ChemicalBook > CAS DataBase List > 2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE

2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE

Product Name
2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE
CAS No.
4055-69-0
Chemical Name
2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE
Synonyms
AKOS 235-08;Trimetazidine Impurity 15;4-Piperidinepropanol,8-hydroxy-;2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE;4-METHOXY-2,3-DIHYDROXYBENZALDEHYDE;Benzaldehyde, 2,3-dihydroxy-4-methoxy-;2 3-DIHYDROXY-4-METHOXYBENZALDEHYDE 95%;4-METHOXY-2,3-DIHYDROXYBENZALDEHYDE 95%;Phosphorousacid,tris(1,3-dimethylethyl)ester
CBNumber
CB6305837
Molecular Formula
C8H8O4
Formula Weight
168.15
MOL File
4055-69-0.mol
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2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE Property

Melting point:
69.5 °C
Boiling point:
172-178 °C
Density 
1.378±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
Solid
pka
7.63±0.15(Predicted)
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Safety

Hazard Codes 
Xi
Risk Statements 
36-43
Safety Statements 
26-36/37
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FD67774
Product name
2,3-Dihydroxy-4-methoxybenzaldehyde
Packaging
100mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD67774
Product name
2,3-Dihydroxy-4-methoxybenzaldehyde
Packaging
250mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD67774
Product name
2,3-Dihydroxy-4-methoxybenzaldehyde
Packaging
500mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD67774
Product name
2,3-Dihydroxy-4-methoxybenzaldehyde
Packaging
1g
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD67774
Product name
2,3-Dihydroxy-4-methoxybenzaldehyde
Packaging
2g
Price
$460
Updated
2021/12/16
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2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Uses

DHMB (2,3-Dihydroxy-4-methoxybenzaldehyde) is a small organic molecule with anti-fungal and anti-inflammatory activity. DHMB has protective effect on intestinal epithelial cells[1].

Synthesis Reference(s)

Synthetic Communications, 16, p. 645, 1986 DOI: 10.1080/00397918608057734

Synthesis

2103-57-3

19283-70-6

4055-69-0

General procedure for the synthesis of 2-hydroxy-3,4-dimethoxybenzaldehyde (29) and 2,3-dihydroxy-4-methoxybenzaldehyde (29') from 2,3,4-trimethoxybenzaldehyde: 2,3,4-trimethoxybenzaldehyde (5.00 g, 25.5 mmol) was dissolved in anhydrous dichloromethane (15 mL) at 0 °C and under nitrogen protection. Anhydrous boron trichloride (28.0 mL, 1.0 M solution in dichloromethane) was added slowly through a dropping funnel and the reaction mixture was stirred at this temperature for 5 hours. Upon completion of the reaction, the reaction was quenched with distilled water (10 mL), the organic phase was separated, and the aqueous phase was extracted with dichloromethane (2 x 25 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure. 2-Hydroxy-3,4-dimethoxybenzaldehyde (29) (3.75 g, 20.6 mmol, 81% yield) was obtained as a white powder, as well as 2,3-dihydroxy-4-methoxybenzaldehyde (29') (0.20 g, 1.2 mmol, 5% yield) as an off-white powder.1H NMR (500 MHz, CDCl3) δ 11.2 (1H, s 2-OH), 9.75 (1H, s, 1-CHO), 7.29 (1H, d, J=9.0Hz, 6-H), 6.61 (1H, d, J=9.0Hz, 5-H), 3.95 (3H, s, 4-OCH3), 3.91 (3H, s, 3-OCH3).13C NMR (126MHz, CDCl3) δ 194.9 (1-CHO), 159.4 (C-4), 155.7 (C-2), 136.2 (C-3), 130.2 (6-CH), 116.6 (C-1), 104.0 (5-CH), 60.8 (3-OCH3), 56.3 (4-OCH3).

References

[1] Bortolus C, et al. A Small Aromatic Compound Has Antifungal Properties and Potential Anti-Inflammatory Effects against Intestinal Inflammation. Int J Mol Sci. 2019 Jan 14;20(2):321. DOI:10.3390/ijms20020321

2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

8-HYDROXY-7-METHOXYCOUMARIN
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2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE Suppliers

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View Lastest Price from 2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Trimetazidine Impurity 15 4055-69-0
Price
US $30.00-20.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-07-30
Career Henan Chemical Co
Product
2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE 4055-69-0
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-08

4055-69-0, 2,3-DIHYDROXY-4-METHOXYBENZALDEHYDERelated Search:

2',3',4'-TRIMETHOXYACETOPHENONE EUPATORIN-5-METHYL ETHER 2,3,4-Trimethoxybenzaldehyde 2,3,4-Trimethoxy-6-methylbenzaldehyde 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE MARITIMEIN 2,3-DIHYDROXY-4-METHOXYBENZOIC ACID 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID 2,3,4-Trimethoxybenzoic acid 3,7,3',4'-TETRAMETHYLGOSSYPETIN 4,5-Dihydroxy-3-methoxybenzaldehyde,3,4-DIHYDROXY-5-METHOXYBENZALDEHYDE 2,3-DIHYDROXY-4-METHOXYACETOPHENONE MELICOPIDINE 2'-HYDROXY-3',4'-DIMETHOXYACETOPHENONE 2,4-DIMETHOXY-3-HYDROXYACETOPHENONE 2,3,4-TRIMETHOXY-6-HYDROXYACETOPHENONE 2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE 3'-ACETOXY-2',4'-DIMETHOXYACETOPHENONE

  • 2,3-DIHYDROXY-4-METHOXYBENZALDEHYDE
  • 4-METHOXY-2,3-DIHYDROXYBENZALDEHYDE 95%
  • 2 3-DIHYDROXY-4-METHOXYBENZALDEHYDE 95%
  • 4-METHOXY-2,3-DIHYDROXYBENZALDEHYDE
  • AKOS 235-08
  • Trimetazidine Impurity 15
  • Benzaldehyde, 2,3-dihydroxy-4-methoxy-
  • Phosphorousacid,tris(1,3-dimethylethyl)ester
  • 4-Piperidinepropanol,8-hydroxy-
  • 4055-69-0
  • Aromatic Aldehydes & Derivatives (substituted)