ChemicalBook > CAS DataBase List > 2-Aminothiazole

2-Aminothiazole

Product Name
2-Aminothiazole
CAS No.
96-50-4
Chemical Name
2-Aminothiazole
Synonyms
Aminothiazole;1,3-Thiazol-2-amine;aminothiazol;2-THIAZOLAMINE;Abadol;cp1585;BASEDOL;RP 2921;ABADOLE;AKOS 204-05
CBNumber
CB5215834
Molecular Formula
C3H4N2S
Formula Weight
100.14
MOL File
96-50-4.mol
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2-Aminothiazole Property

Melting point:
91-93 °C (lit.)
Boiling point:
117 °C (15.002 mmHg)
Density 
1.241 (estimate)
vapor pressure 
<1 hPa (20 °C)
refractive index 
1.5300 (estimate)
Flash point:
117°C/15mm
storage temp. 
Store below +30°C.
solubility 
1 M HCl: soluble50mg/mL, clear (dark yellow-brown)
pka
5.36(at 20℃)
form 
Crystalline Powder, Grains, Lumps or Flakes
color 
Brown
PH
9.6 (100g/l, H2O, 20℃)
Water Solubility 
100 g/L (20 ºC)
Merck 
14,479
BRN 
105738
InChIKey
RAIPHJJURHTUIC-UHFFFAOYSA-N
LogP
0.380
CAS DataBase Reference
96-50-4(CAS DataBase Reference)
NIST Chemistry Reference
2-Aminothiazole(96-50-4)
EPA Substance Registry System
2-Aminothiazole (96-50-4)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36-36/37-20/21/22
Safety Statements 
26-36/37-39-36
WGK Germany 
3
RTECS 
XJ2100000
F 
8-9
Autoignition Temperature
600 °C
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29341000
Toxicity
LD50 orally in Rabbit: 480 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.01272
Product name
2-Aminothiazole
Purity
for synthesis
Packaging
100g
Price
$41.9
Updated
2024/03/01
Sigma-Aldrich
Product number
123129
Product name
2-Aminothiazole
Purity
97%
Packaging
5g
Price
$30.1
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01272
Product name
2-Aminothiazole
Purity
for synthesis
Packaging
500g
Price
$152
Updated
2024/03/01
Sigma-Aldrich
Product number
123129
Product name
2-Aminothiazole
Purity
97%
Packaging
100g
Price
$57.1
Updated
2024/03/01
TCI Chemical
Product number
A0633
Product name
2-Aminothiazole
Purity
>98.0%(T)
Packaging
25g
Price
$22
Updated
2024/03/01
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2-Aminothiazole Chemical Properties,Usage,Production

Chemical Properties

brown crystalline powder, grains, lumps or flakes

Uses

antithyroid agent

Uses

Usually used in the synthesis of 2-aminothiazole-modified silica gel，and aslo used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation.

Uses

2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds.

Definition

ChEBI: A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2.

Synthesis Reference(s)

Journal of the American Chemical Society, 76, p. 693, 1954 DOI: 10.1021/ja01632a016

General Description

Light brown crystals or brown granular solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2-Aminothiazole reacts violently when nitrated with nitric or nitric-sulfuric acids. 2-Aminothiazole is also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides.

Fire Hazard

Flash point data for 2-Aminothiazole are not available; however, 2-Aminothiazole is probably combustible.

Biochem/physiol Actions

2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders.

Safety Profile

Poison by ingestion andintraperitoneal routes. Mutation data reported.Spontaneous ignition occurs at 100°. Mixtures with nitricacid or nitric acid + sulfuric acid explode on heating.Incompatible with HNO3 and H2SO4. When heated todecomposition it emi

Purification Methods

It crystallises from pet ether (b 100-120o), or EtOH. [Beilstein 27 III/IV 4574.]

2-Aminothiazole Preparation Products And Raw materials

Raw materials

Chloroacetaldehyde Thiourea

Preparation Products

2-CHLORO-5-NITROTHIAZOLE ethyl 2-(2-aminothiazol-5-ylthio)acetate 2-Amino-((1-carboxy-1-methyl ethoxy)imino)-4-thiazoleacetic acid Cationic Violet 3BL 3-(-Hydroxyphenethyl)-2-imino thiazolidine BASIC RED 29 1,3-Thiazole-2-carbaldehyde 2-Amino-5-nitrothiazole 2-Amino-5-bromothiazole monohydrobromide
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2-Aminothiazole Suppliers

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View Lastest Price from 2-Aminothiazole manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-Aminothiazole 96-50-4
Price
US $58.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-22
Jinan Finer Chemical Co., Ltd
Product
2-Aminothiazole 96-50-4
Price
US $0.00/Kg/Drum
Min. Order
1ASSAYS
Purity
99%
Supply Ability
200mt/year
Release date
2021-07-08
Baoji Guokang Bio-Technology Co., Ltd.
Product
2-Aminothiazole 96-50-4
Price
US $75.00/Kg/Bag
Min. Order
1KG
Purity
98%
Supply Ability
10T
Release date
2021-06-03

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