L-Homocystine

Product Name: L-Homocystine
CAS No.: 626-72-2
Chemical Name: L-Homocystine
Synonyms: (2S,2'S)-4,4'-Disulfanediylbis(2-aMinobutanoic acid);H-HoCys-OH;(H-HCY-OH)2;(H-Hcy-OH)?;H-L-HCystine;(H-HOCYS-OH)2;H-L-HOCYSTINE;(H-Hcys-OH) 2;L-Homocystine;(H-HOMOCYS-OH)2
CBNumber: CB5155903
Molecular Formula: C8H16N2O4S2
Formula Weight: 268.35
MOL File: 626-72-2.mol

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L-Homocystine Property

Melting point:: 281-284 °C (dec.)(lit.)
alpha: 77 º (c=1% in 1N HCl)
Boiling point:: 507.6±50.0 °C(Predicted)
Density: 1.443±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: H2O : 5 mg/mL (18.63 mM; ultrasonic and adjust pH to 3 with H2O)DMSO : 1 mg/mL (3.73 mM; ultrasonic and adjust pH to 5 with HCl)
form: Powder
pka: 1.90±0.10(Predicted)
color: Off-white to light yellow
optical activity: 73.7°(C=0.97g/100ml 1N HCL)
BRN: 1728583
InChI: InChI=1S/C8H16N2O4S2/c9-5(7(11)12)1-3-15-16-4-2-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)/t5-,6-/m0/s1
InChIKey: ZTVZLYBCZNMWCF-WDSKDSINSA-N
SMILES: S(CC[C@H](N)C(O)=O)SCC[C@H](N)C(O)=O
CAS DataBase Reference: 626-72-2(CAS DataBase Reference)
EPA Substance Registry System: L-Homocystine (626-72-2)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H6010
Product name: L-Homocystine
Purity: ≥98% (HPLC)
Packaging: 100mg
Price: $129
Updated: 2025/07/31

Sigma-Aldrich

Product number: H6010
Product name: L-Homocystine
Purity: ≥98% (HPLC)
Packaging: 1g
Price: $583.77
Updated: 2025/07/31

Sigma-Aldrich

Product number: H6010
Product name: L-Homocystine
Purity: ≥98% (HPLC)
Packaging: 500mg
Price: $371
Updated: 2025/07/31

TRC

Product number: H591360
Product name: L-Homocystine
Packaging: 10g
Price: $145
Updated: 2021/12/16

Usbiological

Product number: H7000
Product name: L-Homocystine, 99%
Packaging: 1g
Price: $330
Updated: 2021/12/16

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L-Homocystine Chemical Properties,Usage,Production

Chemical Properties

L-homocysteine is an aliphatic amino acid with the molecular formula (C8H16N2O4S2). It is a white powder with an acidic taste and is easily soluble in water. It has limited solubility in ethanol. L-homocysteine has a sulfhydryl group on its side chain, which allows it to form disulfide bonds with other L-homocysteine residues in proteins. This feature contributes to the stable three-dimensional structure of proteins. As a result, L-homocysteine finds extensive applications in industries such as pharmaceuticals, food, feed, and cosmetics.

Uses

Increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.

Definition

ChEBI: L,L-homocystine is a homocystine in which both chiral centres have L configuration. It is functionally related to a L-homocysteine. It is a tautomer of a L,L-homocystine zwitterion.

Biological Activity

L-Homocystine is the oxidized member of the L-homocysteine:L-homocystine pair. Homocysteine/homocystine is derived from methionine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.

Synthesis

L-homoserine(626-72-2) is biosynthesized from L-aspartate, which is synthesized from oxaloacetate, a TCA cycle intermediate. Homoserine is activated through esterification to form the O-acetyl ester by the enzyme homoserine O-acetyltransferase. In certain organisms, including the yeast Saccharomyces cerevisiae and certain bacteria, hydrogen sulfide reacts with O-acetyl-L-homoserine, replacing the acetyl group and forming L-homocysteine.

Purification Methods

The acid (3g) is dissolved in freshly boiled H2O (30mL) under N2, cooled under N2 (all operations should be under N2), absolute EtOH (100mL) is added, the acid is filtered off, and a second crop is obtained by diluting the filtrate to 500mL with absolute EtOH, kept overnight in a refrigerator, filtered, washed with EtOH and dried in a vacuum. The D(R,R)-form has similar properties but is –ve in M HCl and +ve in H2O. [du Vigneaud & Patterson J Biol Chem 109 101 1935, du Vigneaud & Brown Biochemical Preparations 5 93, 95 1975, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2667-2670 1961, Beilstein 4 III 1643, 4 IV 3199, Koegel et al. J Am Chem Soc 77 5708 1955.]

L-Homocystine Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Homocystine Suppliers

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View Lastest Price from L-Homocystine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: L-Homocystine 626-72-2
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-17

WUHAN FORTUNA CHEMICAL CO., LTD

Product: L-Homocystine 626-72-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 5000kg/month
Release date: 2021-10-13

Henan Bao Enluo International TradeCo.，LTD

Product: L-Homocystine 626-72-2
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500t/month
Release date: 2023-08-01

626-72-2, L-HomocystineRelated Search:

4-Aminobutyric acid D-2-Aminobutyric acid N-Acetyl-L-cysteine DL-Homocysteine L-Cystine DL-2-AMINOBUTYRIC ACID L-Cysteine Selenium sulfide DL-3-Aminobutyric acid Indole-3-butyric acid DL-2-Aminobutyric acid L(+)-2-Aminobutyric acid Cyproterone acetate 3-CARBOXYPROPYL DISULFIDE Butyl disulfide Methyl propyl disulfide r-Amino Butryric Acid ETHYL PROPYL DISULFIDE

(2S,2'S)-2,2'-Diamino-(4,4'-dithiobisbutyric acid)

3,3'-(Dithiobismethylene)bisalanine

4,4'-Dithiobis[(2S)-2-aminobutanoic acid]

4,4'-Dithiobis[(S)-2-aminobutanoic acid]

4,4'-Dithiobis[(S)-2-aminobutyric acid]

(2S,2'S)-4,4'-Disulfanediylbis(2-aMinobutanoic acid)

(2S,2'S)-4,4'-Dithiobis[2-aMinobutanoic Acid]

[S-(R*,R*)]-4,4'-Dithiobis[2-aMinobutanoic Acid]

L-Homocystine ,99%

L-Homocystine,L-4,4′-Dithiobis(2-aminobutanoic acid)

L-HOMOCYSTINE, >=98% (HPLC)

(H-L-HomoCys-OH)2

L-Homocystine≥ 99% (Assay)

H-HoCys-OH L-4,4'-Dithiobis(2-aminobutanoic acid)

(H-HCY-OH)2

(H-HOCYS-OH)2

(H-HOMOCYS-OH)2

H-L-HOCYSTINE

L-4,4'-DITHIO-BIS(2-AMINOBUTANOIC ACID)

4,4’-dithiobis[2-amino-,[s-(theta,theta)]-butanoicaci

(H-Hcy-OH)?

L-homocystine cell culture tested

[S-(R*,R*)]-4,4'-dithiobis[2-aminobutyric] acid

2-amino-4-(3-amino-3-carboxy-propyl)disulfanyl-butanoic acid

H-HoCys-OH

(H-Hcys-OH) 2

L-Homocystine

H-L-HCystine

(2S)-2-amino-4-{[(3S)-3-amino-3-carboxypropyl]disulfanyl}butanoic acid

Butanoic acid, 4,4'-dithiobis[2-amino-, (2S,2'S)-

L-Homocystine USP/EP/BP

L Homocystine,Inhibitor,Endogenous Metabolite,LHomocystine,inhibit,L-Homocystine

Vincamine Impurity 1( Vincamine EP Impurity A )

<sc>L</sc>-Homocystine

(2S)-2-Amino-4-[[(3S)-3-amino-4-hydroxy-4-oxo-butyl]disulfanyl]butanoic acid

626-72-2

C8H16N2O4S2

Unnatural Amino Acid Derivatives

Specialty Synthesis

Peptide Synthesis

Homo-Amino Acids

Amines

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

Amino Acids