ChemicalBook > CAS DataBase List > Propyphenazone

Propyphenazone

Product Name
Propyphenazone
CAS No.
479-92-5
Chemical Name
Propyphenazone
Synonyms
Budirol;Causyth;Larodon;Cibalgina;Isopyrine;Isopropchin;Isopropyrine;Propyphenazon;PROPYPHENAZONE;(-)-Asparagine
CBNumber
CB5193729
Molecular Formula
C14H18N2O
Formula Weight
230.31
MOL File
479-92-5.mol
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Propyphenazone Property

Melting point:
102-105°C
Boiling point:
372.3°C (rough estimate)
Density 
1.0371 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
pka
1.46±0.65(Predicted)
color 
White to Off-White
Water Solubility 
743.6g/L(25.35 ºC)
Merck 
14,7871
BRN 
204533
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
479-92-5(CAS DataBase Reference)
NIST Chemistry Reference
Propyphenazone(479-92-5)
EPA Substance Registry System
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl- (479-92-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39
WGK Germany 
3
RTECS 
CD2800000
HS Code 
2933.39.9200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1389
Product name
Propyphenazone
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$97.5
Updated
2024/03/01
TCI Chemical
Product number
I0656
Product name
4-Isopropylantipyrine
Purity
>98.0%(GC)
Packaging
25g
Price
$64
Updated
2024/03/01
Sigma-Aldrich
Product number
P3750000
Product name
Propyphenazone
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
p3750000
Price
$153
Updated
2024/03/01
TRC
Product number
P838380
Product name
Propyphenazone
Packaging
50g
Price
$875
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007224
Product name
PROPYPHENAZONE
Purity
95.00%
Packaging
25G
Price
$950
Updated
2021/12/16
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Propyphenazone Chemical Properties,Usage,Production

Description

This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known.

Chemical Properties

solid

Uses

Analgesic; antipyretic; anti-inflammatory.

Definition

ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group.

brand name

539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin.

World Health Organization (WHO)

Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations. See also WHO comment for aminophenazone.

Clinical Use

Propyphenazone is a derivative of phenazone and has a similar analgesic and antipyretic action. It is used as a monocompound as well as in multi-ingredient preparations.

References

Hartsen., J. Chem. Soc., 511 (1873) Mirande., Compt. rend., 168,316 (1919)

Propyphenazone Preparation Products And Raw materials

Raw materials

Preparation Products

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Propyphenazone Suppliers

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View Lastest Price from Propyphenazone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Propyphenazone 479-92-5
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-29
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Propyphenazone 479-92-5
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-10-29
Hebei Guanlang Biotechnology Co,.LTD
Product
Propyphenazone 479-92-5
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2021-08-27

479-92-5, PropyphenazoneRelated Search:

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