ChemicalBook > CAS DataBase List > Methylprednisolone sodium succinate

Methylprednisolone sodium succinate

Product Name
Methylprednisolone sodium succinate
CAS No.
2375-03-3
Chemical Name
Methylprednisolone sodium succinate
Synonyms
METHYLPREDNISOLONE SODIUM SUCCINATE;6α-methylprednisolone 21-hemisuccinate sodium salt;1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-SUCCINATE, SODIUM SALT;6ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT;(6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione monosodium salt;u9088;Metypred;NSC 48989;succinate);solu-medrol
CBNumber
CB5163715
Molecular Formula
C26H33O8.Na
Formula Weight
496.53
MOL File
2375-03-3.mol
More
Less

Methylprednisolone sodium succinate Property

Melting point:
>186°C (dec.)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
lyophilized powder
color 
White to Off-White
InChIKey
FQISKWAFAHGMGT-JXAFMBTDNA-M
SMILES
[C@]12(C[C@@H](C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@H](C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)CCC([O-])=O)O)C)[H].[Na+] |&1:0,2,9,11,13,15,17,20,r|
CAS DataBase Reference
2375-03-3(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
T
Risk Statements 
61-40
Safety Statements 
53-22-36/37/39-45
WGK Germany 
3
RTECS 
TU4154060
Toxicity
LD50 oral in rat: > 5gm/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H351Suspected of causing cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M3781
Product name
6α-Methylprednisolone 21-hemisuccinate sodium salt
Purity
lyophilized powder
Packaging
25MG
Price
$78.7
Updated
2023/06/20
Sigma-Aldrich
Product number
M3781
Product name
6α-Methylprednisolone 21-hemisuccinate sodium salt
Purity
lyophilized powder
Packaging
250MG
Price
$411
Updated
2023/06/20
Sigma-Aldrich
Product number
M3781
Product name
6α-Methylprednisolone 21-hemisuccinate sodium salt
Purity
lyophilized powder
Packaging
1G
Price
$1300
Updated
2023/06/20
Usbiological
Product number
220287
Product name
Succinate
Packaging
100Tests
Price
$1048
Updated
2021/12/16
TRC
Product number
M326725
Product name
6α-Methylprednisolone21-HemisuccinateSodiumSalt
Packaging
100mg
Price
$140
Updated
2021/12/16
More
Less

Methylprednisolone sodium succinate Chemical Properties,Usage,Production

Description

Methylprednisolone Sodium Succinate is the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. It is converted into active prednisolone in the body, which activates glucocorticoid receptor-mediated gene expression. This includes inducing the synthesis of the anti-inflammatory protein IkappaB-alpha and inhibiting the synthesis of nuclear factor kappa B (NF-kappaB). As a result, proinflammatory cytokine production, such as IL-1, IL-2, and IL-6, is down-regulated, and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.

Uses

6α-Methylprednisolone 21-Hemisuccinate is a glucocorticosteroid used in anti-inflammatory medication in the treatment of spinal cord injuries.

Uses

6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.

Definition

ChEBI: Methylprednisolone sodium succinate is a corticosteroid hormone.

brand name

A-Methapred (Abbott); A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn).

Biochem/physiol Actions

Glucocorticoid with slightly longer half-life than that of prednisolone.

Side effects

Methylprednisolone Sodium Succinate is commonly given by injection and common side effects include: injection site pain/redness/swelling, nausea, vomiting, heartburn, headache, dizziness, difficulty sleeping, appetite changes, increased sweating, acne, increased blood sugar, sore throat, fever, chills, cough, white spots in the mouth. Serious side effects manifest as abnormal weight gain, menstrual disorders, bone/joint pain, easy bruising/bleeding, mental/mood changes, fast/slow/irregular heartbeat, stomach/intestinal bleeding symptoms, seizures, liver problems, and symptoms of severe allergic reactions. Contact your doctor if any of these serious adverse symptoms occur.

Methylprednisolone sodium succinate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Methylprednisolone sodium succinate Suppliers

Canada 1 China 101 Europe 2 Germany 1 India 10 Switzerland 1 United Kingdom 3 United States 27 Global 146
Wuhan Jingkangen Biomedical Technology Co., Ltd
Tel
13720134139 13720134139
Email
orders@jknbiochem.com
Country
China
ProdList
5797
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9958
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
10007
Advantage
58
Conier Chem & Pharma Limited
Tel
13368167990
Email
sales@conier.com
Country
China
ProdList
2830
Advantage
58
GUANGZHOU CHANGTHINKING IMP.&EXP.CO.,LTD
Tel
020-37651955 13682223272
Fax
020-87659730
Email
173901442@qq.com
Country
China
ProdList
694
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
TOSUN PHARM
Tel
020-61855200 13326451905
Email
260366801@qq.com
Country
China
ProdList
7781
Advantage
58
Shanghai Fuyi Biological Technology Co., Ltd.
Tel
18096642264
Email
sales@foreversyn.com
Country
China
ProdList
492
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
sales@afinechem.com
Country
China
ProdList
15352
Advantage
58
Xiamen AmoyChem Co., Ltd
Tel
+86-86-5926051114 +8618959220845
Email
sales@amoychem.com
Country
China
ProdList
6383
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22963
Advantage
58
Hefei fuya biotechnology co. LTD
Tel
18096409024
Email
sales02@foreversyn.com
Country
China
ProdList
1917
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49374
Advantage
58
Wuhan Yanzhe Technology Co., Ltd
Tel
15527250409
Fax
QQ：2692360204
Email
wenhaotian12@163.com
Country
China
ProdList
4495
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
DONBOO AMINO ACID COMPANY
Tel
+8613063595538
Email
donboo@donboo.com
Country
China
ProdList
9363
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
7976
Advantage
58
Mainchem Co., Ltd.
Tel
--
Fax
--
Email
sarah@mainchem.com
Country
China
ProdList
6567
Advantage
58
Hubei yongkuo Technology Co., Ltd
Tel
027-59223108 15972152991
Fax
027-59223108
Email
1248580099@qq.com
Country
China
ProdList
9988
Advantage
58
Hubei Xinkang Pharmaceutical Chemical Co., Ltd
Tel
027-59308705 18871579363
Fax
027-59308705
Email
1248180077@qq.com
Country
China
ProdList
9949
Advantage
58
Hubei Shishun Biotechnology Co. Ltd
Tel
027-59223025 15107168801
Fax
027-59223025
Email
1718480011@qq.com
Country
China
ProdList
9865
Advantage
58
Hubei Baidu Chemical Co., Ltd
Tel
027-59106051 13627137652
Fax
027-59223020
Email
1438180055@qq.com
Country
China
ProdList
9965
Advantage
58
Hubei Guangao Biotechnology Co., Ltd
Tel
027-027-59223056 18162699093
Fax
027-59223056
Email
1208480011@qq.com
Country
China
ProdList
9924
Advantage
58
Hubei Wande Chemical Co., Ltd
Tel
027-59210159 15377098680
Fax
027-59210159
Email
1148280011@qq.com
Country
China
ProdList
9961
Advantage
58
Tianmen Hengchang Chemical Co., Ltd
Tel
027-59322316 15172518801
Fax
027-59322316
Email
1208480077@qq.com
Country
China
ProdList
9882
Advantage
58
Hubei Qifei Pharmaceutical Chemical Co., Ltd
Tel
027-027-59322506 18071128681
Fax
027-59322506
Email
1438082200@qq.com
Country
China
ProdList
9976
Advantage
58
Hubei xingongli Chemical Co., Ltd
Tel
027-59106151 15172325309
Fax
027-59503710
Email
1400858877@qq.com
Country
China
ProdList
9937
Advantage
58
Shenzhen Shengda Pharmaceutical co Limited
Tel
0755-85269922 13424394241
Fax
QQ:1799060443
Email
sales@shengdapharm.com
Country
China
ProdList
505
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-61856358 15229202216
Fax
029-88380327
Email
1020@dideu.com
Country
China
ProdList
10007
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
027-81302411 15377658509
Email
zs@dkybpc.com
Country
China
ProdList
2196
Advantage
58
Hubei Kele Fine Chemical Co., Ltd
Tel
027-59101668 19945030958
Fax
027-59101668
Email
2881924765@qq.com
Country
China
ProdList
8099
Advantage
58
ChemeGen 中国
Tel
18818260767
Fax
QQ 3610331285
Email
2625930290@qq.com
Country
China
ProdList
6973
Advantage
58
Wuhan Augda Biotechnology Co., Ltd
Tel
15071299552
Fax
QQ:262933239
Email
262933239@qq.com
Country
China
ProdList
6886
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62075
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
Wuhan Beileye Biomedical Technology Co., Ltd.
Tel
18086118078
Email
2696158611@qq.com
Country
China
ProdList
4277
Advantage
58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
Tel
+86-027-59232304 15387063101
Email
2881924050@qq.com
Country
China
ProdList
9953
Advantage
58

2375-03-3, Methylprednisolone sodium succinateRelated Search:

Kresoxim-methyl Trisodium phosphate Sodium acetate Thiophanate-methyl Methylprednisolone acetate Bensulfuron methyl Sodium bicarbonate Methyl acrylate Prednisolone-21-acetate Sodium benzoate Methylparaben Diclofenac sodium Sodium hydroxide Sodium chloride Methylprednisolone Hydrocortisone sodium succinate Prednisolone Disodium succinate

  • (6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione monosodium salt
  • 6ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT
  • 6ALPHA-METHYLPREDNISOLONE 21-HEMISUCCINATE SODIUM SALT
  • 6-ALPHA-METHYLPREDNISOLONE SODIUM SUCCINATE
  • 1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-SUCCINATE, SODIUM SALT
  • 6α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate
  • 6α-methylprednisolone 21-hemisuccinate sodium salt
  • Methylprednisolone sodium succinate (JAN/USP)
  • 6a-Methylprednisolone 21-sodium hemisuccinate
  • 6a-Methylprednisolone 21-sodium succinate
  • 6a-Methylprednisolone sodium hemisuccinate
  • 6a-Methylprednisolone sodium succinate
  • 6a-Methylpregnisolone 21-sodium succinate
  • 6-Methylprednisolone sodium succinate
  • Metypred
  • NSC 48989
  • Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-6a-methyl-, 21-(hydrogen succinate), monosodium salt (8CI)
  • Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-6a-methyl-, 21-(hydrogen succinate), sodium salt (6CI, 7CI)
  • METHPREDNISOLONE SODIUM SUCCINATE
  • METHYLPREDNISOLONE SODIUM SUCCINATE
  • solu-medrone
  • succinate)
  • u9088
  • urbasonsolubile
  • Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodium salt, (6alpha,11beta)-
  • Methylprodnisolone Sodium Succinate
  • Methylprednisolone Succinate BP93,USP26
  • 11-beta,17,21-trihydroxy-6-alpha-methyl-1,4-pregnadiene-3,20-dione21-(sodium
  • 4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-(hyd
  • 6a-methylprednisolone21-hemisuccinate*sodium
  • rogensuccinate),monosodiumsalt
  • solu-medrol
  • Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodium salt, (6a,11b)- (9CI)
  • Sodium methylprednisolone succinate
  • Succinic acid, 21-monoester with 11b,17,21-trihydroxy-6a-methylpregna-1,4-diene-3,20-dione, monosodium salt (8CI)
  • 21-(3-Sodiooxycarbonyl-1-oxopropoxy)-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione
  • Sol-Melcort
  • 6alpha-Methylprednis
  • Methylprednisolone SodiuM Succinate Sterile Buffer
  • MethylprednisoloneSodiuM-SuccinateforInjection
  • 6a-Methylprednisolone 21-succinate sodium
  • 21-Succinate sodium salt
  • Pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-Methyl-, MonosodiuM salt, (6a,11b)-
  • 6α-Methylprednisolone 21-hemisuccinate Sodium
  • 6α-Methylprednisolone 21-hemisuccinate sodium salt
  • 6α-Methylprednisolone21-hemisuccinatesodiumsal
  • 1, 4-PREGNADIEN-6α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 21-SUCCINATE, SODIUM SALT
  • 6 alpha-Methylprednisolone Sodium Hemisuccinate
  • Sodium 4-(2-((6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy)-4-oxobutanoate
  • Levocarnitine Impurity 58
  • 2375-03-3
  • 2375-3-3
  • 2374-03-3
  • 173553
  • C26H33NaO8
  • C26H34O8Na
  • C26H33O8Na
  • Hormones