ISOQUINOLINE-4-CARBONITRILE
- Product Name
- ISOQUINOLINE-4-CARBONITRILE
- CAS No.
- 34846-65-6
- Chemical Name
- ISOQUINOLINE-4-CARBONITRILE
- Synonyms
- ine-4-carbonitriL;4-Cyanoisoquinoline;4-Isoquinolinecarbonitrile;ISOQUINOLINE-4-CARBONITRILE;4-Cyanoisoquinoline, 4-Cyano-2-azanaphthalene;ISOQUINOLINE-4-CARBONITRILE ISO 9001：2015 REACH
- CBNumber
- CB5204920
- Molecular Formula
- C10H6N2
- Formula Weight
- 154.17
- MOL File
- 34846-65-6.mol
ISOQUINOLINE-4-CARBONITRILE Property
- Melting point:
- 104 °C
- Boiling point:
- 329.1±15.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 1.96±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C10H6N2/c11-5-9-7-12-6-8-3-1-2-4-10(8)9/h1-4,6-7H
- InChIKey
- NPDZTCFGRSYTPF-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=CC=C2)C(C#N)=CN=1
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- I918273
- Product name
- Isoquinoline-4-carbonitrile
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- OR48030
- Product name
- Isoquinoline-4-carbonitrile
- Packaging
- 100mg
- Price
- $73
- Updated
- 2021/12/16
- Product number
- 3H37-1-8M
- Product name
- Isoquinoline-4-carbonitrile
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- W5648
- Product name
- Isoquinoline-4-carbonitrile
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- OR48030
- Product name
- Isoquinoline-4-carbonitrile
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
ISOQUINOLINE-4-CARBONITRILE Chemical Properties,Usage,Production
Synthesis
557-21-1
34784-02-6
34846-65-6
To a stirred solution of 3-bromoisoquinoline (Intermediate-12) (9.2 g, 44.2 mmol) in N,N-dimethylformamide (DMF) (15 mL) was sequentially added tetrakis(triphenylphosphine)palladium (Pd(PPh3)4) (10.2 g, 8.84 mmol) and zinc cyanide (Zn(CN)2) (10.34 g, 88.44 mmol. 2.0 equiv). The reaction system was degassed with nitrogen (N2) for 20 min to exclude oxygen. Subsequently, the reaction mixture was heated to 120 °C and the reaction was stirred at this temperature overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was cooled to room temperature. Insoluble impurities were removed by filtration and the filtrate was concentrated under reduced pressure to remove solvent. The resulting crude product was purified by fast column chromatography (eluent: 10% ethyl acetate/hexane) to afford the target compound 4-cyanoisoquinoline (3.4 g, 27.4% yield) as a pale yellow solid.
References
[1] Patent: US2013/178457, 2013, A1. Location in patent: Paragraph 0220
ISOQUINOLINE-4-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
ISOQUINOLINE-4-CARBONITRILE Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@chemsworth.com
- Country
- India
- ProdList
- 6700
- Advantage
- 30
View Lastest Price from ISOQUINOLINE-4-CARBONITRILE manufacturers
- Product
- ISOQUINOLINE-4-CARBONITRILE 34846-65-6
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-14