether. After stirring for 16 hours at room temperature, the resulting white precipitate was collected by filtration. The crude product was dissolved in 150 mL of a solvent mixture of isopropanol and acetone (4:1, v/v) and stirred for 16 hours at room temperature. Undissolved ammonium chloride was removed by filtration and the filtrate was concentrated to about 15 mL. 300 mL of diethyl ether was added and stirred for 1 h. The white precipitate was obtained by filtration and 3.7 g (72% yield) of 2-benzeneethanimidamide hydrochloride was obtained after drying. Mass spectrum (ESI, positive ion mode) m/z: 157.9 (M+23). 1H NMR (500 MHz, DMSO-d6) δ (ppm): 9.06 (broad peak, 3H), 7.49 (double peak, 2H), 7.36 (triple peak, 2H), 7.31 (triple peak, 1H), 3.74 (single peak, 2H).
References
[1] Patent: US2009/286815, 2009, A1. Location in patent: Page/Page column 6-7
[2] Patent: US2009/286810, 2009, A1. Location in patent: Page/Page column 6
[3] Tetrahedron, 1984, vol. 40, # 5, p. 887 - 892
[4] Patent: US2008/146625, 2008, A1. Location in patent: Page/Page column 18
2-PHENYLETHANIMIDAMIDE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-PHENYLETHANIMIDAMIDE HYDROCHLORIDE manufacturers
- Product
- 2-PHENYLETHANIMIDAMIDE HYDROCHLORIDE 2498-46-6
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 5kg; 10kg
- Release date
- 2020-10-28