Lomerizine hydrochloride

Product Name: Lomerizine hydrochloride
CAS No.: 101477-54-7
Chemical Name: Lomerizine hydrochloride
Synonyms: KB 2796;TERRANAS;Lomeizine HCL;Lomerizine2HCl;LOMERIZINE HCL;LOMERIZINE DIHCL;KB-2796, Terranas;KB-2796 dihydrochloride;LOMERIZINEHYDROCHLORTDE;LOMERIZINE HYDROCHLORIDE
CBNumber: CB5186585
Molecular Formula: C27H32Cl2F2N2O3
Formula Weight: 541.46
MOL File: 101477-54-7.mol

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Lomerizine hydrochloride Property

Melting point:: 214-218°C dec.
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: ≥30mg/mL
form: powder
color: white to tan
Merck: 14,5563
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
CAS DataBase Reference: 101477-54-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
RTECS: TK9189000
HS Code: 29335990
Toxicity: LD50 orally in mice: 300 mg/kg (Ohtaka)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L6295
Product name: Lomerizine dihydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 10mg
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: L6295
Product name: Lomerizine dihydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 50mg
Price: $416
Updated: 2024/03/01

TCI Chemical

Product number: L0245
Product name: Lomerizine Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $308
Updated: 2024/03/01

TCI Chemical

Product number: L0245
Product name: Lomerizine Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $90
Updated: 2024/03/01

Cayman Chemical

Product number: 28374
Product name: Lomerizine (hydrochloride)
Packaging: 250mg
Price: $68
Updated: 2024/03/01

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Lomerizine hydrochloride Chemical Properties,Usage,Production

Description

Lomerizine hydrochloride was introduced as Teranas and Migsis in Japan for the treatment of migraine. It is the first in its class of dual sodium and calcium channel blockers to be marketed for this indication. It can be synthetically obtained by reductive amination of 2,3,4-trimethoxybenzaldehyde with the appropiate benzhydryl piperazine. In dogs, Lomerizine exerts a potent, selective and long-lasting vasodilation of cerebral arteries related to a combination of mechanisms, especially a functional block of L-type voltagesensitive calcium channels (L-VSCCs). Lomerizine increases cerebral blood flow compared to peripheral blood flow with only weak effects on systemic arterial blood pressure. Other mechanisms involved could be blockade of other VSCC and sodium channels, 5-HT2 and alpha-1 receptors. As a reducing agent of cortical spreading depression and neurogenic inflammation, Lomerizine was shown to be useful in migraine. In an open clinical study, it demonstrated efficacy in the treatment of cluster headache. Moreover, it may have utility in other neurological diseases such as cerebrovascular ischemia or cerebral infarction.

Chemical Properties

Colourless Crystalline Solid

Originator

Akzo Nobel (Netherlands)

Uses

A diphenylpiperazine calcium channel blocker. A selective cerebral vasodilator. Antimigraine.

brand name

Teranas;Migsis

References

1) Ishii?et al. (2009), Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery; ?J. Pharmacol. Sci. 111 221 2)?Hara et al. (2004), Clinical potential of lomerizine, a Ca2+ channel blocker as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage; Cardiovasc.Drug Rev. 22 199 3)?Ishii et al. (2011), Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity; Mol. Cell Biochem. 358 1 4) Savigni?et al. (2013), Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma; ?Neuropharmacology 75 380 5) Tran?et al. (2014), The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD, but not TDP-43; ?J. Neurochem. 130 455 6) O’Hare?et al. (2016), Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro; ?Neuroscience 339 450

Lomerizine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Lomerizine hydrochloride Suppliers

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View Lastest Price from Lomerizine hydrochloride manufacturers

Career Henan Chemical Co

Product: Lomerizine hydrochloride 101477-54-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-11

101477-54-7, Lomerizine hydrochlorideRelated Search:

4,4'-Difluorobenzhydrylpiperazine Trimetazidine dihydrochloride (S)-1-(4-FLUOROPHENYL)ETHYLAMINE Lomerizine hydrochloride Lomerizine (R)-1-(4-Fluorophenyl)ethylamine (R)-1-(4-Fluorophenyl)ethylamine hydrochloride Belarizine PIPERAZINE DIHYDROCHLORIDE 1-(4-FLUORO-BENZYL)-PIPERAZINE 2HCL 1-(3,4-DIMETHOXY-BENZYL)-PIPERAZINE 1-(4-METHOXY-BENZYL)-PIPERAZINE DIHYDROCHLORIDE (S)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE (R)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE 1-[1-(4-FLUORO-PHENYL)-ETHYL]-PIPERAZINE C-(4-FLUORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE 1-(4-FLUORO-ALPHA-PHENYLBENZYL)PIPERAZINE (4-fluorophenyl)(phenyl)methylamine

1-(4,4'-Difluorobenzhydryl)-4-(2,3,4-trimethoxybenzyl)piperazine·dihydrochloride

Flometizine hydrochloride

Lomerizine dihydrochloride, 99%, a new L- and T-type calcium channel blocker

Lomerizine2HCl

KB-2796 dihydrochloride

Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)

Lomerizine dihydrochloride, >=99%

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

1-(2,3,4-trimethoxybenzyl)-4-(bis(4-fluorophenyl)methyl)piperazinedihydrochl

1-(bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)-piperazin

1-(bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)piperazined

TERRANAS

KB 2796

LOMERIZINE HCL

LOMERIZINE HYDROCHLORIDE

LOMERIZINE DIHCL

LOMERIZINE DIHYDROCHLORIDE

KB-2796, Terranas

LOMERIZINEHYDROCHLORTDE

Lomeizine HCL

1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride

LomerizineDihydrochloride&gt

Lomerizine hydrochloride USP/EP/BP

Lomerizine HCl (KB-2796)

101477-54-7

C27H32Cl2F2N2O3

C27H30F2N2O32HCl

C27H30F2N2O2

C27H25F2N2O32HCl

C27H30F2N2O32ClH

Inhibitors

APIs

Aromatics

Heterocycles

Heterocyclic Compounds

Intermediates & Fine Chemicals

Neurochemicals

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