Methylprednisolone sodium succinate
- Product Name
- Methylprednisolone sodium succinate
- CAS No.
- 2375-03-3
- Chemical Name
- Methylprednisolone sodium succinate
- Synonyms
- METHYLPREDNISOLONE SODIUM SUCCINATE;6α-methylprednisolone 21-hemisuccinate sodium salt;1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-SUCCINATE, SODIUM SALT;6ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT;(6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione monosodium salt;u9088;Metypred;NSC 48989;succinate);solu-medrol
- CBNumber
- CB5163715
- Molecular Formula
- C26H33O8.Na
- Formula Weight
- 496.53
- MOL File
- 2375-03-3.mol
Methylprednisolone sodium succinate Property
- Melting point:
- >186°C (dec.)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- lyophilized powder
- color
- White to Off-White
- InChIKey
- FQISKWAFAHGMGT-JXAFMBTDNA-M
- SMILES
- [C@]12(C[C@@H](C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@H](C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)CCC([O-])=O)O)C)[H].[Na+] |&1:0,2,9,11,13,15,17,20,r|
- CAS DataBase Reference
- 2375-03-3(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- Risk Statements
- 61-40
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
- RTECS
- TU4154060
- Toxicity
- LD50 oral in rat: > 5gm/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H351Suspected of causing cancer
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M3781
- Product name
- 6α-Methylprednisolone 21-hemisuccinate sodium salt
- Purity
- lyophilized powder
- Packaging
- 25MG
- Price
- $78.7
- Updated
- 2023/06/20
- Product number
- M3781
- Product name
- 6α-Methylprednisolone 21-hemisuccinate sodium salt
- Purity
- lyophilized powder
- Packaging
- 250MG
- Price
- $411
- Updated
- 2023/06/20
- Product number
- M3781
- Product name
- 6α-Methylprednisolone 21-hemisuccinate sodium salt
- Purity
- lyophilized powder
- Packaging
- 1G
- Price
- $1300
- Updated
- 2023/06/20
- Product number
- 220287
- Product name
- Succinate
- Packaging
- 100Tests
- Price
- $1048
- Updated
- 2021/12/16
- Product number
- M326725
- Product name
- 6α-Methylprednisolone21-HemisuccinateSodiumSalt
- Packaging
- 100mg
- Price
- $140
- Updated
- 2021/12/16
Methylprednisolone sodium succinate Chemical Properties,Usage,Production
Description
Methylprednisolone Sodium Succinate is the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. It is converted into active prednisolone in the body, which activates glucocorticoid receptor-mediated gene expression. This includes inducing the synthesis of the anti-inflammatory protein IkappaB-alpha and inhibiting the synthesis of nuclear factor kappa B (NF-kappaB). As a result, proinflammatory cytokine production, such as IL-1, IL-2, and IL-6, is down-regulated, and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.
Uses
6α-Methylprednisolone 21-Hemisuccinate is a glucocorticosteroid used in anti-inflammatory medication in the treatment of spinal cord injuries.
Uses
6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.
Definition
ChEBI: Methylprednisolone sodium succinate is a corticosteroid hormone.
brand name
A-Methapred (Abbott); A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn).
Biochem/physiol Actions
Glucocorticoid with slightly longer half-life than that of prednisolone.
Side effects
Methylprednisolone Sodium Succinate is commonly given by injection and common side effects include: injection site pain/redness/swelling, nausea, vomiting, heartburn, headache, dizziness, difficulty sleeping, appetite changes, increased sweating, acne, increased blood sugar, sore throat, fever, chills, cough, white spots in the mouth. Serious side effects manifest as abnormal weight gain, menstrual disorders, bone/joint pain, easy bruising/bleeding, mental/mood changes, fast/slow/irregular heartbeat, stomach/intestinal bleeding symptoms, seizures, liver problems, and symptoms of severe allergic reactions. Contact your doctor if any of these serious adverse symptoms occur.
Methylprednisolone sodium succinate Preparation Products And Raw materials
Raw materials
Preparation Products
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