ISOQUINOLINE-4-CARBONITRILE

Product Name: ISOQUINOLINE-4-CARBONITRILE
CAS No.: 34846-65-6
Chemical Name: ISOQUINOLINE-4-CARBONITRILE
Synonyms: ine-4-carbonitriL;4-Cyanoisoquinoline;4-Isoquinolinecarbonitrile;ISOQUINOLINE-4-CARBONITRILE;4-Cyanoisoquinoline, 4-Cyano-2-azanaphthalene;ISOQUINOLINE-4-CARBONITRILE ISO 9001：2015 REACH
CBNumber: CB5204920
Molecular Formula: C10H6N2
Formula Weight: 154.17
MOL File: 34846-65-6.mol

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ISOQUINOLINE-4-CARBONITRILE Property

Melting point:: 104 °C
Boiling point:: 329.1±15.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 1.96±0.10(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C10H6N2/c11-5-9-7-12-6-8-3-1-2-4-10(8)9/h1-4,6-7H
InChIKey: NPDZTCFGRSYTPF-UHFFFAOYSA-N
SMILES: C1C2=C(C=CC=C2)C(C#N)=CN=1

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: I918273
Product name: Isoquinoline-4-carbonitrile
Packaging: 500mg
Price: $175
Updated: 2021/12/16

Matrix Scientific

Product number: 072287
Product name: Isoquinoline-4-carbonitrile
Purity: 95+%
Packaging: 1g
Price: $462
Updated: 2021/12/16

Apolloscientific

Product number: OR48030
Product name: Isoquinoline-4-carbonitrile
Packaging: 100mg
Price: $73
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-1-8M
Product name: Isoquinoline-4-carbonitrile
Packaging: 100mg
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: W5648
Product name: Isoquinoline-4-carbonitrile
Packaging: 250mg
Price: $87
Updated: 2021/12/16

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ISOQUINOLINE-4-CARBONITRILE Chemical Properties,Usage,Production

Synthesis

557-21-1

34784-02-6

34846-65-6

To a stirred solution of 3-bromoisoquinoline (Intermediate-12) (9.2 g, 44.2 mmol) in N,N-dimethylformamide (DMF) (15 mL) was sequentially added tetrakis(triphenylphosphine)palladium (Pd(PPh3)4) (10.2 g, 8.84 mmol) and zinc cyanide (Zn(CN)2) (10.34 g, 88.44 mmol. 2.0 equiv). The reaction system was degassed with nitrogen (N2) for 20 min to exclude oxygen. Subsequently, the reaction mixture was heated to 120 °C and the reaction was stirred at this temperature overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was cooled to room temperature. Insoluble impurities were removed by filtration and the filtrate was concentrated under reduced pressure to remove solvent. The resulting crude product was purified by fast column chromatography (eluent: 10% ethyl acetate/hexane) to afford the target compound 4-cyanoisoquinoline (3.4 g, 27.4% yield) as a pale yellow solid.

References

[1] Patent: US2013/178457, 2013, A1. Location in patent: Paragraph 0220

ISOQUINOLINE-4-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOQUINOLINE-4-CARBONITRILE Suppliers

China 61 Germany 2 India 3 United Kingdom 2 United States 11 Global 79

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View Lastest Price from ISOQUINOLINE-4-CARBONITRILE manufacturers

Career Henan Chemical Co

Product: ISOQUINOLINE-4-CARBONITRILE 34846-65-6
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%MIN
Supply Ability: ASK
Release date: 2020-01-14

34846-65-6, ISOQUINOLINE-4-CARBONITRILERelated Search:

Isoquinoline-6-carbohydrazide ISOQUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE Isoquinoline-1-carboxylic acid ISOQUINOLINE-1-CARBOTHIOIC ACID AMIDE 1-Isoquinolinecarboxylicacid,hydrazide(9CI) ISOQUINOLINE-5-CARBOTHIOIC ACID AMIDE isoquinoline-4-carbonitrile 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-5-CARBONITRILE HYDROCHLORIDE ISOQUINOLINE-4-CARBONITRILE ISOQUINOLINE-1-CARBONITRILE Isoquinoline-3-carbonitrile,99%,ISOQUINOLINE-3-CARBONITRILE 5-CYANOISOQUINOLINE 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBONITRILE 4-CYANO-3-METHYLISOQUINOLINE 1-AMINO-3-METHYLISOQUINOLINE-4-CARBONITRILE 1-ACETAMIDO-4-CYANO-3-METHYLISOQUINOLINE isoquinoline-6-carbonitrile 11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile

ISOQUINOLINE-4-CARBONITRILE

4-Cyanoisoquinoline, 4-Cyano-2-azanaphthalene

4-Cyanoisoquinoline

4-Isoquinolinecarbonitrile

ine-4-carbonitriL

ISOQUINOLINE-4-CARBONITRILE ISO 9001：2015 REACH

34846-65-6

26947-41-2