4-Chloro-6-methoxy-2-(methylthio)pyrimidine

Product Name: 4-Chloro-6-methoxy-2-(methylthio)pyrimidine
CAS No.: 89466-42-2
Chemical Name: 4-Chloro-6-methoxy-2-(methylthio)pyrimidine
Synonyms: 4-Chloro-6-methoxy-2-(methylthio);6-methoxy-2-methylthio-4-chlorpyrimidine;4-CHLORO-6-METHOXY-2-(METHYLTHIO)PYRIMIDINE;Pyrimidine, 4-chloro-6-methoxy-2-(methylthio)-;4-Chloro-6-methoxy-2-(methylthio)pyrimidine ,98%
CBNumber: CB52129407
Molecular Formula: C6H7ClN2OS
Formula Weight: 190.65
MOL File: 89466-42-2.mol

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4-Chloro-6-methoxy-2-(methylthio)pyrimidine Property

Melting point:: 38-39℃
Boiling point:: 288℃
Density: 1.36
refractive index: 1.
Flash point:: 128℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -2.26±0.30(Predicted)
Appearance: white solid
InChI: InChI=1S/C6H7ClN2OS/c1-10-5-3-4(7)8-6(9-5)11-2/h3H,1-2H3
InChIKey: FNYLFWGITLMOHA-UHFFFAOYSA-N
SMILES: C1(SC)=NC(OC)=CC(Cl)=N1

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Safety

Risk Statements: 22
Safety Statements: 36/37
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC154020
Product name: 4-Chloro-6-methoxy-2-(methylthio)pyrimidine ,98%
Packaging: 50mg
Price: $66
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC154020
Product name: 4-Chloro-6-methoxy-2-(methylthio)pyrimidine ,98%
Packaging: 100mg
Price: $114
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC154020
Product name: 4-Chloro-6-methoxy-2-(methylthio)pyrimidine ,98%
Packaging: 250mg
Price: $227.5
Updated: 2021/12/16

AK Scientific

Product number: Z2860
Product name: 4-Chloro-6-methoxy-2-methylsulfanylpyrimidine
Packaging: 1g
Price: $237
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC154020
Product name: 4-Chloro-6-methoxy-2-(methylthio)pyrimidine ,98%
Packaging: 500mg
Price: $395
Updated: 2021/12/16

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4-Chloro-6-methoxy-2-(methylthio)pyrimidine Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

4-chloro-6-methoxy-2-(methylthio)pyrimidine is a versatile scaffold and can undergo Suzuki-Miyaura coupling to afford 4-aryl-6-methoxy-2-(methylthio)pyrimidines, as well as amine or alcohol displacement of the chloride, oxidation to sulfone, and condensation reactions to give polycyclic systems][1].

Synthesis

67-56-1

6299-25-8

89466-42-2

To a reaction vial containing an ethanol solution (20 mL) of sodium (0.28 g, 12 mmol) was added 4,6-dichloro-2-(methylthio)pyrimidine (1.95 g, 10 mmol) and stirred at room temperature until the reaction was complete, the progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the solvent was removed by evaporation under reduced pressure and quenched by addition of water. Subsequently extracted with dichloromethane (CH2Cl2), the organic phase was washed with water and dried with anhydrous sodium sulfate (Na2SO4). The organic phase was concentrated under reduced pressure and the residue was recrystallized with ether to afford the target compound 6-methoxy-2-methylthio-4-chloropyrimidine (4 g) as a white solid in 70% yield with a melting point of 39-40°C. IR spectra (KBr, cm-1 ): 3003, 2939, 1544, 1328, 1274, 1505, 1030, 820. NMR hydrogen spectra ( 1H NMR, 400 MHz, CDCl3) δ: 2.55 (s, 3H, SCH3), 3.97 (s, 3H, OCH3), 6.41 (s, 1H, pyrimidine-H). Nuclear magnetic resonance carbon spectrum (13C NMR, 100 MHz, CDCl3): δ14.29, 54.52, 102.43, 160.34, 169.90, 172.92. liquid chromatography-mass spectrometry (LC-MS, m/z): 190.0. calculated elemental analysis values (C6H7ClN2OS): C, 37.80; H, 3.70; N 14.69. Measured values: C, 37.72; H, 3.75; N, 14.78.

References

[1] A. Kalogirou, P. Koutentis. “4-Chloro-6-ethoxy-2-(methylthio)pyrimidine.” Molbank 2017 1 (2016).

4-Chloro-6-methoxy-2-(methylthio)pyrimidine Preparation Products And Raw materials

Raw materials

Sodium Phosphorus oxitrichloride Methanol Diethyl malonate Thiourea Dimethyl sulfate

Preparation Products

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4-Chloro-6-methoxy-2-(methylthio)pyrimidine Suppliers

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View Lastest Price from 4-Chloro-6-methoxy-2-(methylthio)pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Chloro-6-Methoxy-2-Methylsulfanyl-pyriMidine 89466-42-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

89466-42-2, 4-Chloro-6-methoxy-2-(methylthio)pyrimidineRelated Search:

Propylthiouracil 4-Chloropyrimidine 4-Chloro-2-methylthiopyrimidine 6-CHLORO-4-ETHOXY-2-METHYLMERCAPTOPYRIMIDINE 4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE 4-Chloro-6-methoxy-2-(methylthio)pyrimidine

4-Chloro-6-methoxy-2-(methylthio)pyrimidine ,98%

4-CHLORO-6-METHOXY-2-(METHYLTHIO)PYRIMIDINE

4-Chloro-6-methoxy-2-(methylthio)

Pyrimidine, 4-chloro-6-methoxy-2-(methylthio)-

6-methoxy-2-methylthio-4-chlorpyrimidine

89466-42-2