ChemicalBook > CAS DataBase List > 2-FLUORO-4-FORMYL-BENZONITRILE

2-FLUORO-4-FORMYL-BENZONITRILE

Product Name
2-FLUORO-4-FORMYL-BENZONITRILE
CAS No.
101048-76-4
Chemical Name
2-FLUORO-4-FORMYL-BENZONITRILE
Synonyms
Olaparib Impurity 163;3-Fluoro-4-Cyanobenzaldehyde;4-CYANO-3-FLUOROBENZALDEHYDE;2-FLUORO-4-FORMYL-BENZONITRILE;Benzonitrile, 2-fluoro-4-formyl-;2-Fluoro-4-formylbenzonitrile 98%;2-fluoro-4-formylbenzenecarbonitrile;Benzonitrile, 2-fluoro-4-formyl- (9CI)
CBNumber
CB5200098
Molecular Formula
C8H4FNO
Formula Weight
149.12
MOL File
101048-76-4.mol
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2-FLUORO-4-FORMYL-BENZONITRILE Property

Melting point:
80-84 °C(lit.)
Boiling point:
276.4±25.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
color 
White to off-white
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Safety

Hazard Codes 
Xn,T,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
682454
Product name
4-Cyano-3-fluorobenzaldehyde
Purity
96%
Packaging
500mg
Price
$103
Updated
2023/06/20
TCI Chemical
Product number
F1112
Product name
2-Fluoro-4-formylbenzonitrile
Purity
>97.0%(GC)
Packaging
1g
Price
$91
Updated
2025/07/31
TRC
Product number
F591778
Product name
2-Fluoro-4-formylbenzonitrile
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
F591778
Product name
2-Fluoro-4-formylbenzonitrile
Packaging
500mg
Price
$110
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0019783
Product name
2-FLUORO-4-FORMYLBENZENECARBONITRILE
Purity
95.00%
Packaging
1G
Price
$755.37
Updated
2021/12/16
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2-FLUORO-4-FORMYL-BENZONITRILE Chemical Properties,Usage,Production

Synthesis

222978-02-1

101048-76-4

Example 16b Preparation of 2-fluoro-4-formylbenzonitrile: Pyridinium chlorochromate (7.39 g, 34.27 mmol) was added to a solution of 2-fluoro-4-(hydroxymethyl)benzylcarbonitrile (5.18 g, 34.27 mmol) in methylene chloride (150 mL). The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the mixture was allowed to undergo rapid filtration through a short silica gel pad and the silica gel pad was washed with dichloromethane. The filtrates were combined and concentrated under reduced pressure to give 2-fluoro-4-formylbenzonitrile as a white solid (4.6 g, 90% yield).

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 14, p. 2973 - 2984
[2] Patent: US2008/119457, 2008, A1. Location in patent: Page/Page column 51
[3] Patent: US2003/220241, 2003, A1
[4] Patent: US2003/220241, 2003, A1
[5] Patent: US2003/87940, 2003, A1

2-FLUORO-4-FORMYL-BENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-4-FORMYL-BENZONITRILE Suppliers

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View Lastest Price from 2-FLUORO-4-FORMYL-BENZONITRILE manufacturers

Career Henan Chemical Co
Product
2-FLUORO-4-FORMYL-BENZONITRILE 101048-76-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-30

101048-76-4, 2-FLUORO-4-FORMYL-BENZONITRILERelated Search:

2-FLUORO-4-FORMYL-BENZONITRILE Benzonitrile 4-FLUORO-3-FORMYL-BENZONITRILE 10014 2-FLUORO-5-FORMYL BENZONITRILE,6002 2-FLUORO-5-FORMYL BENZONITRILE 3-FLUORO-4-FORMYL-BENZONITRILE 4-Cyano-3-fluorobenzoic acid Methyl 4-cyano-3-fluorobenzoate ethyl 4-cyano-3-fluorobenzenecarboxylate 4-cyano-2,3,5,6-tetrafluorobenzoic acid 4-CYANO-3,5-DIFLUORO BENZALDEHYDE Benzonitrile, 4-acetyl-2-fluoro- (9CI)

  • 2-FLUORO-4-FORMYL-BENZONITRILE
  • 4-CYANO-3-FLUOROBENZALDEHYDE
  • Benzonitrile, 2-fluoro-4-formyl- (9CI)
  • 2-fluoro-4-formylbenzenecarbonitrile
  • Benzonitrile, 2-fluoro-4-formyl-
  • 2-Fluoro-4-formylbenzonitrile 98%
  • 3-Fluoro-4-Cyanobenzaldehyde
  • Olaparib Impurity 163
  • 101048-76-4
  • Organic Building Blocks
  • Nitrogen Compounds
  • Cyanides/Nitriles
  • Building Blocks
  • C8 to C9
  • NITRILE
  • HALIDE
  • ALDEHYDE