8-HYDROXY-7-METHOXYCOUMARIN
- Product Name
- 8-HYDROXY-7-METHOXYCOUMARIN
- CAS No.
- 19492-03-6
- Chemical Name
- 8-HYDROXY-7-METHOXYCOUMARIN
- Synonyms
- DAPHNETIN METHYL ETHER;Daphnetin 7-Methyl ethe;DAPHNETIN-7-METHYL ETHER;8-HYDROXY-7-METHOXYCOUMARIN;7-Methoxy-8-hydroxycoumarin;8-hydroxy-7-methoxychromen-2-one;8-Hydroxy-7-methoxy-2H-chromen-2-one;8-Hydroxy-7-methoxy-2H-1-benzopyran-2-one;7-Methoxy-8-hydroxy-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 8-hydroxy-7-methoxy-
- CBNumber
- CB5193941
- Molecular Formula
- C10H8O4
- Formula Weight
- 192.17
- MOL File
- 19492-03-6.mol
8-HYDROXY-7-METHOXYCOUMARIN Property
- Melting point:
- 176°C
- Boiling point:
- 381.9±42.0 °C(Predicted)
- Density
- 1.377
- pka
- 7.78±0.20(Predicted)
- BRN
- 168393
- LogP
- 0.620 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H533600
- Product name
- 8-Hydroxy-7-methoxycoumarin
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FH66318
- Product name
- 8-Hydroxy-7-methoxycoumarin
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FH66318
- Product name
- 8-Hydroxy-7-methoxycoumarin
- Packaging
- 250mg
- Price
- $207.5
- Updated
- 2021/12/16
- Product number
- FH66318
- Product name
- 8-Hydroxy-7-methoxycoumarin
- Packaging
- 50mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FH66318
- Product name
- 8-Hydroxy-7-methoxycoumarin
- Packaging
- 500mg
- Price
- $330
- Updated
- 2021/12/16
8-HYDROXY-7-METHOXYCOUMARIN Chemical Properties,Usage,Production
Uses
8-Hydroxy-7-methoxycoumarin is a phenylpropanoid isolated from the calyxes of Physalis alkekengi L. var. franchetii (Mast.) Makino. 8-Hydroxy-7-methoxycoumarin shows cytotoxicity against GLC4 and COLO 320 cancer cell after continuous incubation (4 days) with IC50s of 179 μM and 145 μM[1][2].
Definition
ChEBI: 8-Hydroxy-7-methoxy-2H-1-benzopyran-2-one is a hydroxycoumarin.
Synthesis
Preparation of 8-HYDROXY-7-METHOXYCOUMARIN (ryanodine-7-methyl ether) (??-aa): weighing 7,8-dihydroxycoumarin 500mg in a three-mouth bottle, adding N,N-dimethylformamide 5mL to dissolve the sample, adding sodium carbonate 850mg, stirring the reaction for 15min, adding iodomethane 560??L drop by drop, 0 ?? reaction, TLC to monitor the progress of the reaction, after 5h After the end of the reaction, the reaction solution was added dropwise to 100mL of ice water, hydrochloric acid was added to adjust the pH about 3, ethyl acetate extraction (50mL??3), combined with ethyl acetate phase, saturated brine washed twice, the organic phase was distilled under reduced pressure to remove the ethyl acetate, that is, the crude, the crude was separated on a silica gel column, the mobile phase was V petroleum ether: V dichloromethane: V acetone = 2:1:0.2, the solvent was removed by distillation under reduced pressure, the crude was separated by silica gel column, the mobile phase was V petroleum ether: V dichloromethane: V acetone = 2:1:0.2, the solvent was removed by distillation under reduced pressure, the crude was separated by a silica gel column. Vacuum drying, obtained white solid 260mg.
References
[1] HuiLv, et al. Chemical constituents from the calyxes of Physalis alkekengi L. var. franchetii (Mast.) Makino. Biochemical Systematics and Ecology, Volume 78, June 2018, Pages 63-65.
[2] H Kolodzie, et al. Structure-cytotoxicity relationships of a series of natural and semi-synthetic simple coumarins as assessed in two human tumour cell lines. Z Naturforsch C J Biosci. 1997 Mar-Apr;52(3-4):240-4. DOI:10.1515/znc-1997-3-416
8-HYDROXY-7-METHOXYCOUMARIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 8-HYDROXY-7-METHOXYCOUMARIN manufacturers
- Product
- 8-HYDROXY-7-METHOXYCOUMARIN 19492-03-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-24
- Product
- 8-HYDROXY-7-METHOXYCOUMARIN 19492-03-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-01
- Product
- 8-HYDROXY-7-METHOXYCOUMARIN 19492-03-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-07-09