PHOSPHORAMIDON

ChemicalBook > CAS DataBase List > PHOSPHORAMIDON

Product Name: PHOSPHORAMIDON
CAS No.: 119942-99-3
Chemical Name: PHOSPHORAMIDON
Synonyms: NSC 694280;PHOSPHORAMIDON;PhosphoraMidon sodiuM;PHOSPHATIDYL DIPEPTIDE;Phophoramidon disodium;PhosphoraMidon disodiuM sa;Phosphoramidon disodium salt;PhosphoraMidon research grade;PhosphoD23-RAMidon disodiuM salt;N-(ALPHA-RHAMNOPYRANOSYLPHOS.)-L-LEUCYL&
CBNumber: CB5184723
Molecular Formula: C23H35N3NaO10P
Formula Weight: 567.51
MOL File: 119942-99-3.mol

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PHOSPHORAMIDON Property

storage temp.: -20°C
solubility: H₂O: 1 mM Stock solution stable for 1 month at –20° C.
form: Solid
color: White to pale yellow
BRN: 8105669
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 2 months.

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10-21
HS Code: 2940000080

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R7385
Product name: Phosphoramidon disodium salt
Purity: ≥97% (HPLC)
Packaging: 0.5mg
Price: $83.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: R7385
Product name: Phosphoramidon disodium salt
Purity: ≥97% (HPLC)
Packaging: 1mg
Price: $144
Updated: 2024/03/01

Sigma-Aldrich

Product number: 525276
Product name: Phosphoramidon, Disodium Salt
Purity: Inhibits some metalloendopeptidases.
Packaging: 5mg
Price: $272
Updated: 2024/03/01

Alfa Aesar

Product number: J63456
Product name: Phosphoramidon disodium salt, 97+%
Packaging: 5mg
Price: $336.65
Updated: 2024/03/01

Sigma-Aldrich

Product number: R7385
Product name: Phosphoramidon disodium salt
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $324
Updated: 2024/03/01

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PHOSPHORAMIDON Chemical Properties,Usage,Production

Description

Phosphoramidon (119942-99-3) inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC 3.4.24.11), Ki=2 nM.1?Also inhibits neprilysin 2 (Ki~2 nM).2?Also inhibits endothelin-converting enzyme (IC50?= 0.68 μM).3?Induces a dramatic increase in amyloid-beta levels in rodents.4

Uses

An endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.

Uses

Phosphoramidon is an inhibitor of NEP 24.11 and NEP2. It is an inhibitor of the enzyme thermolysin, a membrane metallo-endopeptidase inhibitor, and an endothelin converting enzyme inhibitor.

General Description

Phosphoramidon [N-(α-rhamnopyranosyl-oxyhydroxyphosphinyl)-Leu-Trp] is a competitive inhibitor of several soluble zinc metalloproteases. Phosphoramidate is produced naturally by Streptomyces?tanashiensis.

Biochem/physiol Actions

Phosphoramidon can inhibit ZMPSTE24, an integral membrane protein zinc metalloprotease. It is capable of blocking thermolysin.

References

1) Stephenson and Kenny et al. (1987),?The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11.; Biochem. J.,?243?183. 2) Rose?et al.?(2002),?Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin; Biochem. J.,?363?697 3) Ahn?et al.?(1998),?Soluble human endothelin-converting enzyme-1: expression, purification, and demonstration of pronounced pH sensitivity; Arch. Biochem. Biphys.,?359?258 4) Marr and Hafez (2014),?Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance; Front. Aging Neurosci.,?6?187

PHOSPHORAMIDON Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PHOSPHORAMIDON manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: PhosphoraMidon 119942-99-3
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2020-01-16

Career Henan Chemical Co

Product: Phosphoramidon disodium salt 119942-99-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 1000kg
Release date: 2018-12-25

119942-99-3, PHOSPHORAMIDONRelated Search:

Palmitoyl Dipeptide-7 Glycyl-L-valine L-Alanyl-L-Glutamine N-Glycyl-L-leucine Glycyl-glycyl-L-valine N-Glycyl-L-isoleucine Gly-Gly-Leu Glycyl-L-glutamine monohydrate Glycyl-glycyl-glycine Glycylglycyl-L-isoleucine Muramyl Dipeptide GLYCYL-L-TRYPTOPHAN PHOSPHORAMIDON H-LEU-TRP-OH PHOSPHORAMIDON DISODIUM SALT,PHOSPHORAMIDON,PHOSPHORAMIDON DISODIUM SALT DIHYDRATE,PHOSPHORAMIDON SODIUM SALT L-ALANYL-L-TRYPTOPHAN PHOSPHORAMIDON--N/H PHOSPHORAMIDON NA 2H20

N-(A-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP

N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP-OH

PHOSPHORAMIDON

n-(α-rhamno-pyranosyl-oxy-hydroxy-phosphinyl)-leu-trp disodium salt

PHOSPHORAMIDON SODIUM SALT, FROM MICROBIAL SOURCE

N-(alpha-Rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp disodium salt

N-(alpha-rhamnopyranosylphos.)-L-leucyl-L-tryp. disod. salt

N-(A-rhamnopyranosyloxyhydroxy-*phosphinyl)-leu-T

N-(ALPHA-RHAMNOPYRANOSYLPHOS.)-L-LEUCYL&

PHOSPHATIDYL DIPEPTIDE

N-[[(6-Deoxy-a-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl- L-tryptophan Disodium Salt

NSC 694280

N-(α-Rhamnopyranosylphosphono)-L-leucyl-L-tryptophan disodium salt, N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp disodium salt

N-(α-Rhamnopyranosylphosphono)-L-leucyl-L-tryptophan disodium salt

Phosphoramidon disodium salt

PhosphoraMidon disodiuM sa

N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp

PhosphoraMidon research grade

PhosphoD23-RAMidon disodiuM salt

PhosphoraMidon sodiuM

L-Tryptophan,N-[[(6-deoxy-a-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl-,sodium salt (9CI)

Phosphoramidon disodium salt, ≥97% (HPLC)

Phophoramidon disodium

disodium,3-(1H-indol-3-yl)-2-[[4-methyl-2-[[oxido-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]pentanoyl]amino]propanoate

119942-99-3

C23H34N3O10P

C23H32N3Na2O10P

C23H32N3O10P2Na2H2O

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Type

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

Phosphodiesterase 3',5'-Cyclic Nucleotide

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peptides

inhibitor

Pepetides

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Intermediates & Fine Chemicals

Pharmaceuticals

Phosphorylating and Phosphitylating Agents