4,6-Dimethyl-2-methylsulfonylpyrimidine
- Product Name
- 4,6-Dimethyl-2-methylsulfonylpyrimidine
- CAS No.
- 35144-22-0
- Chemical Name
- 4,6-Dimethyl-2-methylsulfonylpyrimidine
- Synonyms
- DLMSP;VITAS-BB TBB000242;4,6-Dimethyl-2-methy;Ambrisentan Impurity 6;4,6-Dimethyl-2-(methylsulfonyl;4,6-dimethyl-2-mesyl-pyrimidine;6-DiMethyl-2-MethylsulfonylpyriMidine;4,6-DIMETHY-2-METHYLSULFONYLPYRIMIDINE;4,6-diMethyl-2-Methylsulfonyl pyridine;4,6-DIMETHYL-2-METHYLSULFONYLPYRIMIDINE
- CBNumber
- CB5202360
- Molecular Formula
- C7H10N2O2S
- Formula Weight
- 186.23
- MOL File
- 35144-22-0.mol
4,6-Dimethyl-2-methylsulfonylpyrimidine Property
- Melting point:
- 84-86°C
- Boiling point:
- 358.3±45.0 °C(Predicted)
- Density
- 1.239
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- -1.84±0.30(Predicted)
- form
- Crystalline Solid
- color
- Red-brown
- InChIKey
- ZHPSNGCLCHWTRG-UHFFFAOYSA-N
- CAS DataBase Reference
- 35144-22-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D3699
- Product name
- 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $68
- Updated
- 2025/07/31
- Product number
- D3699
- Product name
- 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $269
- Updated
- 2025/07/31
- Product number
- D446930
- Product name
- 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- APN0000236
- Product name
- 4,6-DIMETHYL-2-METHYL SULFONYL PYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $130.73
- Updated
- 2021/12/16
- Product number
- FD12082
- Product name
- 4,6-Dimethyl-2-methylsulfonylpyrimidine
- Packaging
- 25g
- Price
- $150
- Updated
- 2021/12/16
4,6-Dimethyl-2-methylsulfonylpyrimidine Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
4,6-Dimethyl-2-(methylsulfonyl)pyrimidine is a reactant used in the preparation of [(dimethylpyrimidinyl)oxy]diphenyl butyric acid derivatives as endothelin receptor antagonists.
Synthesis
14001-64-0
35144-22-0
General procedure for the synthesis of 2-methylsulfonyl-4,6-dimethylpyrimidines from 4,6-dimethyl-2-methylthiopyrimidines: 15.9 g (103 mmol) of 4,6-dimethyl-2-methylthiopyrimidines was dissolved in a solvent mixture of 120 mL of dichloromethane and 110 mL of water. Chlorine gas was passed through at 0 °C until the solution took on a yellow color and saturated. Upon completion of the reaction, the solution was purged with nitrogen to remove excess chlorine gas. The organic phase was separated and the aqueous phase was extracted with dichloromethane. The organic phases were combined and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure and the product was crystallized by the addition of ether to give 14 g (73% yield) of 2-methylsulfonyl-4,6-dimethylpyrimidine. The melting point of the product was 79-80 °C. 1H-NMR (270 MHz, CDCl3): δ 7.2 (1H, s), 3.4 (3H, s), 2.6 (6H, s).
References
[1] Patent: US6670367, 2003, B1. Location in patent: Page column 15-16
[2] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 9, p. 2288 - 2300
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 11, p. 2776 - 2795
4,6-Dimethyl-2-methylsulfonylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
4,6-Dimethyl-2-methylsulfonylpyrimidine Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
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- Country
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View Lastest Price from 4,6-Dimethyl-2-methylsulfonylpyrimidine manufacturers
- Product
- 4,6-Dimethyl-2-methylsulfonylpyrimidine 35144-22-0
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-12
- Product
- Ambrisentan Impurity 6 35144-22-0
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95%+
- Supply Ability
- 100000
- Release date
- 2025-03-28
- Product
- 4,6-Dimethyl-2-methylsulfonylpyrimidine 35144-22-0
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25