PHOSPHORAMIDON
- Product Name
- PHOSPHORAMIDON
- CAS No.
- 119942-99-3
- Chemical Name
- PHOSPHORAMIDON
- Synonyms
- NSC 694280;PHOSPHORAMIDON;PhosphoraMidon sodiuM;PHOSPHATIDYL DIPEPTIDE;Phophoramidon disodium;PhosphoraMidon disodiuM sa;Phosphoramidon disodium salt;PhosphoraMidon research grade;PhosphoD23-RAMidon disodiuM salt;N-(ALPHA-RHAMNOPYRANOSYLPHOS.)-L-LEUCYL&
- CBNumber
- CB5184723
- Molecular Formula
- C23H35N3NaO10P
- Formula Weight
- 567.51
- MOL File
- 119942-99-3.mol
PHOSPHORAMIDON Property
- storage temp.
- -20°C
- solubility
- H2O: 1 mM Stock solution stable for 1 month at –20° C.
- form
- Solid
- color
- White to pale yellow
- BRN
- 8105669
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- R7385
- Product name
- Phosphoramidon disodium salt
- Purity
- ≥97% (HPLC)
- Packaging
- 0.5mg
- Price
- $83.7
- Updated
- 2024/03/01
- Product number
- R7385
- Product name
- Phosphoramidon disodium salt
- Purity
- ≥97% (HPLC)
- Packaging
- 1mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 525276
- Product name
- Phosphoramidon, Disodium Salt
- Purity
- Inhibits some metalloendopeptidases.
- Packaging
- 5mg
- Price
- $272
- Updated
- 2024/03/01
- Product number
- J63456
- Product name
- Phosphoramidon disodium salt, 97+%
- Packaging
- 5mg
- Price
- $336.65
- Updated
- 2024/03/01
- Product number
- R7385
- Product name
- Phosphoramidon disodium salt
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $324
- Updated
- 2024/03/01
PHOSPHORAMIDON Chemical Properties,Usage,Production
Description
Phosphoramidon (119942-99-3) inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC 3.4.24.11), Ki=2 nM.1?Also inhibits neprilysin 2 (Ki~2 nM).2?Also inhibits endothelin-converting enzyme (IC50?= 0.68 μM).3?Induces a dramatic increase in amyloid-beta levels in rodents.4
Uses
An endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.
Uses
Phosphoramidon is an inhibitor of NEP 24.11 and NEP2. It is an inhibitor of the enzyme thermolysin, a membrane metallo-endopeptidase inhibitor, and an endothelin converting enzyme inhibitor.
General Description
Phosphoramidon [N-(α-rhamnopyranosyl-oxyhydroxyphosphinyl)-Leu-Trp] is a competitive inhibitor of several soluble zinc metalloproteases. Phosphoramidate is produced naturally by Streptomyces?tanashiensis.
Biochem/physiol Actions
Phosphoramidon can inhibit ZMPSTE24, an integral membrane protein zinc metalloprotease. It is capable of blocking thermolysin.
References
1) Stephenson and Kenny et al. (1987),?The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11.; Biochem. J.,?243?183. 2) Rose?et al.?(2002),?Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin; Biochem. J.,?363?697 3) Ahn?et al.?(1998),?Soluble human endothelin-converting enzyme-1: expression, purification, and demonstration of pronounced pH sensitivity; Arch. Biochem. Biphys.,?359?258 4) Marr and Hafez (2014),?Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance; Front. Aging Neurosci.,?6?187
PHOSPHORAMIDON Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PHOSPHORAMIDON manufacturers
- Product
- PhosphoraMidon 119942-99-3
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2020-01-16
- Product
- Phosphoramidon disodium salt 119942-99-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 1000kg
- Release date
- 2018-12-25