4-Methoxyphenyl isocyanate Property

Melting point:

101 °C

Boiling point:

106-110 °C16 mm Hg(lit.)

Density 

1.151 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.548(lit.)

Flash point:

209 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

soluble in Chloroform, Methanol

form 

Liquid

Specific Gravity

1.151

color 

Clear colorless

Sensitive 

Moisture Sensitive

BRN 

471920

CAS DataBase Reference

5416-93-3(CAS DataBase Reference)

NIST Chemistry Reference

P-methoxy phenyl isocyanate(5416-93-3)

EPA Substance Registry System

Benzene, 1-isocyanato-4-methoxy- (5416-93-3)

Safety

Hazard Codes 

C,Xi

Risk Statements 

20/21/22-34-36/37/38

Safety Statements 

26-36/37/39-45-37/39

RIDADR 

UN 2206 6.1/PG 3

WGK Germany 

3

F 

10-21

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29291090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-Methoxyphenyl isocyanate Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

4-Methoxyphenyl isocyanate has been used in the preparation of:

• 6H-indolo[2,3-b]quinolines
• 1-[2-(2-furyl)-8-methyl-9-substituted-8H-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c] pyrimidin-5-yl]-3-(4-methoxyphenyl)urea

Synthesis Reference(s)

Tetrahedron Letters, 17, p. 2691, 1976 DOI: 10.1016/S0040-4039(00)77797-5

General Description

Cyclotrimerization of 4-methoxyphenyl isocyanate by CO₂-protected N-heterocyclic carbenes based on tetrahydropyrimidin-2-ylidenes has been reported.