ChemicalBook > CAS DataBase List > IMIDAZOLE HYDROCHLORIDE

IMIDAZOLE HYDROCHLORIDE

Product Name
IMIDAZOLE HYDROCHLORIDE
CAS No.
1467-16-9
Chemical Name
IMIDAZOLE HYDROCHLORIDE
Synonyms
Imidazolium chloride;1H-iMidazole hydrochloride;AMerican CustoM CheMicals Corporation;ImidazoleHCl;Imidazole salt;Imidazole-HCl 98%;midazole hydrochloride;IMIDAZOLE HYDROCHLORIDE;GLYOXALINE, HYDROCHLORIDE;Imidazole hydrochloride 99%
CBNumber
CB5212747
Molecular Formula
C3H5ClN2
Formula Weight
104.54
MOL File
1467-16-9.mol
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IMIDAZOLE HYDROCHLORIDE Property

Melting point:
158-161 °C(lit.)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
H2O: 50 mg/mL, clear, colorless
form 
solid
color 
Pale yellow
PH
9.0-10.0
BRN 
3678283
Stability:
Stable. Hygroscopic. Incompatible with strong oxidizing agents.
InChI
InChI=1S/C3H4N2.ClH/c1-2-5-3-4-1;/h1-3H,(H,4,5);1H
InChIKey
JDIIGWSSTNUWGK-UHFFFAOYSA-N
SMILES
C1NC=NC=1.Cl
CAS DataBase Reference
1467-16-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
26-36
WGK Germany 
3
F 
3-10
HS Code 
2933299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I3386
Product name
Imidazole hydrochloride
Packaging
100g
Price
$58.2
Updated
2025/07/31
Sigma-Aldrich
Product number
I3386
Product name
Imidazole hydrochloride
Packaging
500g
Price
$179
Updated
2025/07/31
TRC
Product number
I387618
Product name
Imidazole hydrochloride
Packaging
500mg
Price
$60
Updated
2021/12/16
TRC
Product number
I387618
Product name
Imidazole hydrochloride
Packaging
2.5g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
093771
Product name
1H-Imidazole hydrochloride
Purity
95+%
Packaging
5g
Price
$10
Updated
2021/12/16
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IMIDAZOLE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

Imidazole hydrochloride is a useful research chemical.

Uses

Imidazole hydrochloride has been used:

  • in double immunohistochemistry
  • to determine the activity of octopine dehydrogenase (ODH) in Mytilus galloprovincialis
  • to study the cytoskeletal features during in vitro fertilization after intracytoplasmic sperm injection (ICSI) among humans
  • as a reagent in the synthesis of a probe for monitoring herpes simplex virus type 1 thymidine kinase (HSV1-tk) reporter gene expression in rodents

Synthesis

288-32-4

75-44-5

1467-16-9

530-62-1

In a flask, 68.22 g of imidazole was suspended in 505 g of xylene. The mixture was heated to reflux and 5 g of the xylene/water azeotropic mixture was removed by distillation to achieve dehydration. Subsequently, the temperature of the reaction system was lowered to 66°C and 25.2 grams of phosgene was added dropwise at a rate of 50.4 grams/hour over 30 minutes. After about 15 minutes, the viscosity of the reaction mixture increased significantly, exhibiting a chewing gum-like consistency. During the phosgene dropwise addition, the by-product imidazole hydrochloride precipitated in the form of yellow globules. After maintaining this temperature and continuing stirring for 1 hour, the reaction temperature was raised to 130 °C, at which time the imidazole hydrochloride transformed into a brown molten state. The melt was discharged from the reaction system at 130°C and solidified to a dark green solid upon cooling. The supernatant xylene phase was cooled to 0 °C, the precipitated crystals were filtered and dried at 20 mbar and 50 °C. A white crystalline N,N'-carbonyl diimidazole with a small amount of black impurities (Hazen color number: 489) was finally obtained with a purity of 96.8%, corresponding to 70% of the theoretical yield.

References

[1] Patent: US2005/272937, 2005, A1. Location in patent: Page/Page column 4
[2] Patent: US2005/272937, 2005, A1. Location in patent: Page/Page column 4
[3] Patent: US2005/272937, 2005, A1. Location in patent: Page/Page column 3-4; 5

IMIDAZOLE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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IMIDAZOLE HYDROCHLORIDE Suppliers

China 155 France 1 Germany 2 India 5 South Korea 1 Switzerland 1 United Kingdom 5 United States 24 Global 194
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View Lastest Price from IMIDAZOLE HYDROCHLORIDE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
IMIDAZOLE HYDROCHLORIDE 1467-16-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
IMIDAZOLE HYDROCHLORIDE 1467-16-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
IMIDAZOLE HYDROCHLORIDE 1467-16-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

1467-16-9, IMIDAZOLE HYDROCHLORIDERelated Search:

1H-Imidazole-4-carbaldehyde Imidazole Imidazo[1,2-a]pyridine-7-carboxylic acid (9CI) Imidazo[1,2-b]pyridazine imidazo[1,2-a]pyridin-7-amine hydrobromide Imidazo[1,2-a]pyridine IMIDAZOLE SODIUM DERIVATIVE Imidazolidine 4,5-Dichloroimidazole 2-Chloroadenosine 2-Chloromethylbenzimidazole 4-Methyl-5-imidazolemethanol hydrochloride IMIDAZOLE HYDROCHLORIDE 4-(HYDROXYMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE,4-(HYDROXYMETHYL)IMIDAZOLE HYDROCHLORIDE D(+)-HISTIDINOL DIHYDROCHLORIDE 8-Chlorotheophylline 4,5-DIHYDRO-2-(1-NAPHTHYLMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE 4,5-DIHYDRO-2-(1-NAPHTHYLMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE

  • 1h-imidazole,monohydrochloride
  • GLYOXALINE, HYDROCHLORIDE
  • IMIDAZOLE HYDROCHLORIDE
  • 1,3-DIAZA-2,4-CYCLOPENTADIENE HYDROCHLORIDE
  • ImidazoleHCl
  • 1H-iMidazole hydrochloride
  • Imidazolium chloride
  • AMerican CustoM CheMicals Corporation
  • 1H-IMidazole,hydrochloride (1:1)
  • Imidazole hydrochloride≥ 99% (Titration)
  • midazole hydrochloride
  • Imidazole hydrochloride 99%
  • Imidazole salt
  • Imidazole hydrochloride, 97%
  • Imidazole-HCl 98%
  • 1467-16-9
  • C3H4N2HCl
  • C3H5ClN2
  • C3H4N2ClH
  • Building Blocks
  • Imidazoles
  • Heterocyclic Building Blocks
  • Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines
  • Building Blocks
  • Heterocyclic Building Blocks
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  • Biological Buffers
  • Buffers A to Z