Kaempferol

ChemicalBook > CAS DataBase List > Kaempferol

Pharmacological effects Mechanism of action Bioactivity

Product Name: Kaempferol
CAS No.: 520-18-3
Chemical Name: Kaempferol
Synonyms: ASARONE;kaempherol;kempferol;KAEMPFEROL 98%;3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chroMen-4-one;campherol;pelargidenolon;Kaempferol Hydrate;3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one;3,4'
CBNumber: CB5223176
Molecular Formula: C15H10O6
Formula Weight: 286.24
MOL File: 520-18-3.mol

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Kaempferol Property

Melting point:: 276°C
Boiling point:: 348.61°C (rough estimate)
Density: 1.2981 (rough estimate)
refractive index: 1.4413 (estimate)
storage temp.: 2-8°C
solubility: ethanol: 20 mg/mL
form: powder
Colour Index: 75640
pka: 6.34±0.40(Predicted)
color: yellow
Merck: 14,5274
BRN: 304401
Stability:: Unstable in Solution
InChIKey: IYRMWMYZSQPJKC-UHFFFAOYSA-N
LogP: 2.685 (est)
CAS DataBase Reference: 520-18-3(CAS DataBase Reference)
IARC: 3 (Vol. 31, Sup 7) 1987

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38-68-25
Safety Statements: 26-36-45-36/37-36/37/38-22
RIDADR: 2811
WGK Germany: -
RTECS: LK9275200
F: 8-10-23
HS Code: 29329990
Hazardous Substances Data: 520-18-3(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2705
Product name: Kaempferol
Purity: Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 30?mg
Packaging: 30MG
Price: $400
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89235
Product name: Kaempferol
Purity: phyproof? Reference Substance
Packaging: 20MG
Price: $423
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1354900
Product name: Kaempferol
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 15mg
Price: $429
Updated: 2024/03/01

Sigma-Aldrich

Product number: 00550580
Product name: Kaempferol
Purity: primary reference standard
Packaging: 10mg
Price: $497
Updated: 2023/01/07

TCI Chemical

Product number: K0018
Product name: Kaempferol Hydrate
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $974
Updated: 2024/03/01

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Kaempferol Chemical Properties,Usage,Production

Pharmacological effects

Kaempferol (3,5,7‐trihydroxy‐2‐[4‐hydroxyphenyl]‐4H‐1‐benzopyran‐4‐one) is a yellow bioactive flavonoid, which is present inmany edible plants such as tea, cabbage, broccoli, endive, kale, beans, tomato, strawberries, leek, and grapes. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Its efficacy, a broad range of activity, and low toxicity compared with other examined compounds, make it an attractive chemical in the fight against diseases (including cancer).

Mechanism of action

Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3‐kinase (PI3K)/AKT (protein kinase B) and human T‐cell leukemia/lymphoma virus‐I (HTLV-I) signaling pathways, suppresses protein expression of epithelial‐mesenchymal transition (EMT)‐related markers including N‐cadherin, E‐cadherin, Slug, and Snail, and metastasis‐related markers such as matrix metallopeptidase 2 (MMP-2).

Bioactivity

As an anti‐oxidant, kaempferol counteracts production of superoxide ions and lowers the formation of reactive oxygen and nitrogen species. It also scavenges Fenton‐generated hydroxyl radical, peroxynitrite, and hydroxyl radicals. Furthermore, kaempferol suppresses the activity of xanthine oxidase and enhances the activities of catalase, heme oxygenase‐1, and superoxide dismutase.

Chemical Properties

Yellow Solid

Uses

antidepressant, inhibits fatty acid amide hydrolase

Uses

Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.

Uses

Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range.

Definition

ChEBI: Kaempferol is a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment. It has a role as an antibacterial agent, a plant metabolite, a human xenobiotic metabolite, a human urinary metabolite, a human blood serum metabolite and a geroprotector. It is a member of flavonols, a 7-hydroxyflavonol and a tetrahydroxyflavone. It is a conjugate acid of a kaempferol oxoanion.

General Description

Kaempferol is a polyphenolic antioxidant abundantly present in vegetables and fruits. It has a diphenylpropane structure. In many plants, it is present as a glycosidic form namely, kaempferol-3-O-glucoside.

Biological Activity

Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca 2+ uniporter (EC 50 = 7 μ M). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro .

Biochem/physiol Actions

Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.

Anticancer Research

Kaempferol is one of the secondary metabolites found in some plants, plant-derivedfoods, and traditional medicines. It is a flavonoid compound obtained from someedible plants including grapes, tea, strawberries, broccoli, tomato, cabbage, leek,kale, endive, and beans. It inhibits growth and migration of pancreatic cancer cellsby acting on proto-oncogene tyrosine kinase (Src), ERK1/2, and AKT pathways(Singh et al. 2016a). It is being investigated in pancreatic and lung cancers toevaluate its antiangiogenic, anticancer, and radical scavenging activities. It showsmoderate cytostatic activity in PC3, HeLa, and K562 human cancer cells. It isidentified as aryl hydrocarbon receptor antagonist and acts against ABCG2 (ATP-bindingcassette subfamily G member 2)-mediated multidrug resistance bypreventing the ABCG2 upregulation in esophageal carcinoma. It induces theapoptosis of ovarian cancer cell by activating p53 in intrinsic pathway mechanism.It is an inhibitor of breast cancer resistance protein (BCRP), quinine reductase-2,and a substrate of BCRP (Calderon-Montano et al. 2011; Wang et al. 2012).

storage

Store at +4°C

Kaempferol Preparation Products And Raw materials

Raw materials

Preparation Products

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Kaempferol Suppliers

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View Lastest Price from Kaempferol manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: Kaempferol 520-18-3
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2024-01-05

Wuhan Haorong Biotechnology Co.,Ltd

Product: Kaempferol 520-18-3
Price: US $0.00-0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 200000
Release date: 2023-08-15

BINBO BIOLOGICAL CO.,LTD

Product: Kaempferol 520-18-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000 kg
Release date: 2024-04-22

520-18-3, KaempferolRelated Search:

ARTEMISININ FLAVONE 7-HYDROXYFLAVONE Isoflavone Hydroxy silicone oil Chrysin KAEMPFERITRIN KAEMPFEROL-3-O-RUTINOSIDE,KAEMPFEROL-3-RUTINOSIDE Rotundine Quercetin dihydrate Sophoricoside Kaempferol 3-neohesperidoside 7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-3,5-dihydroxy-2-(4-hydroxyphenyl)-4H-benzopyran-4-one kaempferol-3-O-galactoside KaeMpferol-4'-O-β-D-glucopyranoside KaeMpferol 7-O-rhaMnoside KAEMPFEROL-3-GLUCURONIDE Kaempferol-3-O-(2,6-di-O-trans-p-coumaroyl)-beta-D-glucopyranoside

3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on

5,7,4’-trihydroxyflavonol

c.i.75640

campherol

indigoyellow

kaempherol

kampherol

kempferol

nimbecetin

pelargidenolon

pelargidenolon1497

populnetin

rhamnolutein

rhamnolutin

swartziol

ASARONE

KAEMPFEROL

3,5,7,4'-TETRAHYDROXYFLAVONE

3,5,7-TRIHYDROXY-2-[4-HYDROXY-PHENYL]-4H-1-BENZOPYRAN-4-ONE

3,4',5,7-TETRAHYDTOXYFLAVONE

ROBIGENIN

3,4'

Kaempferol,3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Robigenin

KAEMPFEROL(RG)(PLEASECALL)

3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chroMen-4-one

KaeMpferol&nbsp

4β-Hydroxy Cholesterol-d4 (Major)

NSC 407289

NSC 656277

Pelargidenon

Trifolitin

4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-

Kaempferol ,98%

Kaempferol, 98%, from Sophora japonica Linn.

Nano Liposomal Kaempferol

Kaempferol - CAS 520-18-3 - Calbiochem

Kaempferol 520-18-3

KAEMPFEROL(AMERICAN HERBAL PHARMACOPOEIA)

3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one

KAEMPFERIDE(SH)

Kaempferol 97 % pure

KAEMPFEROL FROM GINKGO BILOBA LEAF 99+%(HPLC)

KAEMPFEROL 98%

KAEMPFEROL ROBIGENIN, 3,4',5,7-TETRAHYDRO-XY-FLAVONE

Rhamnoluteun

Robigenin/Kaempferol

asurone

KAEMPFEROL hplc

3,4',5,7-Tetrahydroxyflavone

KAEMPFEROL ROBIGENIN

KAEMPFEROL WITH HPLC

3,4μ,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Robigenin

4',5,7-Trihydroxyflavonol

Swartsiol

3.5,7,4'-tetrahydroxyflavone Swartziol Trifolitin Nimbecetin Populnetin

Kaempferol Hydrate

KaempferolHydrate&gt

Kaempferol (3,4',5,7-Tetrahydroxyflavone)