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PHOSPHORAMIDON

Product Name
PHOSPHORAMIDON
CAS No.
119942-99-3
Chemical Name
PHOSPHORAMIDON
Synonyms
NSC 694280;PHOSPHORAMIDON;PhosphoraMidon sodiuM;PHOSPHATIDYL DIPEPTIDE;Phophoramidon disodium;PhosphoraMidon disodiuM sa;Phosphoramidon disodium salt;PhosphoraMidon research grade;PhosphoD23-RAMidon disodiuM salt;N-(ALPHA-RHAMNOPYRANOSYLPHOS.)-L-LEUCYL&
CBNumber
CB5184723
Molecular Formula
C23H35N3NaO10P
Formula Weight
567.51
MOL File
119942-99-3.mol
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PHOSPHORAMIDON Property

storage temp. 
-20°C
solubility 
H2O: 1 mM Stock solution stable for 1 month at –20° C.
form 
Solid
color 
White to pale yellow
BRN 
8105669
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 2 months.
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10-21
HS Code 
2940000080
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R7385
Product name
Phosphoramidon disodium salt
Purity
≥97% (HPLC)
Packaging
0.5mg
Price
$83.7
Updated
2024/03/01
Sigma-Aldrich
Product number
R7385
Product name
Phosphoramidon disodium salt
Purity
≥97% (HPLC)
Packaging
1mg
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
525276
Product name
Phosphoramidon, Disodium Salt
Purity
Inhibits some metalloendopeptidases.
Packaging
5mg
Price
$272
Updated
2024/03/01
Alfa Aesar
Product number
J63456
Product name
Phosphoramidon disodium salt, 97+%
Packaging
5mg
Price
$336.65
Updated
2024/03/01
Sigma-Aldrich
Product number
R7385
Product name
Phosphoramidon disodium salt
Purity
≥97% (HPLC)
Packaging
5mg
Price
$324
Updated
2024/03/01
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PHOSPHORAMIDON Chemical Properties,Usage,Production

Description

Phosphoramidon (119942-99-3) inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC 3.4.24.11), Ki=2 nM.1?Also inhibits neprilysin 2 (Ki~2 nM).2?Also inhibits endothelin-converting enzyme (IC50?= 0.68 μM).3?Induces a dramatic increase in amyloid-beta levels in rodents.4

Uses

An endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.

Uses

Phosphoramidon is an inhibitor of NEP 24.11 and NEP2. It is an inhibitor of the enzyme thermolysin, a membrane metallo-endopeptidase inhibitor, and an endothelin converting enzyme inhibitor.

General Description

Phosphoramidon [N-(α-rhamnopyranosyl-oxyhydroxyphosphinyl)-Leu-Trp] is a competitive inhibitor of several soluble zinc metalloproteases. Phosphoramidate is produced naturally by Streptomyces?tanashiensis.

Biochem/physiol Actions

Phosphoramidon can inhibit ZMPSTE24, an integral membrane protein zinc metalloprotease. It is capable of blocking thermolysin.

References

1) Stephenson and Kenny et al. (1987),?The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11.; Biochem. J.,?243?183. 2) Rose?et al.?(2002),?Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin; Biochem. J.,?363?697 3) Ahn?et al.?(1998),?Soluble human endothelin-converting enzyme-1: expression, purification, and demonstration of pronounced pH sensitivity; Arch. Biochem. Biphys.,?359?258 4) Marr and Hafez (2014),?Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance; Front. Aging Neurosci.,?6?187

PHOSPHORAMIDON Preparation Products And Raw materials

Raw materials

Preparation Products

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PHOSPHORAMIDON Suppliers

Canada 1 China 110 Europe 2 Germany 4 India 1 Switzerland 1 United Kingdom 2 United States 14 Global 135
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from PHOSPHORAMIDON manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
PhosphoraMidon 119942-99-3
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2020-01-16
Career Henan Chemical Co
Product
Phosphoramidon disodium salt 119942-99-3
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
1000kg
Release date
2018-12-25

119942-99-3, PHOSPHORAMIDONRelated Search:

Palmitoyl Dipeptide-7 Glycyl-L-valine L-Alanyl-L-Glutamine N-Glycyl-L-leucine Glycyl-glycyl-L-valine N-Glycyl-L-isoleucine Gly-Gly-Leu Glycyl-L-glutamine monohydrate Glycyl-glycyl-glycine Glycylglycyl-L-isoleucine Muramyl Dipeptide GLYCYL-L-TRYPTOPHAN PHOSPHORAMIDON H-LEU-TRP-OH PHOSPHORAMIDON DISODIUM SALT,PHOSPHORAMIDON,PHOSPHORAMIDON DISODIUM SALT DIHYDRATE,PHOSPHORAMIDON SODIUM SALT L-ALANYL-L-TRYPTOPHAN PHOSPHORAMIDON--N/H PHOSPHORAMIDON NA 2H20

  • N-(A-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP
  • N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP-OH
  • PHOSPHORAMIDON
  • n-(α-rhamno-pyranosyl-oxy-hydroxy-phosphinyl)-leu-trp disodium salt
  • PHOSPHORAMIDON SODIUM SALT, FROM MICROBIAL SOURCE
  • N-(alpha-Rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp disodium salt
  • N-(alpha-rhamnopyranosylphos.)-L-leucyl-L-tryp. disod. salt
  • N-(A-rhamnopyranosyloxyhydroxy-*phosphinyl)-leu-T
  • N-(ALPHA-RHAMNOPYRANOSYLPHOS.)-L-LEUCYL&
  • PHOSPHATIDYL DIPEPTIDE
  • N-[[(6-Deoxy-a-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl- L-tryptophan Disodium Salt
  • NSC 694280
  • N-(α-Rhamnopyranosylphosphono)-L-leucyl-L-tryptophan disodium salt, N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp disodium salt
  • N-(α-Rhamnopyranosylphosphono)-L-leucyl-L-tryptophan disodium salt
  • Phosphoramidon disodium salt
  • PhosphoraMidon disodiuM sa
  • N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp
  • PhosphoraMidon research grade
  • PhosphoD23-RAMidon disodiuM salt
  • PhosphoraMidon sodiuM
  • L-Tryptophan,N-[[(6-deoxy-a-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl-,sodium salt (9CI)
  • Phosphoramidon disodium salt, ≥97% (HPLC)
  • Phophoramidon disodium
  • disodium,3-(1H-indol-3-yl)-2-[[4-methyl-2-[[oxido-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]pentanoyl]amino]propanoate
  • 119942-99-3
  • C23H34N3O10P
  • C23H32N3Na2O10P
  • C23H32N3O10P2Na2H2O
  • Enzymes, Inhibitors, and Substrates
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  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Phosphodiesterase 3',5'-Cyclic Nucleotide
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