Levobunolol hydrochloride
- Product Name
- Levobunolol hydrochloride
- CAS No.
- 27912-14-7
- Chemical Name
- Levobunolol hydrochloride
- Synonyms
- AG-901;w7000a;betagan;gotensin;vistagan;(-)-rochlorid;LEVOBUNOLOL HCL;l-bunololhydrochloride;LEVOBUNOLOL HYDROCHLORIDE;Levobunolol Hydrochloride (200 mg)
- CBNumber
- CB5173293
- Molecular Formula
- C17H26ClNO3
- Formula Weight
- 327.85
- MOL File
- 27912-14-7.mol
Levobunolol hydrochloride Property
- Melting point:
- 209-211°
- alpha
- 24589 -19.6±0.7° (c = 2.90 in methanol)
- storage temp.
- Amber Vial, Refrigerator, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Light Sensitive
Safety
- HS Code
- 2922504500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H319Causes serious eye irritation
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21005
- Product name
- Levobunolol (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 21005
- Product name
- Levobunolol (hydrochloride)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 21005
- Product name
- Levobunolol (hydrochloride)
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $336
- Updated
- 2024/03/01
- Product number
- L335000
- Product name
- LevobunololHydrochloride
- Packaging
- 100mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- API0003157
- Product name
- LEVOBUNOLOL HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $255.15
- Updated
- 2021/12/16
Levobunolol hydrochloride Chemical Properties,Usage,Production
Description
Levobunolol hydrochloride is a non-selective β-adrenergic blocker useful in the treatment of glaucoma. Worldwide, it represents the sixth B-blocker to be launched for this indication.
Originator
Warner Lambert (USA)
Uses
Anti-adrenergic (β-receptor).
Uses
A non-selective ?-adrenoceptor antagonist used as an anticonvulsant.
Definition
ChEBI: A hydrochloride obtained by combining equimolar amounts of levobunolol and hydrochloric acid. A non-selective beta-adrenergic antagonist used for treatment of glaucoma.
Manufacturing Process
9.62 g (59 mmoles) 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone, 67 ml
toluene, 0.36 g (1.1 mmoles) tetra-n-butylammonium bromide, 4.51 g (68
mmoles) 85% potassium hydroxide and 20 ml (254 mmoles) (R)-(-)-
epichlorhydrine were placed in an appropriate flask fitted with efficient
mechanical stirring, and the mixture was heated under reflux for two hours.
The mixture was allowed to cool to 30°C, 50 ml toluene and 50 ml water were
added and the mixture was vigorously stirred. The organic phase was
removed and the aqueous phase extracted with 25 ml toluene. The combined
organic phases were concentrated at reduced pressure, 31 ml (300 mmoles)
tert-butylamine, 45 ml ethanol and 3 ml deionized water were added, and the
solution was heated under reflux for one hour. The mixture was allowed to
cool to 40°C and the volatile products were distilled at reduced pressure.
Toluene (9 ml) was added to the residue and volatiles were distilled at
reduced pressure. (S)-5-(2,3-Epoxypropoxy)-3,4-dihydro-1(2H)-
naphthalenone with an optical purity greater than 95% was obtained. Toluene
(75 ml) was added to the product, and then, 10 ml of 35% (w/v) hydrochloric
acid and 110 ml water, and the mixture was stirred for fifteen minutes. The
organic phase was decanted and the aqueous one was extracted with 50 ml
toluene. The aqueous phase was basified by addition of a solution of 5.1 g
sodium hydroxide in 150 ml water and extracted twice with toluene (100 and
50 ml, respectively). The combined organic extracts were dried with
anhydrous sodium sulfate, decolorized with active charcoal and filtered.
To the above toluenic solution containing levobunolol as free base, 16 ml
ethanol and the stoichiometric amount of hydrogen chloride were added. The
stirred mixture was cooled below 10°C and kept at this temperature for one
hour. The precipitated solid was filtered, washed with toluene, recrystallized
twice from 43 ml ethanol and dried to give 10.0 g (51% yield) of (-)-3,4-
dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2H)-naphthalenone
hydrochloride (levobunolol hydrochloride) having a rotary power at 25°C
below -19°.
brand name
Akbeta(Akorn); Betagan(Allergan);VISTAGEN LIQUIFILM.
Therapeutic Function
Beta-adrenergic blocker
Veterinary Drugs and Treatments
Levobunolol HCl is a beta1- and beta2-blocking agent similar to timolol and metipranolol above but without the potential for myocardial depression or airway constriction noted rarely in veterinary medicine and occasionally in human patients. Levobunolol is used in humans with glaucoma responsive to beta adrenergic blocking agents but who suffer cardiac and respiratory side effects associated with timolol. Levobunolol HCl and then carteolol HCl would be suitable Beta blocking agents for feline patients with glaucoma and asthma, although carbonic anhydrase inhibitors should be used in such cases prior to adding a Beta blocking agent.
Levobunolol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Levobunolol hydrochloride manufacturers
- Product
- Levobunolol hydrochloride 27912-14-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 85.0-99.8%
- Supply Ability
- 20tons
- Release date
- 2020-10-28