3-(4-Methylbenzoyl)propionic acid
- Product Name
- 3-(4-Methylbenzoyl)propionic acid
- CAS No.
- 4619-20-9
- Chemical Name
- 3-(4-Methylbenzoyl)propionic acid
- Synonyms
- AURORA 7994;AKOS BB-9554;AKOS BBS-00003761;Zolpidem Impurity 11;Zolpidem EP Impurity C;Tolyoyl Propionic acid;Tolyloyl Propionic Acid;Methylbenzoylpropionicacid;3-(P-TOLUOYL)PROPIONIC ACID;4-OXO-4-P-TOLYL-BUTYRIC ACID
- CBNumber
- CB5214064
- Molecular Formula
- C11H12O3
- Formula Weight
- 192.21
- MOL File
- 4619-20-9.mol
3-(4-Methylbenzoyl)propionic acid Property
- Melting point:
- 127-130 °C(lit.)
- Boiling point:
- 288.19°C (rough estimate)
- Density
- 1.1430 (rough estimate)
- refractive index
- 1.5340 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 4.57±0.17(Predicted)
- color
- White to Almost white
- Water Solubility
- insoluble
- BRN
- 2099653
- CAS DataBase Reference
- 4619-20-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 442941
- Product name
- 4-(4-Methylphenyl)-4-oxobutyric acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $71
- Updated
- 2023/06/20
- Product number
- M1377
- Product name
- 4-(4-Methylphenyl)-4-oxobutyric Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- M1377
- Product name
- 4-(4-Methylphenyl)-4-oxobutyric Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $209
- Updated
- 2025/07/31
- Product number
- B399940
- Product name
- 4-(4-Methylphenyl)-4-oxobutanoicAcid
- Packaging
- 10g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- IM57803
- Product name
- 3-(4-Methylbenzoyl)propionic acid
- Packaging
- 5G
- Price
- $50
- Updated
- 2021/12/16
3-(4-Methylbenzoyl)propionic acid Chemical Properties,Usage,Production
Chemical Properties
White to light beige crystalline powder
Uses
3-(4-Methylbenzoyl)propionic acid can be used as an intermediate in agrochemical, pharmaceutical and dyestuff field
General Description
4-(4-Methylphenyl)-4-oxobutyric acid is an organic building block. It is a commercial corrosion inhibitor.
Synthesis
108-30-5
108-88-3
4619-20-9
The general procedure for the synthesis of 3-(4-methylbenzoyl)propionic acid from succinic anhydride and toluene was as follows: 75.7 g of succinic anhydride was dissolved in 457.5 mL of toluene. Under stirring, 220.5 g of anhydrous aluminum trichloride (AlCl3) was added in batches. The temperature of the reaction mixture was maintained in the range of 50-60 °C. After 2 hours of reaction, the completion of the reaction was monitored by thin layer chromatography (TLC). The reaction mixture was slowly added dropwise to 1250 mL of 1 mol/L ice hydrochloric acid under vigorous stirring. During the dropwise addition, milky solids were gradually precipitated. After completion of the dropwise addition, the mixture was continued to be stirred for 0.5 h, followed by filtration. The filter cake was washed sequentially with toluene and ice water and then pumped with 50 mL of ethyl acetate. The resulting solution was slowly added to 500 mL of petroleum ether to induce crystallization. After stirring for 0.5 h, the crystals were collected by filtration and dried at 40 °C for 2 h to give 144 g of Compound II (intermediate) in 99.3% yield. [Compound II intermediate] was a white solid.
References
[1] Organic Letters, 2016, vol. 18, # 3, p. 504 - 507
[2] Patent: CN107628947, 2018, A. Location in patent: Paragraph 0053; 0054; 0055; 0056; 0057
[3] Russian Journal of General Chemistry, 2014, vol. 84, # 9, p. 1825 - 1829
[4] Zhurnal Obshchei Khimii, 2014, vol. 84, # 9, p. 1825 - 1829,5
[5] Molecules, 2018, vol. 23, # 3,
3-(4-Methylbenzoyl)propionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-(4-Methylbenzoyl)propionic acid Suppliers
- Tel
- +86 943-8535351 13389336721
- Fax
- +86-943-8535351
- sales@chengzechem.com
- Country
- China
- ProdList
- 289
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
View Lastest Price from 3-(4-Methylbenzoyl)propionic acid manufacturers
- Product
- 3-(4-Methylbenzoyl)propionic acid 4619-20-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-04-18
- Product
- 3-(4-Methylbenzoyl)propionic acid 4619-20-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-09