4-Aminoisoquinoline
- Product Name
- 4-Aminoisoquinoline
- CAS No.
- 23687-25-4
- Chemical Name
- 4-Aminoisoquinoline
- Synonyms
- ISOQUINOLIN-4-AMINE;NSC 170840;4-ISOQUINOLINAMINE;4-isoquinolylamine;4-lsoquinolylamine;4-AMINOISOQUINOLINE;isoqulinolin-4-amine;Isoquinolin-4-ylamine;4-Aminoisoquinoline >4-Aminoisoquinoline 97%
- CBNumber
- CB5172029
- Molecular Formula
- C9H8N2
- Formula Weight
- 144.17
- MOL File
- 23687-25-4.mol
4-Aminoisoquinoline Property
- Melting point:
- 108.0 to 112.0 °C
- Boiling point:
- 360.0±17.0 °C(Predicted)
- Density
- 1.210±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 6.29±0.10(Predicted)
- color
- White to Brown
- InChI
- InChI=1S/C9H8N2/c10-9-6-11-5-7-3-1-2-4-8(7)9/h1-6H,10H2
- InChIKey
- ISIUXVGHQFJYHM-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=CC=C2)C(N)=CN=1
- CAS DataBase Reference
- 23687-25-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 734225
- Product name
- 4-Aminoisoquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $40
- Updated
- 2023/06/20
- Product number
- A2595
- Product name
- 4-Aminoisoquinoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- A2595
- Product name
- 4-Aminoisoquinoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $178
- Updated
- 2025/07/31
- Product number
- A611600
- Product name
- 4-AminoIsoquinoline
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- A611600
- Product name
- 4-AminoIsoquinoline
- Packaging
- 10g
- Price
- $1100
- Updated
- 2021/12/16
4-Aminoisoquinoline Chemical Properties,Usage,Production
Uses
4-Isoquinolylamine can be used for synthesis of Rho kinase inhibitors.
Synthesis Reference(s)
Journal of the American Chemical Society, 64, p. 783, 1942 DOI: 10.1021/ja01256a012
Synthesis
881668-81-1
23687-25-4
A mixture of N-benzyl-4-aminoisoquinoline (1.00 g, 4.27 mmol) was reacted with a mixture of acetic acid (30 mL) and H2SO4 (7.5 mL, concentration not specified) for 6 hours at 100 °C with stirring. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with saturated aqueous NaHCO3 solution. Subsequently, Na2CO3 (200 mL) was added and diluted with water, followed by extraction with EtOAc (5 x 25 mL). The organic phases were combined, concentrated and the residue was purified by chromatography (eluent: EtOAc) to afford the target compound 4-aminoisoquinoline (325 mg, 53% yield) as a yellow solid.1H NMR (DMSO-d6, 400 MHz) δ 8.49 (s, 1H), 8.10 (d, 1H), 7.90 (d, 1H), 7.87 (s, 1H ), 7.64-7.54 (m, 2H), 5.82 (s, 2H).
Solubility in organics
4-isoquinolamine (4-Aminoisoquinoline) is slightly soluble in water and more soluble in organic solvents such as ethanol, dimethylformamide and dichloromethane.
References
[1] Patent: WO2006/32851, 2006, A1. Location in patent: Page/Page column 49
4-Aminoisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Aminoisoquinoline Suppliers
- Tel
- --
- Fax
- --
- info@specs.net
- Country
- The Netherlands
- ProdList
- 6833
- Advantage
- 70
View Lastest Price from 4-Aminoisoquinoline manufacturers
- Product
- 4-Aminoisoquinoline 23687-25-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-23
- Product
- 4-Isoquinolylamine 23687-25-4
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-25