Kaempferol 3-arabinofuranoside

Product Name: Kaempferol 3-arabinofuranoside
CAS No.: 5041-67-8
Chemical Name: Kaempferol 3-arabinofuranoside
Synonyms: Juglanin;Juglanin【Juglans】;Kaempferol 3-arabinoside;Kaempferol 3-arabinofuranoside;Kaempferol 3-O-alpha-L-arabinofuranoside;3-[(α-L-Arabinofuranosyl)oxy]-4',5,7-trihydroxyflavone;3-(α-L-Arabinofuranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one,3-(a-L-arabinofuranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-;4H-1-Benzopyran-4-one, 3-(α-L-arabinofuranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
CBNumber: CB52171921
Molecular Formula: C20H18O10
Formula Weight: 418.35
MOL File: 5041-67-8.mol

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Kaempferol 3-arabinofuranoside Property

Melting point:: 230-231℃ (ethanol )
Boiling point:: 803.5±65.0 °C(Predicted)
Density: 1.76±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Methanol : 16.67 mg/mL (39.85 mM)
form: Solid
pka: 6.20±0.40(Predicted)
color: White to yellow
InChI: InChI=1/C20H18O10/c21-7-13-15(25)17(27)20(29-13)30-19-16(26)14-11(24)5-10(23)6-12(14)28-18(19)8-1-3-9(22)4-2-8/h1-6,13,15,17,20-25,27H,7H2/t13-,15-,17+,20?/s3
InChIKey: POQICXMTUPVZMX-XQAOVFCONA-N
SMILES: C1(C2=CC=C(O)C=C2)OC2=C(C(=CC(=C2)O)O)C(=O)C=1OC1O[C@H](CO)[C@@H](O)[C@@H]1O |&1:23,26,28,r|

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: J211005
Product name: Juglanin
Packaging: 1mg
Price: $450
Updated: 2021/12/16

Apolloscientific

Product number: BISN0301
Product name: Juglanin
Packaging: 1mg
Price: $580
Updated: 2021/12/16

ChemScene

Product number: CS-7981
Product name: Juglanin
Purity: >98.0%
Packaging: 5mg
Price: $1188
Updated: 2021/12/16

Arctom

Product number: AS474050
Product name: Juglanin
Packaging: 1g
Price: $187
Updated: 2021/12/16

Arctom

Product number: CFN96238
Product name: Juglanin
Purity: ≥98%
Packaging: 5mg
Price: $318
Updated: 2021/12/16

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Kaempferol 3-arabinofuranoside Chemical Properties,Usage,Production

Uses

Juglanin inhibits the proliferation of breast cancer cell in a dose- and time-dependent manner and presents less cytotoxic against the normal cells. It is a JNK activator.

Definition

ChEBI: Kaempferol 3-arabinofuranoside is a member of flavonoids and a glycoside.

in vivo

Juglanin (10-20 mg/kg, i.p., daily, 7 days) inhibits growth of human breast cancer xenograft in a tumor-transplanted mouse model^[1].
Juglanin (10-30 mg/kg, i.p., 5 times weekly) ameliorates neuroinflammation-related memory impairment and neurodegeneration through impeding TLR4/NF-κB in C57BL6 male mice^[2].
Juglanin (80 mg/kg, i.g., daily, 21 days) protects against bleomycin (BLM, HY-108345)-induced lung injury by inhibiting fibrosis in C57BL/6 male mice^[3].

Animal Model:	Tumor-transplanted mouse model ^[1]
Dosage:	10-20 mg/kg
Administration:	Intraperitoneal injection (i.p.), daily, 7 days
Result:	Increased levels of cleaved Caspase-9 and Caspase-3, LC3BI, LC3BII and phosphorylated JNK. Increased dead cells and apoptosis proportion in juglanin-treated tumor tissues. Increase in mean areas that stained positively cleaved Caspase-3 in juglanin-treated tumor tissues.

Animal Model:	C57BL6 male mice^[2]
Dosage:	10-30 mg/kg
Administration:	Intraperitoneal injection (i.p.), 5 times weekly
Result:	Increased number of platform crossings and expanded time in target quadrant. Decreased the expression level of α-synuclein, pro-inflammatory cytokines (IL-1β, TNF-α, IL-18 and COX-2), TLR-4, MyD88, CD14, Aβ, phosphorylation of Tau, Ibal and neurotrophic factor (BDNF). Reversed LPS-triggered effect on synaptic markers, up-regulating the expression of SYP, PSD-95 and SNAP-25. Restored TH levels in the hippocampus of mice in a dose-dependent manner. Decreased p-IKKα, p-IκBα and p-NF-κB levels combinated with LPS. Decreased the GFAP-positive cells.

Animal Model:	C57BL/6 male mice^[3]
Dosage:	80 mg/kg
Administration:	i.g., daily, 1-21 days
Result:	Improved the survial rate of the BLM (HY-108345)-treated mice. Decreased the expression of BALF, CXCL1, IL-6, TNF-α, MPO activity, TGF-β1, and its down-streaming proteins (fibronectin/MMP-9/α-SMA/collagen I) Reduced the number of total cells, neutrophils and macrophages in BALF.

IC 50

JNK

Kaempferol 3-arabinofuranoside Preparation Products And Raw materials

Raw materials

Preparation Products

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Kaempferol 3-arabinofuranoside Suppliers

China 98 United States 6 Global 104

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View Lastest Price from Kaempferol 3-arabinofuranoside manufacturers

Career Henan Chemica Co

Product: Kaempferol 3-arabinofuranoside 5041-67-8
Price: US $1.30/g
Min. Order: 1g
Purity: 98%
Supply Ability: 10kg
Release date: 2020-10-27

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Juglanin

Juglanin【Juglans】

Kaempferol 3-arabinofuranoside

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Kaempferol 3-arabinoside

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5041-67-8