2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE
- Product Name
- 2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE
- CAS No.
- 4055-69-0
- Chemical Name
- 2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE
- Synonyms
- AKOS 235-08;Trimetazidine Impurity 15;4-Piperidinepropanol,8-hydroxy-;2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE;4-METHOXY-2,3-DIHYDROXYBENZALDEHYDE;Benzaldehyde, 2,3-dihydroxy-4-methoxy-;2 3-DIHYDROXY-4-METHOXYBENZALDEHYDE 95%;4-METHOXY-2,3-DIHYDROXYBENZALDEHYDE 95%;Phosphorousacid,tris(1,3-dimethylethyl)ester
- CBNumber
- CB6305837
- Molecular Formula
- C8H8O4
- Formula Weight
- 168.15
- MOL File
- 4055-69-0.mol
2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE Property
- Melting point:
- 69.5 °C
- Boiling point:
- 172-178 °C
- Density
- 1.378±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Solid
- pka
- 7.63±0.15(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FD67774
- Product name
- 2,3-Dihydroxy-4-methoxybenzaldehyde
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FD67774
- Product name
- 2,3-Dihydroxy-4-methoxybenzaldehyde
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD67774
- Product name
- 2,3-Dihydroxy-4-methoxybenzaldehyde
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FD67774
- Product name
- 2,3-Dihydroxy-4-methoxybenzaldehyde
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FD67774
- Product name
- 2,3-Dihydroxy-4-methoxybenzaldehyde
- Packaging
- 2g
- Price
- $460
- Updated
- 2021/12/16
2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production
Uses
DHMB (2,3-Dihydroxy-4-methoxybenzaldehyde) is a small organic molecule with anti-fungal and anti-inflammatory activity. DHMB has protective effect on intestinal epithelial cells[1].
Synthesis Reference(s)
Synthetic Communications, 16, p. 645, 1986 DOI: 10.1080/00397918608057734
Synthesis
2103-57-3
19283-70-6
4055-69-0
General procedure for the synthesis of 2-hydroxy-3,4-dimethoxybenzaldehyde (29) and 2,3-dihydroxy-4-methoxybenzaldehyde (29') from 2,3,4-trimethoxybenzaldehyde: 2,3,4-trimethoxybenzaldehyde (5.00 g, 25.5 mmol) was dissolved in anhydrous dichloromethane (15 mL) at 0 °C and under nitrogen protection. Anhydrous boron trichloride (28.0 mL, 1.0 M solution in dichloromethane) was added slowly through a dropping funnel and the reaction mixture was stirred at this temperature for 5 hours. Upon completion of the reaction, the reaction was quenched with distilled water (10 mL), the organic phase was separated, and the aqueous phase was extracted with dichloromethane (2 x 25 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure. 2-Hydroxy-3,4-dimethoxybenzaldehyde (29) (3.75 g, 20.6 mmol, 81% yield) was obtained as a white powder, as well as 2,3-dihydroxy-4-methoxybenzaldehyde (29') (0.20 g, 1.2 mmol, 5% yield) as an off-white powder.1H NMR (500 MHz, CDCl3) δ 11.2 (1H, s 2-OH), 9.75 (1H, s, 1-CHO), 7.29 (1H, d, J=9.0Hz, 6-H), 6.61 (1H, d, J=9.0Hz, 5-H), 3.95 (3H, s, 4-OCH3), 3.91 (3H, s, 3-OCH3).13C NMR (126MHz, CDCl3) δ 194.9 (1-CHO), 159.4 (C-4), 155.7 (C-2), 136.2 (C-3), 130.2 (6-CH), 116.6 (C-1), 104.0 (5-CH), 60.8 (3-OCH3), 56.3 (4-OCH3).
References
[1] Bortolus C, et al. A Small Aromatic Compound Has Antifungal Properties and Potential Anti-Inflammatory Effects against Intestinal Inflammation. Int J Mol Sci. 2019 Jan 14;20(2):321. DOI:10.3390/ijms20020321
2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE manufacturers
- Product
- Trimetazidine Impurity 15 4055-69-0
- Price
- US $30.00-20.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2024-07-30
- Product
- 2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE 4055-69-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-08